Targeting Macrophages: Therapeutic Approaches in Diabetic Kidney Disease
Da-Wei Lin,
Tsung-Ming Yang,
Cheng Ho
et al.
Abstract:Diabetes is not solely a metabolic disorder but also involves inflammatory processes. The immune response it incites is a primary contributor to damage in target organs. Research indicates that during the initial phases of diabetic nephropathy, macrophages infiltrate the kidneys alongside lymphocytes, initiating a cascade of inflammatory reactions. The interplay between macrophages and other renal cells is pivotal in the advancement of kidney disease within a hyperglycemic milieu. While M1 macrophages react to… Show more
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