Targeting glutamine metabolism enhances tumor specific immunity by inhibiting the generation of MDSCs and reprogramming tumor associated macrophages

Oh, Min Hee; Sun, Im-Hong; Zhao, Liang; Leone, Robert D.; Sun, Im Meng; Xu, Wei; Collins, Samuel; Tam, Ada; Blosser, Richard L.; Patel, Chirag H.; Englert, Judson M.; Arwood, Matthew L.; Wen, Jiayu; Chan‐Li, Yee; Majer, Pavel; Rais, Rana; Slusher, Barbara S.; Horton, Maureen R.; Powell, Jonathan D.

doi:10.1101/656553

Cited by 1 publication

(1 citation statement)

References 73 publications

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“…In the next section, we discuss the influence of, metabolism with prime emphasis on fatty acid metabolism and storage in MDSC differentiation and their role in cancer progression. Reports by Min Lee Oh et al demonstrate that targeting glutamine metabolism in MDSCs leads to immunogenic cell death (ICD) of the tumor, decreases the recruitment and accumulation of MDSCs while increasing the number of pro-inflammatory macrophages [ 51 ]. A study conducted by Adeshakin et al confirmed the role of lipid accumulation in immunosuppressive MDSCs.…”

Section: Influence Of Fatty Acid Storage and Metabolism In Mdsc And Macrophage Differentiationmentioning

confidence: 99%

Fatty Acid Metabolism in Myeloid-Derived Suppressor Cells and Tumor-Associated Macrophages: Key Factor in Cancer Immune Evasion

Siddiqui

Glauben

2022

Cancers

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The tumor microenvironment (TME) comprises various cell types, soluble factors, viz, metabolites or cytokines, which together play in promoting tumor metastasis. Tumor infiltrating immune cells play an important role against cancer, and metabolic switching in immune cells has been shown to affect activation, differentiation, and polarization from tumor suppressive into immune suppressive phenotypes. Macrophages represent one of the major immune infiltrates into TME. Blood monocyte-derived macrophages and myeloid derived suppressor cells (MDSCs) infiltrating into the TME potentiate hostile tumor progression by polarizing into immunosuppressive tumor-associated macrophages (TAMs). Recent studies in the field of immunometabolism focus on metabolic reprogramming at the TME in polarizing tumor-associated macrophages (TAMs). Lipid droplets (LD), detected in almost every eukaryotic cell type, represent the major source for intra-cellular fatty acids. Previously, LDs were mainly described as storage sites for fatty acids. However, LDs are now recognized to play an integral role in cellular signaling and consequently in inflammation and metabolism-mediated phenotypical changes in immune cells. In recent years, the role of LD dependent metabolism in macrophage functionality and phenotype has been being investigated. In this review article, we discuss fatty acids stored in LDs, their role in modulating metabolism of tumor-infiltrating immune cells and, therefore, in shaping the cancer progression.

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Section: Influence Of Fatty Acid Storage and Metabolism In Mdsc And Macrophage Differentiationmentioning

confidence: 99%

Fatty Acid Metabolism in Myeloid-Derived Suppressor Cells and Tumor-Associated Macrophages: Key Factor in Cancer Immune Evasion

Siddiqui

Glauben

2022

Cancers

View full text Add to dashboard Cite

show abstract

Targeting glutamine metabolism enhances tumor specific immunity by inhibiting the generation of MDSCs and reprogramming tumor associated macrophages

Cited by 1 publication

References 73 publications

Fatty Acid Metabolism in Myeloid-Derived Suppressor Cells and Tumor-Associated Macrophages: Key Factor in Cancer Immune Evasion

Fatty Acid Metabolism in Myeloid-Derived Suppressor Cells and Tumor-Associated Macrophages: Key Factor in Cancer Immune Evasion

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