Targeting human telomeric G-quadruplex DNA with curcumin and its synthesized analogues under molecular crowding conditions

Abstract

The formation of telomeric G-quadruplexes has been shown to inhibit telomerase activity.

Recent Updates in Curcumin Pyrazole and Isoxazole Derivatives: Synthesis and Biological Application

“…al [70] synthesized a number of analogs of curcumin and studied the effects of substituents and chemical nature of the interaction of curcumin to Gquadruplex. al [70] synthesized a number of analogs of curcumin and studied the effects of substituents and chemical nature of the interaction of curcumin to Gquadruplex.…”

“…Jha et. al [70] synthesized a number of analogs of curcumin and studied the effects of substituents and chemical nature of the interaction of curcumin to Gquadruplex. Curcumin stabilized the quadruplex structure of telomeric DNA sequence while curcumin pyrazole and 3-nitrophenyl curcumin pyrazole analogs were reported for its conformation.…”

Exploring the preferential interaction of quercetin with VEGF promoter G-quadruplex DNA and construction of a pH-dependent DNA-based logic gate

“…Different classes of small molecules including alkaloids, 17 curcuminoids, 18 avonoids, 19,20 and acriavines 21 have been investigated as antiparallel and/or mixed-hybrid G4-DNA specic ligand in comparison to double-stranded DNA. Studies on the interactions of alkaloids and avonoids of different classes (avone, isoavone, avanone and avan-3-ol) with parallel G4-DNA sequence have also been reported.…”

Targeting human telomeric DNA with azacyanines

“…The interactions of azacyanines with tel24 were first investigated using UV-Vis and circular dichroism (CD) spectroscopy in order to quickly survey and confirm the presence of interactions between the azacyanines and tel24. Such a survey also reveals changes in the secondary structure of tel24 upon azacyanine binding and the effect of azacyanine structure on tel24 binding [25,[28][29][30][31][32][33][34][35][36][37]. Our previous structural studies using NMR have shown that one azamethyl was binding to one tel24 G-quadruplex structure between the top quartet and the A-T base pairing in the loop region.…”

“…Several studies investigating the effect of the benzimidazole scaffold on telomeric DNA and oncogene promoters such as KRAS and VEGFR that are known to fold into quadruplex structures were recently reported [24][25][26][27][28][29][30]. In addition, several reports investigating the effect of such small molecules on different cancer lines and promoting G-quadruplexes as plausible targets in cancer therapy were also published [31][32][33][34][35][36]. Based on all these reported studies and our knowledge on azamethyl, we were inspired to explore a series of azacyanine compounds as potential G-quadruplex stabilizing compounds with the hope of finding a better candidate than azamethyl and understanding the effect of molecular structure on molecular recognition.…”