Targeting neuronal dysfunction and receptor imaging

Camacho, Valle; Carrió, Ignasi

doi:10.1016/j.copbio.2007.01.002

Cited by 14 publications

(9 citation statements)

References 25 publications

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“…A washout rate is calculated by determining change in H:M ratios between images acquired early and late. A late H:M ratio of greater than 1.8 and a washout rate of less than 10% have been considered normal [2]. However, variability exists in these values depending on the analysis method used, with some studies demonstrating higher H:M values [3].…”

Section: Imaging Cardiac Sympathetic Functionmentioning

confidence: 98%

Evaluating presynaptic and postsynaptic innervation in heart failure

Chen¹,

Caldwell

2009

Curr Cardiol Rep

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Congestive heart failure increasingly contributes to the overall morbidity and mortality associated with cardiovascular disease. Although significant advances in therapies allow patients to feel better and have improved functional status and survival, not all patients respond equally to these therapies. Moreover, for any given level of left ventricular systolic dysfunction, it is difficult to predict who will have progressive heart failure leading to death or transplantation or who will die suddenly. It has long been recognized that the sympathetic nervous system plays a major role in the morbidity and mortality associated with congestive heart failure from systolic left ventricular dysfunction. Although some of the sympathetic effect occurs at the systemic level, malfunction at the ventricular myocyte-sympathetic nerve terminal interface is likely a major contributor to sudden death and progressive heart failure. Imaging the cardiac sympathetic nervous system can be used to evaluate this myoneural interface and to predict outcome.

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Section: Imaging Cardiac Sympathetic Functionmentioning

confidence: 98%

Evaluating presynaptic and postsynaptic innervation in heart failure

Chen¹,

Caldwell

2009

Curr Cardiol Rep

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“…At present, the most commonly used SPECT tracer to assess cardiac neurotransmission is 123 I-MIBG [8]. It is widely accepted as a good method for assessing myocardial sympathetic nerve activity and innervation in a variety of cardiac disease states and the effect of treatment with cardiovascular drugs in chronic heart failure [9].…”

Section: I-mibgmentioning

confidence: 99%

“…MIBG (metaiodobenzylguanidine) is an analogue of the "false" neurotransmitter guanetidine, a potent neuronblocking agent that acts selectively on sympathetic nerves. MIBG has a molecular structure similar to that of noradrenaline and shares the same uptake and storage mechanisms in the sympathetic nerve endings [8].…”

Section: I-mibgmentioning

confidence: 99%

Nuclear imaging in cardiac amyloidosis

Glaudemans

Slart

Zeebregts

et al. 2009

Eur J Nucl Med Mol Imaging

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Amyloidosis is a disease characterized by depositions of amyloid in organs and tissues. It can be localized (in just one organ) or systemic. Cardiac amyloidosis is a debilitating disease and can lead to arrhythmias, deterioration of heart function and even sudden death. We reviewed PubMed/Medline, without time constraints, on the different nuclear imaging modalities that are used to visualize myocardial amyloid involvement. Several SPECT tracers have been used for this purpose. The results with these tracers in the evaluation of myocardial amyloidosis and their mechanisms of action are described. Most clinical evidence was found for the use of 123 I-MIBG. Myocardial defects in MIBG activity seem to correlate well with impaired cardiac sympathetic nerve endings due to amyloid deposits. 123 I-MIBG is an attractive option for objective evaluation of cardiac sympathetic level and may play an important role in the indirect measurement of the effect of amyloid myocardial infiltration. Other, less sensitive, options are 99m Tc-aprotinin for imaging amyloid deposits and perhaps 99m Tc-labelled phosphate derivatives, especially in the differential diagnosis of the aetiology of cardiac amyloidosis. PET tracers, despite the advantage of absolute quantification and higher resolution, are not yet well evaluated for the study of cardiac amyloidosis. Because of these advantages, there is still the need for further research in this field.

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“…LBD are associated with imaging evidence of substantial myocardial sympathetic denervation by iodine-123-metaiodobenzylguanidine ([ 123 I]-MIBG) scintigraphy (Treglia et al 2010 ) and by carbon-11-metahydroxyephedrine ([ 11 C]-mHED) and fl uorine-18-fl uorodopamine ([ 18 F]-dopamine) positron emission tomography (PET) (Bengel and Schwaiger 2004 (Yamashina and Yamazaki 2007 ;Camacho and Carrio 2007 ;Treglia et al 2010 ).…”

Section: Introductionmentioning

confidence: 99%