Targeting miRNAs by polyphenols: Novel therapeutic strategy for cancer

Devi, Kasi Pandima; Rajavel, Tamilselvam; Daglia, Maria; Nabavi, Seyed Fazel; Bishayee, Anupam

doi:10.1016/j.semcancer.2017.02.001

Cited by 71 publications

(34 citation statements)

References 141 publications

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“…miRNAs post‐transcriptionally regulate gene expression by promoting the degradation of target mRNAs or by inhibiting the translation of target mRNAs. Aberrant expression of miRNAs is involved in the development of human cancers . It has been reported that miR‐206 is dysregulated and linked to several types of cancers .…”

Section: Discussionmentioning

confidence: 99%

miR‐206 inhibits the growth of hepatocellular carcinoma cells via targeting CDK9

et al. 2017

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AbstractmiR‐206 plays an important role in regulating the growth of multiple cancer cells. Cyclin‐dependent kinase 9 (CDK9) stimulates the production of abundant prosurvival proteins, leading to impaired apoptosis of cancer cells. However, it is unknown whether CDK9 is involved in the miR‐206‐mediated growth suppression of hepatocellular carcinoma (HCC) cells. In this study, we found that the expression level of miR‐206 was significantly lower in HCC cell lines than that in normal hepatic cell line (L02). Meanwhile, CDK9 was upregulated in HCC cell lines. Moreover, miR‐206 downregulated CDK9 in HCC cells via directly binding to its mRNA 3′ UTR, which resulted in a decrease of RNA PolII Ser2 phosphorylation and Mcl‐1 level. Additionally, miR‐206 suppressed the cell proliferation, and induced cell cycle arrest and apoptosis. Similarly, silence or inhibition of CDK9 also repressed the cell proliferation, and induced cell cycle arrest and apoptosis. Taken together, the results demonstrated that miR‐206 inhibited the growth of HCC cells through targeting CDK9, suggesting that the miR‐206‐CDK9 pathway may be a novel target for the treatment of HCC.

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Section: Discussionmentioning

confidence: 99%

miR‐206 inhibits the growth of hepatocellular carcinoma cells via targeting CDK9

et al. 2017

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“…MicroRNAs (miRNA) are a specific type of single stranded RNA sequences that do not code for proteins. These sequences are usually short in length, consisting of only a few nucleotides (typically 19–25) and they negatively regulate their targets [ 180 , 181 ]. miRNA act at the mRNA level, where they complementary interact with their target mRNA.…”

Section: Future Directionsmentioning

confidence: 99%

Polyphenolic Nutrients in Cancer Chemoprevention and Metastasis: Role of the Epithelial-to-Mesenchymal (EMT) Pathway

et al. 2017

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The epithelial-to-mesenchymal transition (EMT) has received significant interest as a novel target in cancer prevention, metastasis, and resistance. The conversion of cells from an epithelial, adhesive state to a mesenchymal, motile state is one of the key events in the development of cancer metastasis. Polyphenols have been reported to be efficacious in the prevention of cancer and reversing cancer progression. Recently, the antimetastatic efficacy of polyphenols has been reported, thereby expanding the potential use of these compounds beyond chemoprevention. Polyphenols may affect EMT pathways, which are involved in cancer metastasis; for example, polyphenols increase the levels of epithelial markers, but downregulate the mesenchymal markers. Polyphenols also alter the level of expression and functionality of important proteins in other signaling pathways that control cellular mesenchymal characteristics. However, the specific proteins that are directly affected by polyphenols in these signaling pathways remain to be elucidated. The aim of this review is to analyze current evidence regarding the role of polyphenols in attenuating EMT-mediated cancer progression and metastasis. We also discuss the role of the most important polyphenol subclasses and members of the polyphenols in reversing metastasis and targeting EMT. Finally, limitations and future directions to improve our understanding in this field are discussed.

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“…However, this therapeutic strategy is associated with important limitations such as chemo‐resistance. Multiple lines of evidence have indicated that some cellular and molecular targets such as p53, Akt, COX‐2,STAT3, MAPK, and miRNAs could be involved in chemo‐resistance or chemo‐sensitivity (Pandima Devi et al, ). However, precise cellular and molecular pathways involved in resistance to cancer‐associated therapies remain unknown (Zhou et al, ).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA: A novel target of curcumin in cancer therapy

Mirzaei

Masoudifar

Sahebkar

et al. 2017

Journal Cellular Physiology

210

173

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Curcumin is known as a natural dietary polyphenol which is extracted from Curcuma longa L. It has been shown that curcumin has a variety of pharmacological effects such as antioxidant, anti-cancer, anti-inflammatory, and anti-microbial activities. Anti-cancer effects of curcumin are due to targeting of a wide range of cellular and molecular pathways involved in cancer pathogenesis including NF-kB, MAPK, PTEN, P53, and microRNAs (miRNA) network. Multiple lines of evidence have indicated that curcumin exerts its therapeutic effects via regulating miRNA expression (e.g., miR-1, miR-7, miR-9, miR-34a, miR-181, miR-21, and miR-19) which could lead to the regulation of underlying cellular and molecular pathways involved in cancer pathogenesis. Exosomes are one of the important classes of biological vehicles which could be released from various types of cells such as cancer cells and stem cells and could change the behavior of recipient cells. It has been shown that treatment of cancer cells with different dose of curcumin leads to the release of exosomes containing curcumin. These exosomes could induce anti-cancer properties in recipient cells and reduce tumor growth. Hence, exosomes containing curcumin could be applied as powerful tools for cancer treatment. Here, we highlighted various miRNAs which could be affected by curcumin in various types of cancer. Moreover, we highlight exosomes containing curcumin as suitable therapeutic tools in cancer therapy.

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Targeting miRNAs by polyphenols: Novel therapeutic strategy for cancer

Cited by 71 publications

References 141 publications

miR‐206 inhibits the growth of hepatocellular carcinoma cells via targeting CDK9

miR‐206 inhibits the growth of hepatocellular carcinoma cells via targeting CDK9

Polyphenolic Nutrients in Cancer Chemoprevention and Metastasis: Role of the Epithelial-to-Mesenchymal (EMT) Pathway

MicroRNA: A novel target of curcumin in cancer therapy

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