Targeting granulocyte‐macrophage colony‐stimulating factor in epithelial and vascular remodeling in experimental eosinophilic esophagitis

Abstract

Granulocyte-macrophage colony-stimulating factor is a potential therapeutic target to reduce esophageal eosinophilia and remodeling.

Epithelial HIF-1α/claudin-1 axis regulates barrier dysfunction in eosinophilic esophagitis

“…Thermocycling and analysis were performed with an ABI-7300 System and software, and data calculated as relative quantification were normalized to 18S refs. 17,53).…”

Pathophysiology of Dysphagia in Eosinophilic Esophagitis: Causes, Consequences, and Management

“…Vascular proliferation results in mucosal edema while concurrently facilitating additional eosinophil recruitment by increasing vascular permeability [26,27]. Esophageal biopsies from patients with EoE exhibit higher levels of angiogenesis-promoting factors including VEGF, angiogenin, and IL-8: markers of activated vascular endothelium and increased vessel density [26][27][28]. Activated vessels and neovascularization result in dilated intercellular spaces and subsequent edema due to vascular leak [13].…”

Eosinophilic esophagitis: A review of the pediatric population and consideration of upcoming therapies

“…Another potential target in the treatment of EoE is granulocyte‐macrophage colony‐stimulating factor that is thought to play a role in the pathogenesis of EoE in connection with esophageal eosinophilia and epithelial remodeling in mouse models 71 . A group from Colorado has been evaluating the role of targeting granulocyte‐macrophage colony‐stimulating factor and observed significantly reduced epithelia eosinophilia, decreased basal cell hyperplasia, and decreased angiogenesis 71 . This is another potential avenue that shows promise in the management and treatment of EoE.…”

“…71 A group from Colorado has been evaluating the role of targeting granulocyte-macrophage colony-stimulating factor and observed significantly reduced epithelia eosinophilia, decreased basal cell hyperplasia, and decreased angiogenesis. 71 This is another potential avenue that shows promise in the management and treatment of EoE.…”