Targeting lactate-related cell cycle activities for cancer therapy

Histone lactylation bridges metabolic reprogramming and epigenetic rewiring in driving carcinogenesis: Oncometabolite fuels oncogenic transcription

“…Studies have recorded that the application of oxamate to lymphoma cells hinders the advancement of acute lymphoblastic leukaemia cells Jurkat and DU528 117 . According to records, oxamate has been observed to hinder the growth of cells in nasopharyngeal and gastric cancer 118 . Gossypol, FX11 and quinoline 3‐sulphonamides are part of the group of LDHA inhibitors that compete with nicotinamide adenine dinucleotide.…”

“…Gossypol, FX11 and quinoline 3‐sulphonamides are part of the group of LDHA inhibitors that compete with nicotinamide adenine dinucleotide. Several research studies have extensively recorded the effectiveness of these in inhibiting the proliferation of different types of cancer cells, such as those found in the colon, neuroblastoma, HCC, primary pancreatic cancer, melanoma and breast cancer 118 . Furthermore, N‐hydroxyindole‐based inhibitor of lactated dehydrogenase (NHI), galloflavin and [(R)‐3‐((2‐chlorophenyl)thio)‐4‐hydroxy‐6‐(4‐morpholinophenyl)‐6‐(thiophen‐3‐yl)‐5,6‐dihydropyridin‐2(1H)‐one] ((R)‐GNE‐140), functioning as LDHA inhibitors that compete with NADH, have exhibited the capability to impede the growth of cancerous cells, particularly those found in pancreatic and colorectal cancer.…”

“…117 According to records, oxamate has been observed to hinder the growth of cells in nasopharyngeal and gastric cancer. 118 Gossypol, FX11 and quinoline 3-sulphonamides are part of the group of LDHA inhibitors that compete with nicotinamide adenine dinucleotide. Several research studies have extensively recorded the effectiveness of these in inhibiting the proliferation of different types of cancer cells, such as those found in the colon, neuroblastoma, HCC, primary pancreatic cancer, melanoma and breast cancer.…”

“…Several research studies have extensively recorded the effectiveness of these in inhibiting the proliferation of different types of cancer cells, such as those found in the colon, neuroblastoma, HCC, primary pancreatic cancer, melanoma and breast cancer. 118 Several specific compounds, such as 1-(phenylseleno)-4-(trifluoromethyl) benzene (PSTMB), phthalimide and dibenzofuran derivatives, have shown the ability to function as LDHA inhibitors, effectively impeding the development and multiplication of cancer cells. 119 Particularly noteworthy are the novel LDH inhibitors, phthalimide and dibenzofuran derivatives, which display selective inhibition towards the LDHA isoenzyme.…”

Imaging glucose metabolism to reveal tumor progression

“…Metabolic reprogramming is a cancer characteristic in which cells are rewired to enable optimized neoplastic development ( Madhavan and Nagarajan, 2020 ; Lin et al, 2022 ). Typically, differentiated cells rely on oxidative phosphorylation within mitochondria to produce the energy required for cellular processes.…”