Targeting N-doped graphene quantum dot with high photothermal conversion efficiency for dual-mode imaging and therapy <i>in vitro</i>

Ye, Xuan; Zhang, Ruo‐Yun; Zhang, Xiaoshuai; An, Jie; Cheng, Kai; Li, Cheng; Hou, Xiaolin; Zhao, Yuan‐Di

doi:10.1088/1361-6528/aacad0

Cited by 49 publications

(27 citation statements)

References 33 publications

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“…In recent years, the applications of GQDs in drug delivery [123][124][125][126][127], sensors [128][129][130][131][132][133][134], bio-imaging [10,63,[135][136][137][138][139][140], magnetic hyperthermia [141][142][143], photothermal therapy [144][145][146][147][148], antibacterial [145,149,150], catalyst [69,[151][152][153][154][155], environmental protection [38,156,157], and energy [158][159][160][161][162][163] has made remarkable accomplishment. In order to better apply GQDs to drug delivery, some researchers had used density functional theory (DFT) calculations [164]…”

Section: Applications Of Gqds In Drug Deliverymentioning

confidence: 99%

Synthesis of graphene quantum dots and their applications in drug delivery

et al. 2020

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This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.

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Section: Applications Of Gqds In Drug Deliverymentioning

confidence: 99%

Synthesis of graphene quantum dots and their applications in drug delivery

et al. 2020

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“…Nevertheless, in vivo applications of all carbon NPs are still in infancy. Very recently, other all carbon NPs [133] have been synthetized, like N-doped graphene (N-G) CNDs, with the advantages of low cost, low cytotoxicity, and higher photothermal conversion efficiency than other C-based nanomaterials currently available. In addition, N-G-CNDs conjugated with FA have enabled for active targeting of several tumor cell types in vitro, aiming future preclinical employ for in vivo dual-mode FL-PA imaging and PTT.…”

Section: Biomedical Pai Applications Based On Exogenous Optical Comentioning

confidence: 99%

State-of-the-Art Preclinical Photoacoustic Imaging in Oncology: Recent Advances in Cancer Theranostics

Gargiulo

Albanese

Mancini

2019

Contrast Media & Molecular Imaging

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The optical imaging plays an increasing role in preclinical studies, particularly in cancer biology. The combined ultrasound and optical imaging, named photoacoustic imaging (PAI), is an emerging hybrid technique for real-time molecular imaging in preclinical research and recently expanding into clinical setting. PAI can be performed using endogenous contrast, particularly from oxygenated and deoxygenated hemoglobin and melanin, or exogenous contrast agents, sometimes targeted for specific biomarkers, providing comprehensive morphofunctional and molecular information on tumor microenvironment. Overall, PAI has revealed notable opportunities to improve knowledge on tumor pathophysiology and on the biological mechanisms underlying therapy. The aim of this review is to introduce the principles of PAI and to provide a brief overview of current PAI applications in preclinical research, highlighting also on recent advances in clinical translation for cancer diagnosis, staging, and therapy.

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“…However, the toxicity studies on N-GQDs are underway and have not yet reached a consistent conclusion. Even though some researchers have suggested N-GQDs have low cytotoxicity [ 8 ], others show N-GQDs could be internalized into cells and disrupt some enzyme activities [ 9 ]. The N-GQDs, as fluorescent nanoprobes, could contribute to the development of nanotheranostics in the field of neuronscience due to their excellent optical properties, so it is significant to evaluate the interaction between N-GQDs and neurobiological models before applying them in living organisms.…”

Section: Introductionmentioning

confidence: 99%

Induction of ferroptosis in response to graphene quantum dots through mitochondrial oxidative stress in microglia

Liu

et al. 2020

Part Fibre Toxicol

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Background Graphene quantum dots (GQDs) provide a bright prospect in the biomedical application because they contain low-toxic compounds and promise imaging of deep tissues and tiny vascular structures. However, the biosafety of this novel QDs has not been thoroughly evaluated, especially in the central nervous system (CNS). The microarray analysis provides a hint that nitrogen-doped GQDs (N-GQDs) exposure could cause ferroptosis in microglia, which is a novel form of cell death dependent on iron overload and lipid peroxidation. Results The cytosolic iron overload, glutathione (GSH) depletion, excessive reactive oxygen species (ROS) production and lipid peroxidation (LPO) were observed in microglial BV2 cells treated with N-GQDs, which indicated that N-GQDs could damage the iron metabolism and redox balance in microglia. The pre-treatments of a specific ferroptosis inhibitor Ferrostatin-1 (Fer-1) and an iron chelater Deferoxamine mesylate (DFO) not only inhibited cell death, but also alleviated iron overload, LPO and alternations in ferroptosis biomarkers in microglia, which were caused by N-GQDs. When assessing the potential mechanisms of N-GQDs causing ferroptosis in microglia, we found that the iron content, ROS generation and LPO level in mitochondria of BV2 cells all enhanced after N-GQDs exposure. When the antioxidant ability of mitochondria was increased by the pre-treatment of a mitochondria targeted ROS scavenger MitoTEMPO, the ferroptotic biological changes were effectively reversed in BV2 cells treated with N-GQDs, which indicated that the N-GQDs-induced ferroptosis in microglia could be attributed to the mitochondrial oxidative stress. Additionally, amino functionalized GQDs (A-GQDs) elicited milder redox imbalance in mitochondria and resulted in less ferroptotic effects than N-GQDs in microglia, which suggested a slight protection of amino group functionalization in GQDs causing ferroptosis. Conclusion N-GQDs exposure caused ferroptosis in microglia via inducing mitochondrial oxidative stress, and the ferroptotic effects induced by A-GQDs were milder than N-GQDs when the exposure method is same. This study will not only provide new insights in the GQDs-induced cell damage performed in multiple types of cell death, but also in the influence of chemical modification on the toxicity of GQDs.

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Targeting N-doped graphene quantum dot with high photothermal conversion efficiency for dual-mode imaging and therapy in vitro

Cited by 49 publications

References 33 publications

Synthesis of graphene quantum dots and their applications in drug delivery

Synthesis of graphene quantum dots and their applications in drug delivery

State-of-the-Art Preclinical Photoacoustic Imaging in Oncology: Recent Advances in Cancer Theranostics

Induction of ferroptosis in response to graphene quantum dots through mitochondrial oxidative stress in microglia

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