Targeting MTHFR for the treatment of migraines

Rainero, Innocenzo; Vacca, Alessandro; Roveta, Fausto; Govone, Flora; Gai, Annalisa; Rubino, Elisa

doi:10.1080/14728222.2019.1549544

Cited by 23 publications

(19 citation statements)

References 95 publications

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“…Liu et al concluded that the 677T allele was associated with an increased risk of total migraine and MA in Asians [97]. Similar results were obtained in other analyses with the general conclusions supporting the use of folate in migraine patients, especially those with auras, but further replication studies are needed, particularly large randomized clinical trials [96].…”

Section: Folate and Its Role In Dna Methylation And Migraine Pathomentioning

confidence: 55%

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Is an “Epigenetic Diet” for Migraines Justified? The Case of Folate and DNA Methylation

Fila

Chojnacki

et al. 2019

Nutrients

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Migraines are a common disease with limited treatment options and some dietary factors are recognized to trigger headaches. Although migraine pathogenesis is not completely known, aberrant DNA methylation has been reported to be associated with its occurrence. Folate, an essential micronutrient involved in one-carbon metabolism and DNA methylation, was shown to have beneficial effects on migraines. Moreover, the variability of the methylenetetrahydrofolate reductase gene, important in both folate metabolism and migraine pathogenesis, modulates the beneficial effects of folate for migraines. Therefore, migraine could be targeted by a folate-rich, DNA methylation-directed diet, but there are no data showing that beneficial effects of folate consumption result from its epigenetic action. Furthermore, contrary to epigenetic drugs, epigenetic diets contain many compounds, some yet unidentified, with poorly known or completely unknown potential to interfere with the epigenetic action of the main dietary components. The application of epigenetic diets for migraines and other diseases requires its personalization to the epigenetic profile of a patient, which is largely unknown. Results obtained so far do not warrant the recommendation of any epigenetic diet as effective in migraine prevention and therapy. Further studies including a folate-rich diet fortified with valproic acid, another modifier of epigenetic profile effective in migraine prophylaxis, may help to clarify this issue.

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Section: Folate and Its Role In Dna Methylation And Migraine Pathomentioning

confidence: 55%

“…The 677C > T polymorphism of the MTHFR gene is likely the most frequently addressed genetic aspect of migraine pathophysiology, but the results obtained so far are not conclusive [96]. This polymorphism is claimed to be both an independent and combined marker for migraines, especially MA.…”

Section: Folate and Its Role In Dna Methylation And Migraine Pathomentioning

confidence: 99%

Is an “Epigenetic Diet” for Migraines Justified? The Case of Folate and DNA Methylation

Fila

Chojnacki

et al. 2019

Nutrients

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“…Thus, the supplementation of these factors results in lowering Hcy levels 19 . In this context, interventions targeting Hcy metabolism, mainly Hcy‐lowering vitamins, might exert a beneficial effect on patients with migraine 20 …”

Section: Introductionmentioning

confidence: 99%

“…19 In this context, interventions targeting Hcy metabolism, mainly Hcy-lowering vitamins, might exert a beneficial effect on patients with migraine. 20 Dietary interventions have already accumulated significant interest in the prevention of migraine and headache. 21,22 Menon et al 2015 have investigated dietary folate intake and have demonstrated its inverse relationship with migraine frequency.…”

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confidence: 99%

Pyridoxine, folate and cobalamin for migraine: A systematic review

et al. 2020

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Migraine is a common primary headache disorder prevalent among middle-aged adults, with its prevalence peaking in adults during the fourth decade of life and registering its lowest values in adolescents and adults older than 60 years of age. 1 It is often characterized by severe-debilitating headaches that significantly impair everyday functioning and productivity, constituting a major psychological and financial burden for people and society. 2,3 The cardinal pain features of migraine, usually, involve unilateral distribution, throbbing quality, moderate to severe intensity and exacerbation with physical activity. 4,5 Nausea and

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“…In the case of migraine, the evidence is somewhat more circumspect 76,77 ; however, targeting methylenetetrahydrofolate reductase is regarded as a potential therapeutic option. 78 The evidence of the link between an NNMT SNP and homocysteine levels stems primarily from the work of Souto et al 79 These authors examined plasma homocysteine concentration and DNA from 398 subjects from 21 extended Spanish families. They conducted a genome-wide analysis covering all 22 autosomes using 363 DNA markers and related homocysteine concentration to individual the DNA markers.…”

Section: Nnmt -Association With Homocysteine Metabolism and Illnessmentioning

confidence: 99%

NicotinamideN-Methyltransferase: Genomic Connection to Disease

Ramsden

Waring

Parsons

et al. 2020

Int J�Tryptophan�Res

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Single-nucleotide polymorphisms (SNPs) in and around the nicotinamide N-methyltransferase (NNMT) gene are associated with a range of cancers and other diseases and conditions. The data on these associations have been assembled, and their strength discussed. There is no evidence that the presence of either the major or minor base in any SNP affects the expression of nicotinamide N-methyltransferase. Nevertheless, suggestions have been put forward that some of these SNPs do affect NNMT expression and thus homocysteine metabolism. An alternative idea involving non-coding messenger RNAs (mRNAs) is suggested as a possible mechanism whereby health is influenced. It is postulated that these long, non-coding NNMT mRNAs may exert deleterious effects by interfering with the expression of other genes. Neither hypothesis, however, has experimental proof, and further work is necessary to elucidate NNMT genetic interactions.

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Targeting MTHFR for the treatment of migraines

Cited by 23 publications

References 95 publications

Is an “Epigenetic Diet” for Migraines Justified? The Case of Folate and DNA Methylation

Is an “Epigenetic Diet” for Migraines Justified? The Case of Folate and DNA Methylation

Pyridoxine, folate and cobalamin for migraine: A systematic review

NicotinamideN-Methyltransferase: Genomic Connection to Disease

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