2023
DOI: 10.1002/ctm2.1229
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Targeting lysosomal HSP70 induces acid sphingomyelinase‐mediated disturbance of lipid metabolism and leads to cell death in T cell malignancies

Abstract: Find a new lysosomotropic drug V8.• The characteristics of targeting lysosome HSP70 are clarified.• Disturbance of lysosomal lipid metabolism is a new approach for T cell malignancies.• The HSP70-ASM axis regulates lysosomal stability.

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