2023
DOI: 10.1113/jp284143
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Targeting mitochondrial Ca2+ uptake for the treatment of amyotrophic lateral sclerosis

Renjia Zhong,
Michael T. Rua,
Lan Wei‐LaPierre

Abstract: Amyotrophic lateral sclerosis (ALS) is a rare adult‐onset neurodegenerative disease characterized by progressive motor neuron (MN) loss, muscle denervation and paralysis. Over the past several decades, researchers have made tremendous efforts to understand the pathogenic mechanisms underpinning ALS, with much yet to be resolved. ALS is described as a non‐cell autonomous condition with pathology detected in both MNs and non‐neuronal cells, such as glial cells and skeletal muscle. Studies in ALS patient and anim… Show more

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