Targeting mTORs by omega-3 fatty acids: A possible novel therapeutic strategy for neurodegeneration?

Shirooie, Samira; Nabavi, Seyed Fazel; Dehpour, Ahmad Reza; Belwal, Tarun; Habtemariam, Solomon; Argüelles, Sandro; Sureda, Antoni; Daglia, Maria; Sobarzo‐Sánchez, Eduardo; Xu, Suowen; Nabavi, Seyed Mohammad

doi:10.1016/j.phrs.2018.07.004

Cited by 27 publications

(17 citation statements)

References 236 publications

(227 reference statements)

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“…Moreover, based on its cytostatic activity, rapamycin could be used as an anti-cancer agent. More recently, rapamycin has also shown to contribute to the prevention of coronary artery restenosis [200] as well as to the treatment of neurodegenerative diseases [201]. New inhibitors of mTOR are being designed.…”

Section: Pharmacological Use Of Different Mtor Inhibitor Familiesmentioning

confidence: 99%

mTOR: A Cellular Regulator Interface in Health and Disease

Boutouja

Stiehm

Platta

2019

Cells

115

110

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The mechanistic target of Rapamycin (mTOR) is a ubiquitously-conserved serine/threonine kinase, which has a central function in integrating growth signals and orchestrating their physiologic effects on cellular level. mTOR is the core component of differently composed signaling complexes that differ in protein composition and molecular targets. Newly identified classes of mTOR inhibitors are being developed to block autoimmune diseases and transplant rejections but also to treat obesity, diabetes, and different types of cancer. Therefore, the selective and context-dependent inhibition of mTOR activity itself might come into the focus as molecular target to prevent severe diseases and possibly to extend life span. This review provides a general introduction to the molecular composition and physiologic function of mTOR complexes as part of the Special Issue “2018 Select Papers by Cells’ Editorial Board Members”.

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Section: Pharmacological Use Of Different Mtor Inhibitor Familiesmentioning

confidence: 99%

mTOR: A Cellular Regulator Interface in Health and Disease

Boutouja

Stiehm

Platta

2019

Cells

115

110

View full text Add to dashboard Cite

show abstract

“…Although, to date, no link was established between n -3-PUFA, mTOR, and ADHD some evidence has been reported for n -3-PUFA and mTOR in other neuropsychiatric disorders. Based on mounting evidence proving that n- 3-PUFA have beneficial effects on people affected by depression, schizophrenia, and bipolar disorder 115 – 117 in combination with data on the correlation between mTOR and other pathologies (e.g., cancer), Shirooie and colleagues 118 reviewed that mTOR can be one of n -3-PUFA’s targets to treat neurodegenerative diseases by regulating essential cellular processes such as apoptosis and autophagy. In addition, Giacobbe and colleagues 119 have recently discussed the anti-inflammatory effect of n -3-PUFA within the context of neuropsychiatric disorders such as depression.…”

Section: Introductionmentioning

confidence: 99%

The stress–Wnt-signaling axis: a hypothesis for attention-deficit hyperactivity disorder and therapy approaches

et al. 2020

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Attention-deficit hyperactivity disorder (ADHD) is one of the most common psychiatric neurodevelopmental disorders in children and adolescents. Although ADHD has been studied for nearly a century, the cause and pathophysiology of ADHD is yet largely unknown. However, findings from previous studies have resulted in the formation of a new hypothesis: Apart from the well-known multifactorial etiology of ADHD, recent evidence suggests that the interaction between genetic and environmental factors and especially Wnt- and mTOR-signaling pathways might have an important role in the pathophysiology of ADHD. The Wnt-signaling pathway is known to orchestrate cellular proliferation, polarity, and differentiation, and the mTOR pathway is involved in several significant processes of neurodevelopment and synaptic plasticity. As a result, dysregulations of these pathways in a time-dependent manner could lead to neurodevelopmental delays, resulting in ADHD phenotype. This review presents further evidence supporting our hypothesis by combining results from studies on ADHD and Wnt- or mTOR-signaling and the influence of genetics, methylphenidate treatment, Omega-3 supplementation, and stress.

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“…Moreover, these PUFAs also exert significant protective effects against inflammatory damage to the neurons and glial cells. Omega-3 fatty acids have also been reported to show promising effects as antidepressant agents [63].…”

Section: Neuroprotective Phytochemicals In Pistacia Genusmentioning

confidence: 99%

Pistacia Genus as a Potential Source of Neuroprotective Natural Products

et al. 2019

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Neuroprotective agents are able to defend the central nervous system against acute or chronic neuronal injuries. Even with the progress made over the last decades, most of the medications prescribed for the management of neurodegenerative diseases can only reduce their symptoms and slow down their progression. Based on natural product research, there are potential effective medicinal plants and phytochemicals for modulating neuronal functions and protecting against neurodegeneration. Plants in the genus Pistacia are also among valuable natural resources for neuroprotection research based on experiences in traditional medicine. Studies have supported the value of bioactive compounds of the genus Pistacia for central nervous system disorders such as Alzheimerʼs, Parkinsonʼs, multiple sclerosis, cerebral ischemia, depression, and anxiety. Related literature has also revealed that most of the evidence on neuroprotection in the genus Pistacia is in the form of preliminary studies, mainly including models of behavior, motor function, and memory impairments in animals, neural toxicity, cerebral ischemia and seizure models, evaluation of their effects on antioxidant and inflammatory biomarkers, amyloid β aggregation, and acetylcholinesterase as well as investigations into some cellular pathways. Along with the phytonutrients in kernels such as pistachios, various phytochemicals, mostly terpenes, and phenolic compounds have also been identified in different plant parts, in particular their oleoresins, of species in the genus Pistacia. In this review, the pharmacology of neurological effects and related molecular mechanisms of the plants belonging to the genus Pistacia and its active constituents, as well as pharmacokinetics aspects, are discussed.

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Targeting mTORs by omega-3 fatty acids: A possible novel therapeutic strategy for neurodegeneration?

Cited by 27 publications

References 236 publications

mTOR: A Cellular Regulator Interface in Health and Disease

mTOR: A Cellular Regulator Interface in Health and Disease

The stress–Wnt-signaling axis: a hypothesis for attention-deficit hyperactivity disorder and therapy approaches

Pistacia Genus as a Potential Source of Neuroprotective Natural Products

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