2014
DOI: 10.15252/emmm.201404170
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Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions

Abstract: Macrophages are key immune cells found in atherosclerotic plaques and critically shape atherosclerotic disease development. Targeting the functional repertoire of macrophages may hold novel approaches for future atherosclerosis management. Here, we describe a previously unrecognized role of the epigenomic enzyme Histone deacetylase 3 (Hdac3) in regulating the atherosclerotic phenotype of macrophages. Using conditional knockout mice, we found that myeloid Hdac3 deficiency promotes collagen deposition in atheros… Show more

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Cited by 139 publications
(149 citation statements)
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References 34 publications
(41 reference statements)
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“…42 Other epigenetic marks besides DNA methylation may participate in plaque rupture, as the histone deacetylase HDAC3 has been recently shown to silence genes that favor plaque stability. 43 Further studies in specific cell populations within lesions are warranted to assess the pathobiological relevance of the candidate plaque rupture-associated DNA methylation profiles presented here.…”
Section: Discussionmentioning
confidence: 97%
“…42 Other epigenetic marks besides DNA methylation may participate in plaque rupture, as the histone deacetylase HDAC3 has been recently shown to silence genes that favor plaque stability. 43 Further studies in specific cell populations within lesions are warranted to assess the pathobiological relevance of the candidate plaque rupture-associated DNA methylation profiles presented here.…”
Section: Discussionmentioning
confidence: 97%
“…[142][143][144][145][146][147] Identification and characterization of common epigenetic outcomes linked to disease manifestations and their interaction with nutrient status may allow the development of specific treatment and intervention measures. [148][149][150][151] Interestingly, the effect of limited or oversaturated nutrient bioavailability on epigenetic states is complex and not necessarily direct. For example, deficiency of methyl donors results in hypermethylation at some loci and hypomethylation at others.…”
Section: Role Of Nutrition In Epigenetic Perturbationmentioning
confidence: 99%
“…Chromatin immunoprecipitation (ChIP) was performed, as described elsewhere (23). For AcH3 ChIP, 12 3 10 6 cells were used.…”
Section: Chromatin Immunoprecipitationmentioning
confidence: 99%