2021
DOI: 10.3390/ijms22179143
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Targeting Human Papillomavirus-Associated Cancer by Oncoprotein-Specific Recombinant Antibodies

Abstract: In recent decades, recombinant antibodies against specific antigens have shown great promise for the therapy of infectious diseases and cancer. Human papillomaviruses (HPVs) are involved in the development of around 5% of all human cancers and HPV16 is the high-risk genotype with the highest prevalence worldwide, playing a dominant role in all HPV-associated cancers. Here, we describe the main biological activities of the HPV16 E6, E7, and E5 oncoproteins, which are involved in the subversion of important regu… Show more

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Cited by 6 publications
(4 citation statements)
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References 102 publications
(125 reference statements)
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“…During this time, many antibodies aimed at abolishing E6’s functions have been raised against the HPV16 E6 protein almost entirely for therapeutic purposes. Recently, anti-E6 antibodies have been reviewed focusing on their formats, therapeutic proprieties, and delivery methods (Donà et al 2021). Although some antibodies have shown therapeutic potential, the search for more efficient molecules with higher therapeutic capacity is still ongoing.…”
Section: Resultsmentioning
confidence: 99%
“…During this time, many antibodies aimed at abolishing E6’s functions have been raised against the HPV16 E6 protein almost entirely for therapeutic purposes. Recently, anti-E6 antibodies have been reviewed focusing on their formats, therapeutic proprieties, and delivery methods (Donà et al 2021). Although some antibodies have shown therapeutic potential, the search for more efficient molecules with higher therapeutic capacity is still ongoing.…”
Section: Resultsmentioning
confidence: 99%
“…Oncoproteins are constitutively produced at high levels in tumor cells and are not found elsewhere in the human body, which distinguishes HPV-associated cancers [41,43]. This constitutive production makes them an excellent target for the therapeutic vaccines designed to provoke a specific antitumor response, targeting cells that express the antigens and limiting the danger of harming healthy tissue [44].…”
Section: Therapeutic Vaccines For Hpv-associated Malignanciesmentioning
confidence: 99%
“…HPV potentially contributes to PCa development and chronic inflammation [5,9]. 5% of human cancers are related to HPV, and in meantime, HPV16, which is one of the most dangerous types of HPV with the highest prevalence in the world, plays a prominent role in all HPV-related cancers [10]. HPV infection is associated with some cancers, including cervix carcinomas, vulva, vagina, anal, head and neck, and penile cancers [11].…”
Section: Introductionmentioning
confidence: 99%