Targeting GSTP1-dependent ferroptosis in lung cancer radiotherapy: Existing evidence and future directions

Tan, Xin; Huang, Xiang; Niu, Baolong; Guo, Xingdong; Xiao, Lanbo; Qu, Baolin

doi:10.3389/fmolb.2022.1102158

Cited by 10 publications

(6 citation statements)

References 98 publications

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“…Finally, catalysed by lipoxygenase (LOX), PUFAs‐PE can be oxidised, contributing to lipid peroxidation and thereby inducing ferroptosis. 46 Therefore, the expressions of ACSL4 in those ferroptosis‐sensitive cells such as HepG2 and HL60 are higher than that in such ferroptosis‐resistant cells as LNCaP as well as K562. 47 In addition, compared with control MLE cells, LPCAT3 knockdown MLE cells are resistant to RSL3‐induced ferroptosis, showing lower rate of cell death.…”

Section: Overview Of Ferroptosismentioning

confidence: 94%

“…Subsequently, LPCAT3 combines PUFAs‐CoA with PE, thus producing PUFAs‐PE. Finally, catalysed by lipoxygenase (LOX), PUFAs‐PE can be oxidised, contributing to lipid peroxidation and thereby inducing ferroptosis 46 . Therefore, the expressions of ACSL4 in those ferroptosis‐sensitive cells such as HepG2 and HL60 are higher than that in such ferroptosis‐resistant cells as LNCaP as well as K562 47 .…”

Section: Overview Of Ferroptosismentioning

confidence: 99%

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Research progress and insights on the role of ferroptosis in wound healing

Zhang

2023

International Wound Journal

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Ferroptosis is a newly discovered cell death type which is different from apoptosis, autophagy, pyroptosis as well as necrosis in the following aspects: morphology, biochemistry, gene and regulatory mechanisms. Ferroptosis is regulated by multiples of mechanisms such as system Xc À mechanism, glutathione peroxidase 4 (GPX4) mechanism, iron metabolism and lipid metabolism. Currently, ferroptosis has been revealed to be significant in wound healing such as diabetic wound, irradiated wound and ultraviolet (UV)-driven wound. Hence, how to intervene in the pathogenesis as well as the development of wounds and promote the wound healing by the regulation of ferroptosis have become a research hotspot. This review systematically summarises the latest scientific advances of ferroptosis and wound healing fields, with hoping to propose a new insight and advance in the wound treatment.biomaterials, diabetic wound, ferroptosis, iron metabolism, lipid peroxidation, wound healing Key Messages• ferroptosis is a newly discovered cell death type which has been revealed to be significant in wound healing such as diabetic wound, irradiated wound and UV-driven wound • we summarised the latest scientific advances of ferroptosis and wound healing fields, with hoping to propose a new insight and advance in the wound treatment

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Section: Overview Of Ferroptosismentioning

confidence: 94%

Section: Overview Of Ferroptosismentioning

confidence: 99%

Research progress and insights on the role of ferroptosis in wound healing

Zhang

2023

International Wound Journal

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“…However, there is insufficient evidence to determine whether immunotherapy for lung cancer could also be linked to ferroptosis. 113 , 116 Despite extensive research in recent years, the relationship between tumor immunity and ferroptosis, including its effects on tumor susceptibility, is not well understood.…”

Section: Ferroptosis In Respiratory Diseasesmentioning

confidence: 99%

Unraveling the Molecular Regulation of Ferroptosis in Respiratory Diseases

Zhu,

Zhou,

et al. 2024

JIR

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Ferroptosis, a type of programmed cell death that relies on iron, is distinct in terms of its morphological, biochemical and genetic features. Unlike other forms of cell death, such as autophagy, apoptosis, necrosis, and pyroptosis, ferroptosis is primarily caused by lipid peroxidation. Cells that die due to iron can potentially trigger an immune response which intensifies inflammation and causes severe inflammatory reactions that eventually lead to multiple organ failure. In recent years, ferroptosis has been identified in an increasing number of medical fields, including neurological pathologies, chronic liver diseases and sepsis. Ferroptosis has the potential to cause an inflammatory tempest, with many of the catalysts and pathological indications of respiratory ailments being linked to inflammatory reactions. The growing investigation into ferroptosis in respiratory disorders has also garnered significant interest to better understand the mechanism of ferroptosis in these diseases. In this review, the recent progress in understanding the molecular control of ferroptosis and its mechanism in different respiratory disorders is examined. In addition, this review discusses current challenges and prospects for understanding the link between respiratory diseases and ferroptosis.

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“…Another study in prostate cancer showed that piR-31470 forms a complex with piwi-like RNAmediated gene silencing 4 (PIWIL4) and then recruits DNMT1, DNA methyltransferase 3α, and methyl-CpG binding domain protein 2 to initiate and maintain the hypermethylation and inactivation of glutathione S-transferase P1 (GSTP1) [175]. Related studies have indicated that GSTP1 inactivation inhibits tumor cells from evading ferroptosis, leading to tumor growth [176], suggesting that piR-31470 may suppress ferroptosis through the inactivation of GSTP1.…”

Section: Pirnas In Ferroptosismentioning

confidence: 99%

The Regulation of Ferroptosis by Noncoding RNAs

Zheng,

Zhang

2023

IJMS

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As a novel form of regulated cell death, ferroptosis is characterized by intracellular iron and lipid peroxide accumulation, which is different from other regulated cell death forms morphologically, biochemically, and immunologically. Ferroptosis is regulated by iron metabolism, lipid metabolism, and antioxidant defense systems as well as various transcription factors and related signal pathways. Emerging evidence has highlighted that ferroptosis is associated with many physiological and pathological processes, including cancer, neurodegeneration diseases, cardiovascular diseases, and ischemia/reperfusion injury. Noncoding RNAs are a group of functional RNA molecules that are not translated into proteins, which can regulate gene expression in various manners. An increasing number of studies have shown that noncoding RNAs, especially miRNAs, lncRNAs, and circRNAs, can interfere with the progression of ferroptosis by modulating ferroptosis-related genes or proteins directly or indirectly. In this review, we summarize the basic mechanisms and regulations of ferroptosis and focus on the recent studies on the mechanism for different types of ncRNAs to regulate ferroptosis in different physiological and pathological conditions, which will deepen our understanding of ferroptosis regulation by noncoding RNAs and provide new insights into employing noncoding RNAs in ferroptosis-associated therapeutic strategies.

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Targeting GSTP1-dependent ferroptosis in lung cancer radiotherapy: Existing evidence and future directions

Cited by 10 publications

References 98 publications

Research progress and insights on the role of ferroptosis in wound healing

Research progress and insights on the role of ferroptosis in wound healing

Unraveling the Molecular Regulation of Ferroptosis in Respiratory Diseases

The Regulation of Ferroptosis by Noncoding RNAs

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