Targeting foodborne pathogens via surface-functionalized nano-antimicrobials

Bahrami, Arash; Delshadi, Rana; Cacciotti, Ilaria; Esfanjani, Afshin Faridi; Rezaei, Atefe; Tarhan, Özgür; Lee, Chi-Ching; Assadpour, Elham; Tomaş, Merve; Vahapoğlu, Beyza; Güven, Esra; Williams, Leonard; Jafari, Seid Mahdi

doi:10.1016/j.cis.2022.102622

Cited by 18 publications

(4 citation statements)

References 143 publications

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“…Ligand-modified NPs can specifically target to the receptors on bacterial cell envelope for enhanced attachment. [177,196,197] Inspired by the interactions between the proteins on bacterial surface and carbohydrates on mammalian cell surface during pathogenesis of infections, the liposomes modified with maltohexaose (≈150 nm, ≈−27 mV) exhibited targeting ability to bacteria-specific maltodextrin transport protein, thereby enhancing the bacterial cell internalization of antibacterial agents. At 6 h post-injection, the fluorescence intensity of the modified liposomes from bacteria-infected tissue was seven-fold and threefold stronger than that from the lipopolysaccharide-induced inflamed tissue and cancer, respectively.…”

Section: Selecting Excellent Ligandsmentioning

confidence: 99%

Strategies to Promote the Journey of Nanoparticles Against Biofilm‐Associated Infections

Wang,

et al. 2024

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Biofilm‐associated infections are one of the most challenging healthcare threats for humans, accounting for 80% of bacterial infections, leading to persistent and chronic infections. The conventional antibiotics still face their dilemma of poor therapeutic effects due to the high tolerance and resistance led by bacterial biofilm barriers. Nanotechnology‐based antimicrobials, nanoparticles (NPs), are paid attention extensively and considered as promising alternative. This review focuses on the whole journey of NPs against biofilm‐associated infections, and to clarify it clearly, the journey is divided into four processes in sequence as 1) Targeting biofilms, 2) Penetrating biofilm barrier, 3) Attaching to bacterial cells, and 4) Translocating through bacterial cell envelope. Through outlining the compositions and properties of biofilms and bacteria cells, recent advances and present the strategies of each process are comprehensively discussed to combat biofilm‐associated infections, as well as the combined strategies against these infections with drug resistance, aiming to guide the rational design and facilitate wide application of NPs in biofilm‐associated infections.

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Section: Selecting Excellent Ligandsmentioning

confidence: 99%

Strategies to Promote the Journey of Nanoparticles Against Biofilm‐Associated Infections

Wang,

et al. 2024

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“…In the food sector, the application of nanotechnology significantly impacts many areas, such as the production of packaging material, food formulation with enhanced bioavailability, enhancing organoleptic properties, ensuring food safety, and others [ 109 ]. It has also become a leading technology in food preservation, particularly in combating foodborne bacterial growth and biofilm formation [ 110 ].…”

Section: Nanotechnology Approach: An Emerging Antibiofilm Platformmentioning

confidence: 99%

Exploring Possible Ways to Enhance the Potential and Use of Natural Products through Nanotechnology in the Battle against Biofilms of Foodborne Bacterial Pathogens

Kannappan

Prasath²,

Sathya

et al. 2023

Pathogens

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Biofilms enable pathogenic bacteria to survive in unfavorable environments. As biofilm-forming pathogens can cause rapid food spoilage and recurrent infections in humans, especially their presence in the food industry is problematic. Using chemical disinfectants in the food industry to prevent biofilm formation raises serious health concerns. Further, the ability of biofilm-forming bacterial pathogens to tolerate disinfection procedures questions the traditional treatment methods. Thus, there is a dire need for alternative treatment options targeting bacterial pathogens, especially biofilms. As clean-label products without carcinogenic and hazardous potential, natural compounds with growth and biofilm-inhibiting and biofilm-eradicating potentials have gained popularity as natural preservatives in the food industry. However, the use of these natural preservatives in the food industry is restricted by their poor availability, stability during food processing and storage. Also there is a lack of standardization, and unattractive organoleptic qualities. Nanotechnology is one way to get around these limitations and as well as the use of underutilized bioactives. The use of nanotechnology has several advantages including traversing the biofilm matrix, targeted drug delivery, controlled release, and enhanced bioavailability, bioactivity, and stability. The nanoparticles used in fabricating or encapsulating natural products are considered as an appealing antibiofilm strategy since the nanoparticles enhance the activity of the natural products against biofilms of foodborne bacterial pathogens. Hence, this literature review is intended to provide a comprehensive analysis of the current methods in nanotechnology used for natural products delivery (biofabrication, encapsulation, and nanoemulsion) and also discuss the different promising strategies employed in the recent and past to enhance the inhibition and eradication of foodborne bacterial biofilms.

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“…Nanoparticles (NPs) as a means of antimicrobials are seen as an attractive antibiofilm strategy due to the ability to penetrate biofilm matrices, targeted antimicrobial delivery, controlled release, enhanced bioavailability, bioactivity, and stability (Arunachalam et al., 2023; Bahrami et al., 2022; Singh et al., 2023). Encapsulation of antimicrobials within lipid‐, carbohydrate‐, metal‐, and polymer‐based NPs has proved to be a successful strategy in overcoming physiological barriers and exhibiting potent antibiofilm activity (Pang et al., 2022).…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of nisin‐loaded chitosan nanoparticles functionalized with DNase I for the removal of Listeria monocytogenes biofilms

Hu,

Du,

et al. 2024

Journal of Food Science

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Listeria monocytogenes biofilms represent a continuous source of contamination, leading to serious food safety concerns and economic losses. This study aims to develop novel nisin‐loaded chitosan nanoparticles (CSNPs) functionalized with DNase I and evaluate its antibiofilm activity against L. monocytogenes on food contact surfaces. Nisin‐loaded CSNPs (CS‐N) were first prepared by ionic cross‐linking, and DNase I was covalently grafted on the surface (DNase‐CS‐N). The NPs were subsequently characterized by Zetasizer Nano, transmission electron microscopy, Fourier transform infrared (FT‐IR), and X‐ray diffraction (XRD). The antibiofilm activity of NPs was evaluated against L. monocytogenes on polyurethane (PU). The DNase‐CS‐N was fabricated and characterized with quality attributes (particle size—427.0 ± 15.1 nm, polydispersity [PDI]—0.114 ± 0.034, zeta potential—+52.5 ± 0.2 mV, encapsulation efficiency—46.5% ± 3.6%, DNase conjugate rate—70.4% ± 0.2). FT‐IR and XRD verified the loading of nisin and binding of DNase I with chitosan. The DNase‐CS‐N caused a 3 log colony‐forming unit (CFU)/cm2 reduction of L. monocytogenes biofilm cells, significantly higher than those in CSNPs (1.4 log), CS‐N (1.8 log), and CS‐N in combination with DNase I (2.2 log) treatment groups. In conclusion, nisin‐loaded CSNPs functionalized with DNase I were successfully prepared and characterized with smooth surface and nearly spherical shape, high surface positive charge, and good stability, which is effective to eradicate L. monocytogenes biofilm cells on food contact surfaces, exhibiting great potential as antibiofilm agents in food industry.Practical ApplicationListeria monocytogenes biofilms are a common safety hazard in food processing. In this study, novel nanoparticles were successfully constructed and are expected to be a promising antibiofilm agent in the food industry.

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Targeting foodborne pathogens via surface-functionalized nano-antimicrobials

Cited by 18 publications

References 143 publications

Strategies to Promote the Journey of Nanoparticles Against Biofilm‐Associated Infections

Strategies to Promote the Journey of Nanoparticles Against Biofilm‐Associated Infections

Exploring Possible Ways to Enhance the Potential and Use of Natural Products through Nanotechnology in the Battle against Biofilms of Foodborne Bacterial Pathogens

Preparation and characterization of nisin‐loaded chitosan nanoparticles functionalized with DNase I for the removal of Listeria monocytogenes biofilms

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