Targeting miRNA by Natural Products: A Novel Therapeutic Approach for Nonalcoholic Fatty Liver

Zobeiri, Mehdi; Parvizi, Fatemeh; Kalhori, Mohammad Reza; Majnooni, Mohammad Bagher; Farzaei, Mohammad Hosein; Abdollahi, Mohammad

doi:10.1155/2021/6641031

Cited by 13 publications

(18 citation statements)

References 158 publications

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“…Thus, a possible mechanism is that the increased lipid sequestration in lipid droplets results in insufficient membrane permeability to allow virion formation, resulting in decreased virus production, and increased cellular E protein, as observed in this study. However, berberine has been shown to act through a number of other mechanisms including acting as an antioxidant and anti-inflammatory [57], as a repressor of DNA repair and replication [58], modulating noncoding RNAs, including miRNAs [59] and modulating autophagy [60], all of which could possibly impact how berberine affects viral replication, or its effects in other disease processes.…”

Section: Discussionmentioning

confidence: 99%

Berberine Inhibits Dengue Virus through Dual Mechanisms

et al. 2021

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Mosquito transmitted viruses, particularly those of the genus Flavivirus, are a significant healthcare burden worldwide, especially in tropical and sub-tropical areas. However, effective medicines for these viral infections remains lacking. Berberine (BBR) is an alkaloid found in some plants used in traditional medicines in Southeast Asia and elsewhere, and BBR has been shown to possess anti-viral activities. During a screen for potential application to mosquito transmitted viruses, BBR was shown to have virucidal activity against dengue virus (DENV; IC50 42.87 µM) as well as against Zika virus (IC50 11.42 µM) and chikungunya virus (IC50 14.21 µM). BBR was shown to have cellular effects that lead to an increase in cellular DENV E protein without a concomitant effect on DENV nonstructural proteins, suggesting an effect on viral particle formation or egress. While BBR was shown to have an effect of ERK1/2 activation this did not result in defects in viral egress mechanisms. The primary effect of BBR on viral production was likely to be through BBR acting through AMPK activation and disruption of lipid metabolism. Combined these results suggest that BBR has a dual effect on DENV infection, and BBR may have the potential for development as an anti-DENV antiviral.

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Section: Discussionmentioning

confidence: 99%

Berberine Inhibits Dengue Virus through Dual Mechanisms

et al. 2021

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“…As a result, differentiation-promoting drugs may be able to delay the growth of GBM and medulloblastoma in patients, diminish cancer resistance, and avoid recurrence [ 99 ], as evidenced by decreased nesting (a stem cell marker) and increased expression of the glial acidic fibrillary protein (a mature glial cell marker) and beta III-tubulin (a neuronal differentiation marker) in human U87MG cells over time. Numerous investigations have demonstrated that RES has anticancer properties at the level of posttranscriptional gene expression regulation [ 127 ]. Thrombotic Thrombocytopenic Purpura (TTP) is an RNA binding protein that binds to AU-rich regions in target mRNAs and promotes the deadenylating and destruction of target transcripts, including proto-oncogenes, antiapoptotic genes, immune regulatory genes, and others.…”

Section: Control Of Cellular Proliferation Apoptosis and Differentiationmentioning

confidence: 99%

Involvement of Resveratrol against Brain Cancer: A Combination Strategy with a Pharmaceutical Approach

et al. 2022

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A brain tumor (BT) is a condition in which there is growth or uncontrolled development of the brain cells, which usually goes unrecognized or is diagnosed at the later stages. Since the mechanism behind BT is not clear, and the various physiological conditions are difficult to diagnose, the success rate of BT is not very high. This is the central issue faced during drug development and clinical trials with almost all types of neurodegenerative disorders. In the first part of this review, we focus on the concept of brain tumors, their barriers, and the types of delivery possible to target the brain cells. Although various treatment methods are available, they all have side effects or toxic effects. Hence, in the second part, a correlation was made between the use of resveratrol, a potent antioxidant, and its advantages for brain diseases. The relationship between brain disease and the blood–brain barrier, multi-drug resistance, and the use of nanomedicine for treating brain disorders is also mentioned. In short, a hypothetical concept is given with a background investigation into the use of combination therapy with resveratrol as an active ingredient, the possible drug delivery, and its formulation-based approach.

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“…MicroRNAs (miRNAs) play important roles in regulating cell apoptosis, migration, and lipid metabolism during the development of NAFLD [ 108 ], which may function as diagnosis markers (e.g., miR-144-3p and miR-200b-3p) [ 109 ]. Keeping the balance of Th17/Treg ratio via modulating miR-195 expression can inhibit CD40 expression to ameliorate NAFLD in rats.…”

Section: Treatment Options For Nafld and Nash Based On Modulation Of Gut Microbiota Intrahepatic Immunity And Metabolic Signaling Pathwaymentioning

confidence: 99%

Diet and Gut Microbiota Interaction-Derived Metabolites and Intrahepatic Immune Response in NAFLD Development and Treatment

Yang

Khoukaz

et al. 2021

Biomedicines

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Nonalcoholic fatty liver disease (NAFLD) with pathogenesis ranging from nonalcoholic fatty liver (NAFL) to the advanced form of nonalcoholic steatohepatitis (NASH) affects about 25% of the global population. NAFLD is a chronic liver disease associated with obesity, type 2 diabetes, and metabolic syndrome, which is the most increasing factor that causes hepatocellular carcinoma (HCC). Although advanced progress has been made in exploring the pathogenesis of NAFLD and penitential therapeutic targets, no therapeutic agent has been approved by Food and Drug Administration (FDA) in the United States. Gut microbiota-derived components and metabolites play pivotal roles in shaping intrahepatic immunity during the progression of NAFLD or NASH. With the advance of techniques, such as single-cell RNA sequencing (scRNA-seq), each subtype of immune cells in the liver has been studied to explore their roles in the pathogenesis of NAFLD. In addition, new molecules involved in gut microbiota-mediated effects on NAFLD are found. Based on these findings, we first summarized the interaction of diet-gut microbiota-derived metabolites and activation of intrahepatic immunity during NAFLD development and progression. Treatment options by targeting gut microbiota and important molecular signaling pathways are then discussed. Finally, undergoing clinical trials are selected to present the potential application of treatments against NAFLD or NASH.

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Targeting miRNA by Natural Products: A Novel Therapeutic Approach for Nonalcoholic Fatty Liver

Cited by 13 publications

References 158 publications

Berberine Inhibits Dengue Virus through Dual Mechanisms

Berberine Inhibits Dengue Virus through Dual Mechanisms

Involvement of Resveratrol against Brain Cancer: A Combination Strategy with a Pharmaceutical Approach

Diet and Gut Microbiota Interaction-Derived Metabolites and Intrahepatic Immune Response in NAFLD Development and Treatment

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