Targeting Groups Employed in Selective Dendrons and Dendrimers

Abstract

The design of compounds with directed action to a defined organ or tissue is a very promising approach, since it can decrease considerably the toxicity of the drug/bioactive compound. For this reason, this kind of strategy has been greatly important in the scientific community. Dendrimers, on the other hand, comprise extremely organized macromolecules with many peripheral functionalities, stepwise controlled synthesis, and defined size. These nanocomposites present several biological applications, demonstrating their efficiency to act in the pharmaceutical field. Considering that, the main purpose of this review was describing the potential of dendrons and dendrimers as drug targeting, applying different targeting groups. This application has been demonstrated through interesting examples from the literature considering the last ten years of publications.

A Review on Carbon Nanotubes Family of Nanomaterials and Their Health Field

“…It has been an effective tool in the treatment of pathological disorders, as it can increase the chemotherapeutic effect and decrease the toxicity in normal tissues. Therefore, CNTs have been explored in this field since drugs can be encapsulated within CNTs forming complexes or conjugates on their surfaces through covalent bonds that promote drug release …”

“…Therefore, CNTs have been explored in this field since drugs can be encapsulated within CNTs forming complexes or conjugates on their surfaces through covalent bonds that promote drug release. 121 As those nanocarriers are alternatives that can be used in drug delivery platforms, in this review we describe the use of CNT in this area, with emphasis on controlled and targeted drug delivery. 122−124 (a) CNT Prodrug Approaches for Delivery.…”

Recent Progress and Advances of Multi-Stimuli-Responsive Dendrimers in Drug Delivery for Cancer Treatment

“…Dendrimers, unlike traditional polymers, have been widely applied in biological processes because of their biocompatibility, high water solubility, precise molecular weight, and polyvalency [135]. These characteristics make dendrimers ideal carriers during drug delivery and targeting processes [12,21,92,136]. When evaluating the use of dendrimers in drug delivery, their biopermeability in various biological membranes should be considered.…”

“…Many terminal groups can derive from the formation of many bonds, linkages with the chemical reactions carried out from the focal point. Dendrons and their structures are often designated to be monodisperse and highly symmetric [12]. With the unique composition, dendrons are subjected specifically to orthogonal reactions serving different purposes.…”

Synthesis of Glycodendrimers with Antiviral and Antibacterial Activity

“…From the central core up to the surface, the number of ramificationp oints in one dendron corresponds to the number of dendrimer generations. [12] These glycodendri- [a] Dr.P .Hoyos, Dr.A .P erona, Dr.M.J.Hernµiz Chemistryi nP harmaceutical Sciences Department Complutense University of Madrid Plaza RamónyCajal s/n, 28040 Madrid (Spain) E-mail:mjhernai@ucm.es mers can be prepared through convergent or divergent iterative synthesis, leading to at ypically globulart opology that is mono-dispersed and mostly nanoscale in size.…”