Targeting Ferroptosis for Lung Diseases: Exploring Novel Strategies in Ferroptosis‐Associated Mechanisms

Ma, Teng; Zhou, Yong; Wang, Ci; Wang, Lu; Chen, Jingxian; Yang, Huihui; Zhang, Chenyu; Guan, Cha‐Xiang

doi:10.1155/2021/1098970

Cited by 25 publications

(18 citation statements)

References 197 publications

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“…Moreover, the Hallmark pathway analysis also revealed that the high-risk group was mainly enriched for epithelial-mesenchymal transition, apical junction, angiogenesis, hedgehog signaling, myogenesis, and mitotic spindle, whereas the low-risk group was mainly enriched for peroxisome, bile acid metabolism, fatty acid metabolism, and oxidative phosphorylation ( Figure 8B ). Of note, peroxisomes, fatty acid metabolism, and oxidative phosphorylation enriched in the low-risk group were associated with ferroptosis, which have been reported to be closely linked to ferroptosis ( Stockwell et al, 2017 ; Tang and Kroemer, 2020 ; Ma et al, 2021 ).…”

Section: Resultsmentioning

confidence: 89%

“…Therefore, early diagnosis is essential for improving the prognosis of CC patients. However, the survival of CC patients is poor because of the complexity of the disease, late disease detection, and lack of reliable risk-assessment biomarkers (Lin et al, 2020;Yang C. et al, 2021). Even after treatment, the risk of recurrence and metastasis in CC patients is still high (Chang et al, 2020;Jin et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Even after treatment, the risk of recurrence and metastasis in CC patients is still high (Chang et al, 2020;Jin et al, 2020). In recent years, more studies have suggested that it is promising to solve the problem by integrating computational techniques with big biomedical data involving multiple types of biomarkers including epigenetic, genetic, and gene expression profiles (Yang Y. et al, 2021;. Therefore, identifying effective biomarkers to establish a prognostic model for survival prediction is gaining increasing attention.…”

Section: Introductionmentioning

confidence: 99%

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A Prognostic Ferroptosis-Related lncRNA Model Associated With Immune Infiltration in Colon Cancer

Tan²,

Yu³

2022

Front. Genet.

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Colon cancer (CC) is a common malignant tumor worldwide, and ferroptosis plays a vital role in the pathology and progression of CC. Effective prognostic tools are required to guide clinical decision-making in CC. In our study, gene expression and clinical data of CC were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We identified the differentially expressed ferroptosis-related lncRNAs using the differential expression and gene co-expression analysis. Then, univariate and multivariate Cox regression analyses were used to identify the effective ferroptosis-related lncRNAs for constructing the prognostic model for CC. Gene set enrichment analysis (GSEA) was conducted to explore the functional enrichment analysis. CIBERSORT and single-sample GSEA were performed to investigate the association between our model and the immune microenvironment. Finally, three ferroptosis-related lncRNAs (XXbac-B476C20.9, TP73-AS1, and SNHG15) were identified to construct the prognostic model. The results of the validation showed that our model was effective in predicting the prognosis of CC patients, which also was an independent prognostic factor for CC. The GSEA analysis showed that several ferroptosis-related pathways were significantly enriched in the low-risk group. Immune infiltration analysis suggested that the level of immune cell infiltration was significantly higher in the high-risk group than that in the low-risk group. In summary, we established a prognostic model based on the ferroptosis-related lncRNAs, which could provide clinical guidance for future laboratory and clinical research on CC.

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Section: Resultsmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Prognostic Ferroptosis-Related lncRNA Model Associated With Immune Infiltration in Colon Cancer

Tan²,

Yu³

2022

Front. Genet.

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“…The mechanism behind such an effect is largely unknown. It is hypothesized that lymphoid-specific helicase (LSH), a DNA methylation modifier stabilizing the transcripts that enhances tumourigenesis in NSCLC [ 116 ], reduces CS-induced ferroptosis by interacting with stearoyl-coa desaturase-1 (SCD-1), which is an iron-containing microsomal enzyme which exists in the endoplasmic reticulum responsible for the degradation of saturated fatty acid into monounsaturated fatty acid [ 117 ]. The reduction of SCD-1 expression inhibits proliferation and induces apoptosis in NSCLC cells through reducing α7nAChR-mediated Akt phosphorylation [ 118 ].…”

Section: Potential Role Of Dietary Antioxidants Against Cigarette Smo...mentioning

confidence: 99%

Dietary Antioxidants and Lung Cancer Risk in Smokers and Non-Smokers

Alsharairi

2022

Healthcare

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Smoking is considered a major risk factor in the development of lung diseases worldwide. Active smoking and secondhand (passive) smoke (SHS) are related to lung cancer (LC) risk. Oxidative stress (OS) and/or lipid peroxidation (LP) induced by cigarette smoke (CS) are found to be involved in the pathogenesis of LC. Meta-analyses and other case-control/prospective cohort studies are inconclusive and have yielded inconsistent results concerning the protective role of dietary vitamins C and E, retinol, and iron intake against LC risk in smokers and/or non-smokers. Furthermore, the role of vitamins and minerals as antioxidants with the potential in protecting LC cells against CS-induced OS in smokers and non-smokers has not been fully elucidated. Thus, this review aims to summarize the available evidence reporting the relationships between dietary antioxidant intake and LC risk in smokers and non-smokers that may be used to provide suggestions for future research.

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“…Ferroptosis after being first reported by Dixon et al, in 2012 has been recognized as a potential therapeutic target in many diseases (Hassannia et al, 2019;Qiu et al, 2020;Ma et al, 2021). Ferroptosis was a unique intracellular iron-dependent form of non-apoptotic cell death that occurred through excessive peroxidation of polyunsaturated fatty acids (Dixon et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Ferroptosis-related genes are involved in asthma and regulate the immune microenvironment

Wang

Jia²,

Gu³

et al. 2023

Front. Pharmacol.

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Background: Asthma was a chronic inflammatory illness driven by complicated genetic regulation and environmental exposure. The complex pathophysiology of asthma has not been fully understood. Ferroptosis was involved in inflammation and infection. However, the effect of ferroptosis on asthma was still unclear. The study was designed to identify ferroptosis-related genes in asthma, providing potential therapeutic targets.Methods: We conducted a comprehensive analysis combined with WGCNA, PPI, GO, KEGG, and CIBERSORT methods to identify ferroptosis-related genes that were associated with asthma and regulated the immune microenvironment in GSE147878 from the GEO. The results of this study were validated in GSE143303 and GSE27066, and the hub genes related to ferroptosis were further verified by immunofluorescence and RT-qPCR in the OVA asthma model.Results: 60 asthmatics and 13 healthy controls were extracted for WGCNA. We found that genes in the black module (r = −0.47, p < 0.05) and magenta module (r = 0.51, p < 0.05) were associated with asthma. CAMKK2 and CISD1 were discovered to be ferroptosis-related hub genes in the black and magenta module, separately. We found that CAMKK2 and CISD1 were mainly involved in the CAMKK-AMPK signaling cascade, the adipocytokine signaling pathway, the metal cluster binding, iron-sulfur cluster binding, and 2 iron, 2 sulfur cluster binding in the enrichment analysis, which was strongly correlated with the development of ferroptosis. We found more infiltration of M2 macrophages and less Tregs infiltration in the asthma group compared to healthy controls. In addition, the expression levels of CISD1 and Tregs were negatively correlated. Through validation, we found that CAMKK2 and CISD1 expression were upregulated in the asthma group compared to the control group and would inhibit the occurrence of ferroptosis.Conclusion: CAMKK2 and CISD1 might inhibit ferroptosis and specifically regulate asthma. Moreover, CISD1 might be tied to the immunological microenvironment. Our results could be useful to provide potential immunotherapy targets and prognostic markers for asthma.

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Targeting Ferroptosis for Lung Diseases: Exploring Novel Strategies in Ferroptosis‐Associated Mechanisms

Cited by 25 publications

References 197 publications

A Prognostic Ferroptosis-Related lncRNA Model Associated With Immune Infiltration in Colon Cancer

A Prognostic Ferroptosis-Related lncRNA Model Associated With Immune Infiltration in Colon Cancer

Dietary Antioxidants and Lung Cancer Risk in Smokers and Non-Smokers

Ferroptosis-related genes are involved in asthma and regulate the immune microenvironment

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