Targeting genetic tool for long non-coding RNA of cancer stem cells with aptamer-guided nanocarriers

Zaiki, Yazid; Wong, Tin Wui

doi:10.1080/17425247.2021.1989408

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…[111] Based on their effects on tumor microenvironments and metastasis, recent research has examined the feasibility of using aptamer-guided nanocarriers to transport genetic tools that can silence lncRNAs in cancer stem cells. [112] Bi, Zhuofei, et al examined utilizing NPs to deliver siRNA to suppress AFAP1-AS1 in TNBC cells. Encapsulating siRNA with aptamers, which attach to TNBC cell receptors, may improve delivery and therapeutic effectiveness for AFAP1-AS1 silencing.…”

Section: Nanoparticle-mediated Lncrnas-targeting Strategies Against C...mentioning

confidence: 99%

Nanomaterials‐Based Targeting of Long Non‐Coding RNAs in Cancer: A Cutting‐Edge Review of Current Trends

Davodabadi,

Farasati Far,

Sargazi

et al. 2024

ChemMedChem

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This review article spotlights the burgeoning potential of using nanotherapeutic strategies to target long non‐coding RNAs (lncRNAs) in cancer cells. This updated discourse underlines the prominent role of lncRNAs in instigating cancer, facilitating its progression, and metastasis, validating lncRNAs' potential for being effective diagnostic biomarkers and therapeutic targets. The manuscript offers an in‐depth examination of different strategies presently employed to modulate lncRNA expression and function for therapeutic purposes. Among these strategies, Antisense Oligonucleotides (ASOs), RNA interference (RNAi) technologies, and the innovative CRISPR‐based gene editing tools garner noteworthy mention. A significant section of the review is dedicated to nanocarriers and their crucial role in drug delivery. These nanocarriers' efficiency in targeting lncRNAs in varied types of cancers is elaborated upon, validating the importance of targeted therapy. The manuscript culminates by reaffirming the promising prospects of targeting lncRNAs to enhance the accuracy of cancer diagnosis and improve treatment efficacy. Consequently, new paths are opened to more research and innovation in employing nanotherapeutic approaches against lncRNAs in cancer cells. Thus, this comprehensive manuscript serves as a valuable resource that underscores the vital role of lncRNAs and the various nano‐strategies for targeting them in cancer treatment.

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Section: Nanoparticle-mediated Lncrnas-targeting Strategies Against C...mentioning

confidence: 99%

Nanomaterials‐Based Targeting of Long Non‐Coding RNAs in Cancer: A Cutting‐Edge Review of Current Trends

Davodabadi,

Farasati Far,

Sargazi

et al. 2024

ChemMedChem

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“…Chimeric aptamers have also been used to deliver RNAi to lncRNA molecules in vitro via recognition of and interaction with lncRNA regulatory proteins [ 101 ]; however, it appears that the chimeric aptamer approach for lncRNA targeting has not yet been implemented in vivo in the CNS. While design of such aptamers must be carefully planned to ensure correct folding and avoidance of structural perturbations to the lncRNA target upon binding, it will be interesting to monitor the progress of these tools in neurodevelopmental studies, given that the small size (<25 kDa), relatively low production cost, reduced immunogenicity and toxicity, and stability over a variety of pHs [ 102 ] make aptamers a good option for nanoparticle-mediated delivery across the BBB. Indeed, aptamer-drug nanoparticle conjugates, which have gained ground in targeted cancer therapeutics [ 103 ], could pose exciting new options for neurodevelopmental disease therapies.…”

Section: Understanding Techniques To Modify Lncrna Expression In Mode...mentioning

confidence: 99%

Techniques for investigating lncRNA transcript functions in neurodevelopment

Srinivas,

Siqueira,

Guil

2023

Mol Psychiatry

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Long noncoding RNAs (lncRNAs) are sequences of 200 nucleotides or more that are transcribed from a large portion of the mammalian genome. While hypothesized to have a variety of biological roles, many lncRNAs remain largely functionally uncharacterized due to unique challenges associated with their investigation. For example, some lncRNAs overlap with other genomic loci, are expressed in a cell-type-specific manner, and/or are differentially processed at the post-transcriptional level. The mammalian CNS contains a vast diversity of lncRNAs, and lncRNAs are highly abundant in the mammalian brain. However, interrogating lncRNA function in models of the CNS, particularly in vivo, can be complex and challenging. Here we review the breadth of methods used to investigate lncRNAs in the CNS, their merits, and the understanding they can provide with respect to neurodevelopment and pathophysiology. We discuss remaining challenges in the field and provide recommendations to assay lncRNAs based on current methods.

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“…The chemicals and toxins from these wastes pose risks to both wildlife and human populations. Furthermore, micro-and nano-sized waste particles can contaminate the environment, leading to chronic non-communicable diseases like cancer (Zaiki & Wong, 2021). Governance-related shortcomings and inadequacies in waste collection programs, both formal and informal, have negatively impacted numerous efforts, including recycling initiatives, affecting the community and the environment (Gutberlet, 2017).…”

mentioning

confidence: 99%

Architecture as Urban Catalyst: Infographic Design Guideline on Kuala Lumpur Riverfront Revitalisation

Mohd Yusman,

Shaari,

Samadi

et al. 2023

IJSCET

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In various areas, communities and localities worldwide, a traversing river playsa vital role as the lifeblood of many dwellings andurban areas. Kuala Lumpur's expanding urban spaces indicate a thriving economy. Despite this, therapid developmenthas led to the construction ofmanyresidential and commercial buildings along the river, resulting in pollution from domestic, physical, and chemical waste. This pollution poses a threat to urban waste management, impacting both health and the river's ecosystem. To address this issue, this study endeavoursto recommend an updated set of design guidelines for the Dayabumi, Kuala Lumpur riverfront architecture. The recommended guideline will focus onalterations to theriver form and build form interventions to achieve the desired results. Through case studies, literature reviews, and observations from developed countries, the study identified best practices for waste management and architectural design. The findingsencompass waste management programs and design guidelines covering build form, river form, green coverings, economy injection, and the overall urban environment. By enforcing appropriate regulations and preparing for future waste production, we can protect and revitalize the riverfront at Dayabumi, Kuala Lumpur.

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Targeting genetic tool for long non-coding RNA of cancer stem cells with aptamer-guided nanocarriers

Cited by 4 publications

References 18 publications

Nanomaterials‐Based Targeting of Long Non‐Coding RNAs in Cancer: A Cutting‐Edge Review of Current Trends

Nanomaterials‐Based Targeting of Long Non‐Coding RNAs in Cancer: A Cutting‐Edge Review of Current Trends

Techniques for investigating lncRNA transcript functions in neurodevelopment

Architecture as Urban Catalyst: Infographic Design Guideline on Kuala Lumpur Riverfront Revitalisation

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