Targeting monocyte and macrophage subpopulations for immunotherapy: a patent review (2009 – 2013)

Jackson, William D.; Woollard, Kevin J.

doi:10.1517/13543776.2014.914495

Cited by 9 publications

(6 citation statements)

References 89 publications

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“…Recruitment of monocytes, the precursors of mature inflammatory macrophages, into affected joints is essential for an initiation and progression of joint inflammation. Therefore, several methods have been established to remove circulating monocytes or prevent the recruitment of monocytes into joints, including use of immune-modifying microparticles (polystyrene, micro-diamonds, or biodegradable poly-microparticles), either in experimental or therapeutic applications ( 70 , 71 ). As expected, arthritis was suppressed in mouse models.…”

Section: Other Mls- or Fls-associated Potential Ra Therapiesmentioning

confidence: 99%

Ontology and Function of Fibroblast-Like and Macrophage-Like Synoviocytes: How Do They Talk to Each Other and Can They Be Targeted for Rheumatoid Arthritis Therapy?

Hong

Zhang

et al. 2018

Front. Immunol.

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Fibroblast-like synoviocytes (FLS) and macrophage-like synoviocytes (MLS) are the two main cellular components of the synovium. It has been widely reported that FLS and MLS play essential roles in the joint pathology of rheumatoid arthritis (RA). Although various studies have analyzed both human and animal tissues and have shown that both cell types are involved in different stages of RA, ontology, and specific functions of both cell populations and their interactions are not well understood. In this review, we will summarize recent research on FLS and MLS in RA and focus on the development and function of two predominant synovial cell types. In addition, we will discuss the communication between FLS or MLS and highlight potential treatments for RA that involve synoviocytes.

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Section: Other Mls- or Fls-associated Potential Ra Therapiesmentioning

confidence: 99%

Ontology and Function of Fibroblast-Like and Macrophage-Like Synoviocytes: How Do They Talk to Each Other and Can They Be Targeted for Rheumatoid Arthritis Therapy?

Hong

Zhang

et al. 2018

Front. Immunol.

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“…Stimulation of the innate immune system to overcome microbe-specific mechanisms of evasion represents a broad-spectrum approach to protect animals from disease. Most efforts in this area focus on cells of the myeloid lineage, such as macrophages and neutrophils (Jackson and Woollard, 2014). However, other non-myeloid cells, such as certain innate-like lymphocyte subsets are also important in innate immunity.…”

Section: Introductionmentioning

confidence: 99%

Adjuvant materials that enhance bovine γδ T cell responses

Hedges

Holderness

Jutila

2016

Veterinary Immunology and Immunopathology

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Despite the availability of vaccines and antibiotics, viral, bacterial and parasite-induced intestinal and pulmonary diseases still cause significant losses to the livestock industry. Excepting improvements in calf survival due to predation, there have been only modest improvements in bovine calf survival since 1991. Strikingly, digestive and respiratory diseases still account for almost half of the non-predator deaths in calves. The innate immune system has evolved to rapidly recognize and respond to invasive microbial threats. Augmentation of innate immunity is a broad-spectrum, potent and non-specific alternative approach to effectively counter a microbial invasion. In recent years we have focused our research efforts on the development of effective and inexpensive adjuvant therapies for cattle that can be used to help mitigate infection. Unique in our approach to the development of the potential new treatments, is our focus on bovine γδ T cells, which are important lymphocytes of the innate immune system and of particular importance to ruminant immunological health. This review focuses on recent results obtained using two such adjuvant materials.

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“…Thus, monocytes are described as classical (CD14 ++ /CD16 -), intermediate (CD14 ++ /CD16 + ), or non-classical (CD14 dim /CD16 + ) [21].The distinctions between these groups are not completely defined, and they may represent a maturation continuum rather than clear-cut divisions [22]. Nevertheless, these sub-divisions are backed-up by differences in phenotype, in cytokine production at homeostasis or in response to infections, in phagocytosis capability, in the internalization and presentation of antigens, in the ability to differentiate, and in trafficking and migration [23,24].…”

Section: Monocytes In Inflammation and Autoimmune Diseasesmentioning

confidence: 99%

“…However, significant depletion of the monocyte pool would severely affect innate immunity with a corresponding increase in susceptibility to sepsis. Targeting of specific monocyte subsets has been proposed, but a clear pathogenic subgroup has not yet been delineated in AAV, and our understanding of the plasticity and consequent dynamic phenotype of monocytes is still in its infancy [24]. A fascinating therapeutic development in this direction could consist of "reprogramming" monocytes, possibly via epigenetic mechanisms.…”

Section: Would Therapeutic Targeting Of Monocytes Be Beneficial In Aav?mentioning

confidence: 99%

The role of monocytes in ANCA-associated vasculitides

Brunini

Page

Gallieni

et al. 2016

Autoimmunity Reviews

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The anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) are a heterogeneous group of diseases causing inflammation in small blood vessels and linked by the presence of circulating ANCA specific for proteinase 3 (PR3) or myeloperoxidase (MPO). These antigens are present both in the cytoplasmic granules and on the surface of neutrophils, and the effect of ANCA on neutrophil biology has been extensively studied. In contrast, less attention has been paid to the role of monocytes in AAV. These cells contain PR3 and MPO in lysosomes and can also express them at the cell surface. Monocytes respond to ANCA by producing pro-inflammatory and chemotactic cytokines, reactive-oxygen-species and by up-regulating CD14. Moreover, soluble and cell surface markers of monocyte activation are raised in AAV patients, suggesting an activated phenotype that may persist even during disease remission. The presence of monocyte-derived macrophages and giant cells within damaged renal and vascular tissue in AAV also attests to their role in pathogenesis. In particular, their presence in the tertiary lymphoid organ-like granulomas of AAV patients may generate an environment predisposed to maintaining autoimmunity. Here we discuss the evidence for a pathogenic role of monocytes in AAV, their role in granuloma formation and tissue damage, and their potential to both direct and maintain autoimmunity. ANCA-activation of monocytes may therefore provide an explanation for the relapsing-remitting course of disease and its links with infections. Monocytes may thus represent a promising target for the treatment of this group of life-threatening diseases.

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Targeting monocyte and macrophage subpopulations for immunotherapy: a patent review (2009 – 2013)

Cited by 9 publications

References 89 publications

Ontology and Function of Fibroblast-Like and Macrophage-Like Synoviocytes: How Do They Talk to Each Other and Can They Be Targeted for Rheumatoid Arthritis Therapy?

Ontology and Function of Fibroblast-Like and Macrophage-Like Synoviocytes: How Do They Talk to Each Other and Can They Be Targeted for Rheumatoid Arthritis Therapy?

Adjuvant materials that enhance bovine γδ T cell responses

The role of monocytes in ANCA-associated vasculitides

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