Targeting lncRNAs of colorectal cancers with natural products

Abstract

Non-coding RNA (ncRNA) is one of the functional classes of RNA that has a regulatory role in various cellular processes, such as modulation of disease onset, progression, and prognosis. ncRNAs, such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have been actively studied in recent years. The change in ncRNA levels is being actively studied in numerous human diseases, especially auto-immune disorders and cancers; however, targeting and regulating ncRNA with natural products to cure cancer has not been fully established. Recently many groups reported the relationship between ncRNA and natural products showing promising effects to serve as additional therapeutic approaches to cure cancers. This mini-review summarizes the aspects of lncRNAs related to cancer biology focusing on colorectal cancers that natural products can target.

A pan-cancer analysis indicates long noncoding RNA HAND2-AS1 as a potential prognostic, immunomodulatory and therapeutic biomarker in various cancers including colorectal adenocarcinoma

“…Additionally, in the intricate network of cancer dynamics, lncRNAs can either function as tumor suppressors or oncogenes, orchestrating the modulation of their target mRNAs. This phenomenon is especially pronounced in CRC and other malignancies [27]. Based on our team's previous studies aimed at identifying important biomarkers in CRC, we performed a comprehensive transcriptome analysis of lncRNA-mRNA interactions to identify further biomarkers that could aid in the diagnosis, treatment, and prognosis of this disease [28][29][30].…”

A pan-cancer analysis indicates long noncoding RNA HAND2-AS1 as a potential prognostic, immunomodulatory and therapeutic biomarker in various cancers including colorectal adenocarcinoma

“…Additionally, in the intricate network of cancer dynamics, lncRNAs can either function as tumor suppressors or oncogenes, orchestrating the modulation of their target mRNAs. This phenomenon is especially pronounced in CRC and other malignancies [ 24 ]. Based on our team’s previous studies aimed at identifying important biomarkers in CRC, we performed a comprehensive transcriptome analysis of lncRNA–mRNA interactions to identify further biomarkers that could aid in the diagnosis, treatment, and prognosis of this disease [ 25 – 27 ].…”

Nanotherapeutic approaches for delivery of long non-coding RNAs: an updated review with emphasis on cancer

“…167,169 There are more than 80 lncRNAs directly or indirectly associated with CRC. 170 Exosomal lncRNAs may stimulate the production of PMNs in cancer and stromal cells, thereby promoting disease progression. As one method, they convert inflammatory and immunosuppressive factors into tumor-associated macro-phages (TAMs) and CAFs during inflammatory or immunosuppressive conditions.…”