Targeting Hippo/YAP in intrahepatic cholangiocarcinoma: Promising molecules in cancer therapy
Xing Ma,
Yangyang Zhou,
Ruping Li
et al.
Abstract:The tumorigenesis of intrahepatic cholangiocarcinoma (ICC) has been identified to be exceptionally involved in dysregulated Hippo/Yes‐associated protein (YAP) signaling pathway (Hippo/YAP). Hippo/YAP functions as a master regulator engaged in a plethora of physiological and oncogenic processes as well. Therefore, the aberrant Hippo/YAP could serve as an Achilles' heel regarding the molecular therapeutic avenues for ICC patients. Herein, we comprehensively review the recent studies about the underlying mechanis… Show more
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