Targeting Inflammation in the Diagnosis, Management, and Prevention of Cardiovascular Diseases

Matsumori, Akira

doi:10.5334/gh.1156

Cited by 6 publications

(17 citation statements)

References 68 publications

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“…We thus hypothesized that deficiency in pro‐resolving pathway may accelerate cardiovascular senescence, adverse remodeling, and dysfunction. Our results demonstrate deficiency of pro‐resolving mediator ANXA1 exaggerated cardiovascular damage, cardiac senescence, and inflammation in middle‐aged mice compared to mature mice, suggesting that unresolved inflammation may contribute to cardiovascular dysfunction in aging, consistent with clinical reports 66,67 …”

Section: Discussionsupporting

confidence: 89%

“…Our results demonstrate deficiency of pro-resolving mediator ANXA1 exaggerated cardiovascular damage, cardiac senescence, and inflammation in middle-aged mice compared to mature mice, suggesting that unresolved inflammation may contribute to cardiovascular dysfunction in aging, consistent with clinical reports. 66,67 In this study, blood pressure was higher in conscious ANXA1 −/− mice at 4 months of age compared to wild-type, and this was maintained in ANXA1 −/− mice at 12 months of age. This elevation of BP might be attributed to greater vascular calcification and lower vascular distensibility.…”

Section: Discussionmentioning

confidence: 48%

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The pro‐resolving mediator, annexin A1 regulates blood pressure, and age‐associated changes in cardiovascular function and remodeling

Singh,

Jackson,

Tang

et al. 2024

The FASEB Journal

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Aging is associated with chronic, low‐level inflammation which may contribute to cardiovascular pathologies such as hypertension and atherosclerosis. This chronic inflammation may be opposed by endogenous mechanisms to limit inflammation, for example, by the actions of annexin A1 (ANXA1), an endogenous glucocorticoid‐regulated protein that has anti‐inflammatory and pro‐resolving activity. We hypothesized the pro‐resolving mediator ANXA1 protects against age‐induced changes in blood pressure (BP), cardiovascular structure and function, and cardiac senescence. BP was measured monthly in conscious mature (4‐month) and middle‐aged (12‐month) ANXA1‐deficient (ANXA1−/−) and wild‐type C57BL/6 mice. Body composition was measured using EchoMRI, and both cardiac and vascular function using ultrasound imaging. Cardiac hypertrophy, fibrosis and senescence, vascular fibrosis, elastin, and calcification were assessed histologically. Gene expression relevant to structural remodeling, inflammation, and cardiomyocyte senescence were also quantified. In C57BL/6 mice, progression from 4 to 12 months of age did not affect the majority of cardiovascular parameters measured, with the exception of mild cardiac hypertrophy, vascular calcium, and collagen deposition. Interestingly, ANXA1−/− mice exhibited higher BP, regardless of age. Additionally, age progression had a marked impact in ANXA1−/− mice, with markedly augmented vascular remodeling, impaired vascular distensibility, and body composition. Consistent with vascular dysfunction, cardiac dysfunction, and hypertrophy were also evident, together with markers of senescence and inflammation. These findings suggest that endogenous ANXA1 plays a critical role in regulating BP, cardiovascular function, and remodeling and delays cardiac senescence. Our findings support the development of novel ANXA1‐based therapies to prevent age‐related cardiovascular pathologies.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 48%

The pro‐resolving mediator, annexin A1 regulates blood pressure, and age‐associated changes in cardiovascular function and remodeling

Singh,

Jackson,

Tang

et al. 2024

The FASEB Journal

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“…Previous researchers have posited that the continued presence of TNFα throughout the latter stages of MI might potentially have a role in the loss of cardiac myocytes and subsequent cardiac decompensation. 67 In our dataset, it was discovered that patients with higher levels of TNFΑ were more likely to die from coronary disease and have recurrent MI. These results thus lend credence to the idea that inflammation plays a substantial role in the development of acute coronary syndromes, 68,69 as well as having long-term prognostic value among apparently stable patients.…”

Section: Discussionmentioning

confidence: 80%

Evaluation of Tumor Necrosis Factor Alpha, Insulin, glucose, HbA1c% and HOMA-IR as Predictors for Cardiovascular Diseases in Patients with Type 2 Diabetes

Jabber,

Charfeddine,

Abbas

2024

Pharmacogn J.

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Objective: Comparison of the blood level of TNFα in patients with and without type 2 diabetes who have cardiovascular diseases. Examine the connection between the amount of serum TNFα and insulin resistance in patients with type 2 diabetes who have cardiovascular diseases. Method: The present study included 60 patients with Diabetes Mellitus (DM) with a mean age of 56.02±1.395 years and an age range of (40 -80)years and 60 patients with cardiovascular diseases and diabetes (CVD and DM) with a mean age of 59.20±1.478 and an age range of (40-80) years, Who visited Al-Basrah Teaching Hospital in Basrah. in addition, the study included 60 healthy controls mean age of healthy control subjects was 54.72±1.405years. All patients in this study were diagnosed by specialized doctors and the diagnosis was verified by clinical and laboratory tests, during the period from September 2022 to September 2023. All Subjects signed a written informed consent form. The BMI was calculated as body weight (kg) and was divided by squared height in meters. Results: The results of this study showed an increase in the level of glucose, haemoglobin A1c%, insulin, and HOMA IR (in CVD and DM patients as compared with DM patients and control and there was a significant difference in concentrations among study groups (p-value <0.0001). Also, The results of this study showed an increase in the level of tumor necrosis factor-alpha in CVD and DM patients as compared with DM and control and there was a significant difference in concentrations of TNFα among study groups (p-value <0.0001). Conclusion: Based on the findings of this research, it can be inferred that TNFα and HbA1c have the potential to serve as practical and straightforward indicators for predicting the coexistence of insulin resistance, dysglycemia, and Cardiovascular Diseases in seemingly healthy individuals within the young (<50 years) Al-Basra community.

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“…Inflammation plays an important role in the development and progression of cardiovascular diseases (CVDs). Hypertension and hyperlipidemia, the key risk factors of CVDs, are related to inflammation in the heart and vessels ( 144 ). The signaling pathways mediated by immune and inflammatory mediators have been implicated within the atherosclerotic lesion ( 145 ).…”

Section: Ba Metabolites and Immune-associated Disordersmentioning

confidence: 99%

Gut microbiota derived bile acid metabolites maintain the homeostasis of gut and systemic immunity

Gao

Yang

2023

Front. Immunol.

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Bile acids (BAs) as cholesterol-derived molecules play an essential role in some physiological processes such as nutrient absorption, glucose homeostasis and regulation of energy expenditure. They are synthesized in the liver as primary BAs such as cholic acid (CA), chenodeoxycholic acid (CDCA) and conjugated forms. A variety of secondary BAs such as deoxycholic acid (DCA) and lithocholic acid (LCA) and their derivatives is synthesized in the intestine through the involvement of various microorganisms. In addition to essential physiological functions, BAs and their metabolites are also involved in the differentiation and functions of innate and adaptive immune cells such as macrophages (Macs), dendritic cells (DCs), myeloid derived suppressive cells (MDSCs), regulatory T cells (Treg), Breg cells, T helper (Th)17 cells, CD4 Th1 and Th2 cells, CD8 cells, B cells and NKT cells. Dysregulation of the BAs and their metabolites also affects development of some diseases such as inflammatory bowel diseases. We here summarize recent advances in how BAs and their metabolites maintain gut and systemic homeostasis, including the metabolism of the BAs and their derivatives, the role of BAs and their metabolites in the differentiation and function of immune cells, and the effects of BAs and their metabolites on immune-associated disorders.

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Targeting Inflammation in the Diagnosis, Management, and Prevention of Cardiovascular Diseases

Cited by 6 publications

References 68 publications

The pro‐resolving mediator, annexin A1 regulates blood pressure, and age‐associated changes in cardiovascular function and remodeling

The pro‐resolving mediator, annexin A1 regulates blood pressure, and age‐associated changes in cardiovascular function and remodeling

Evaluation of Tumor Necrosis Factor Alpha, Insulin, glucose, HbA1c% and HOMA-IR as Predictors for Cardiovascular Diseases in Patients with Type 2 Diabetes

Gut microbiota derived bile acid metabolites maintain the homeostasis of gut and systemic immunity

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