Targeting HIF-1α/NOTCH1 pathway eliminates CD44+ cancer stem-like cell phenotypes, malignancy, and resistance to therapy in head and neck squamous cell carcinoma

Byun, Joo‐Yun; Huang, Kun; Lee, Jong Suk; Huang, Wenjie; Hu, Li; Zheng, Xuyu; Tang, Xin; Li, Feng‐Zeng; Jo, Dong Gyu; Song, Xinmao; Huang, Chuang

doi:10.1038/s41388-021-02166-w

Cited by 18 publications

(12 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hyaluronic acid-mediated signalling of CD44 associated with tumor metastasis have been widely studied [ 14 ]. A recent study showed that downregulating the HIF-1α/NOTCH-1 pathway was able to eliminate CD44 + cancer stem-like cell phenotypes to enhance the malignancy and chemo-resistance in neck squamous cell carcinomas [ 36 ]. A previous study has clarified that KIF-18B was involved in the growth and progression of tumor cells by up-regulating transcription of CDCA8 [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

CDCA8/SNAI2 Complex Activates CD44 to Promote Proliferation and Invasion of Pancreatic Ductal Adenocarcinoma

Guo

et al. 2022

Cancers

View full text Add to dashboard Cite

(1) Background: Recently, cell division cycle associated 8 (CDCA8) was found to be overexpressed in pancreatic ductal adenocarcinoma (PDAC). Here, we aimed to explore the specific mechanism of action of CDCA8 in PDAC progression. (2) Methods: All human PDAC samples and clinical data were collected from Huashan Hospital, Fudan University. All experimental studies were carried out using many in vitro and in vivo assays, including lentiviral transfection, real-time quantitative polymerase chain reaction (qPCR), western blotting, co-immunoprecipitation (Co-IP), chromatin IP (ChIP)-qPCR, dual-luciferase reporter, and in vivo imaging assays. (3) Results: Clinical data analysis of human PDAC samples revealed that CDCA8 overexpression were positively and negatively associated with tumor grade (p = 0.007) and overall survival (p = 0.045), respectively. CDCA8 knockdown inhibited PDAC proliferation and invasion in in vitro and in vivo assays. CD44 was also up-regulated by CDCA8 during PDAC progression. CDCA8 could be combined with SNAI2 to form a CDCA8/SNAI2 complex to integrate with the CD44 promoter as indicated through ChIP-qPCR and dual-luciferase reporter assays. (4) Conclusion: We showed that CDCA8-CD44 axis plays a key role in the proliferation and invasion of PDAC, which provides a potential target for treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

CDCA8/SNAI2 Complex Activates CD44 to Promote Proliferation and Invasion of Pancreatic Ductal Adenocarcinoma

Guo

et al. 2022

Cancers

View full text Add to dashboard Cite

show abstract

“…Inhibiting the expression of HIF-1α can inhibit the expression of NOTCH1 and block the metastasis rate and chemotherapy resistance of HNSCC cells. Therefore, NOTCH1 plays an essential role in maintaining the characteristics of HNSCC cells, promoting the malignancy of HNSCC cells and drug resistance to chemotherapy and radiation [ 161 ].…”

Section: Modulation Of Cell Death In Hnsccmentioning

confidence: 99%

Effect of regulatory cell death on the occurrence and development of head and neck squamous cell carcinoma

et al. 2023

View full text Add to dashboard Cite

Head and neck cancer is a malignant tumour with a high mortality rate characterized by late diagnosis, high recurrence and metastasis rates, and poor prognosis. Head and neck squamous cell carcinoma (HNSCC) is the most common type of head and neck cancer. Various factors are involved in the occurrence and development of HNSCC, including external inflammatory stimuli and oncogenic viral infections. In recent years, studies on the regulation of cell death have provided new insights into the biology and therapeutic response of HNSCC, such as apoptosis, necroptosis, pyroptosis, autophagy, ferroptosis, and recently the newly discovered cuproptosis. We explored how various cell deaths act as a unique defence mechanism against cancer emergence and how they can be exploited to inhibit tumorigenesis and progression, thus introducing regulatory cell death (RCD) as a novel strategy for tumour therapy. In contrast to accidental cell death, RCD is controlled by specific signal transduction pathways, including TP53 signalling, KRAS signalling, NOTCH signalling, hypoxia signalling, and metabolic reprogramming. In this review, we describe the molecular mechanisms of nonapoptotic RCD and its relationship to HNSCC and discuss the crosstalk between relevant signalling pathways in HNSCC cells. We also highlight novel approaches to tumour elimination through RCD.

show abstract

“…For example, Kimberly J Briggs et al found that HIFα promotes adaptation to hypoxia and stimulates growth in triple-negative breast cancer [ 16 ]. Joo-Yun Byun et al found that HIF-1α promotes cancer stem-like cell phenotype and chemotherapy resistance in head and neck squamous cell carcinoma [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…Molecules 2022, 27, x FOR PEER REVIEW 2 of 14 and stimulates growth in triple-negative breast cancer [16]. Joo-Yun Byun et al found that HIF-1α promotes cancer stem-like cell phenotype and chemotherapy resistance in head and neck squamous cell carcinoma [17]. According to the data of the World Health Organization, the number of new gastric cancer patients in the world in 2020 is 1.09 million, ranking fifth, and the number of gastric cancer deaths in the world in 2020 is 770,000, ranking fourth.…”

Section: Introductionmentioning

confidence: 99%

HIF in Gastric Cancer: Regulation and Therapeutic Target

Guan

Yang

et al. 2022

Molecules

View full text Add to dashboard Cite

HIF means hypoxia-inducible factor gene family, and it could regulate various biological processes, including tumor development. In 2021, the FDA approved the new drug Welireg for targeting HIF-2a, and it is mainly used to treat von Hippel-Lindau syndrome, which demonstrated its good prospects in tumor therapy. As the fourth deadliest cancer worldwide, gastric cancer endangers the health of people all across the world. Currently, there are various treatment methods for patients with gastric cancer, but the five-year survival rate of patients with advanced gastric cancer is still not high. Therefore, here we reviewed the regulatory role and target role of HIF in gastric cancer, and provided some references for the treatment of gastric cancer.

show abstract

Targeting HIF-1α/NOTCH1 pathway eliminates CD44+ cancer stem-like cell phenotypes, malignancy, and resistance to therapy in head and neck squamous cell carcinoma

Cited by 18 publications

References 51 publications

CDCA8/SNAI2 Complex Activates CD44 to Promote Proliferation and Invasion of Pancreatic Ductal Adenocarcinoma

CDCA8/SNAI2 Complex Activates CD44 to Promote Proliferation and Invasion of Pancreatic Ductal Adenocarcinoma

Effect of regulatory cell death on the occurrence and development of head and neck squamous cell carcinoma

HIF in Gastric Cancer: Regulation and Therapeutic Target

Contact Info

Product

Resources

About