Targeting MCAM for next-generation modulation of leucocyte trafficking

Schneider‐Hohendorf, Tilman; Wiendl, Heinz

doi:10.1093/brain/awad079

Brain

2023

DOI: 10.1093/brain/awad079

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Targeting MCAM for next-generation modulation of leucocyte trafficking

Tilman Schneider‐Hohendorf

Heinz Wiendl

Abstract: This scientific commentary refers to ‘MCAM+ brain endothelial cells contribute to neuroinflammation by recruiting pathogenic CD4+ T lymphocytes’ by Charabati et al. (https://doi.org/10.1093/brain/awac389).

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2023

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Learning CNS immunopathology from therapeutic interventions

Schwab,

Wiendl

2023

Sci. Transl. Med.

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Modulation of immune cell trafficking across the blood-brain barrier has not only introduced a therapeutic avenue for multiple sclerosis (MS) but also represents an example of reverse translational medicine. Data from clinical trials of drugs such as natalizumab and fingolimod have revealed the involvement of different compartments in relapsing versus non-relapsing MS immune biology, contributed to our understanding of central nervous system (CNS) immune surveillance, and stimulated new fields of research. Here, we discuss the results of these trials, as well as patient biomaterial-based scientific projects, and how both have informed our understanding of CNS immunopathology.

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Learning CNS immunopathology from therapeutic interventions

Schwab,

Wiendl

2023

Sci. Transl. Med.

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Targeting MCAM for next-generation modulation of leucocyte trafficking

Abstract: This scientific commentary refers to ‘MCAM+ brain endothelial cells contribute to neuroinflammation by recruiting pathogenic CD4+ T lymphocytes’ by Charabati et al. (https://doi.org/10.1093/brain/awac389).

Cited by 1 publication

References 10 publications

Learning CNS immunopathology from therapeutic interventions

Learning CNS immunopathology from therapeutic interventions

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