Targeting epigenome with dietary nutrients in cancer: Current advances and future challenges

Khan, Mohammad Imran; Rath, Suvasmita; Adhami, Vaqar M.; Mukhtar, Hasan

doi:10.1016/j.phrs.2017.12.008

Cited by 22 publications

(19 citation statements)

References 188 publications

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“…These results highlight its potential preventive properties for breast cancer (Schnekenburger and Diederich 2015). SNF represents one example of bioactive molecules from Li et al (2016aLi et al ( , 2016b and Khan et al (2018) Rosmarinic acid Fig. 3.…”

Section: Phytochemicals Modulating the Epigenetic Alterations Of Dna mentioning

confidence: 79%

“…Flavonoids are the most representative group of dietary polyphenols with diverse biological activities including anti-bacterial, anti-viral, analgesic, hepatoprotective, apoptotic, and estrogenic functions (Kumar and Pandey 2013). The chemoprevention activity of flavonoids might be mediated by certain epigenetic mechanisms, including modulation of DNA methylation status and histone methylation and acetylation (Jiang et al 2015;Guo et al 2018;Khan et al 2018). The flavone apigenin can restore the silenced status of Nrf2 gene in skin epidermal cells by reducing the expression of three DNA methyl transferase proteins (DNMT1, DNMT3A, and DNMT3B) as well as the expression of some HDACs (Shukla and Gupta 2010).…”

Section: Phytochemicals Modulating the Epigenetic Alterations Of Dna mentioning

confidence: 99%

“…The major catechin from green tea, EGCG, exerts its chemoprevention effect by blocking cell proliferation and transformation and promoting apoptosis and cell cycle arrest in several human cancer cell lines including leukemia, melanoma, breast cancer, lung, and colon (Singh et al 2011;Schramm 2013). The molecular mechanism underlying EGCG chemoprevention action is related with the regulation of several signal transduction pathways including: MAPK, PI3K/AKT, Wnt, Notch, and NF-jB (Pandey et al 2010;Moseley et al 2013;Schramm 2013;Khan et al 2018). Additionally, EGCG has been demonstrated to induce the increase of tumor suppressor expression, such as: p53, p21, p16 and Rb with certain roles in chemoprevention (Pandey et al 2010;Du et al 2012).…”

Section: Phytochemicals Modulating the Epigenetic Alterations Of Dna mentioning

confidence: 99%

“…There has been an increased interest in SFN recently, due to its potency to influence epigenetic processes through targeting key epigenetic modulators such as DNA methyltransferases and HDACs, which may lead to local or global alterations of epigenetic hallmarks resulting in subsequent gene transcription and expression level changes (Khan et al 2018). Also, SFN modulates DNA demethylation by downregulation of the expression of DNMT1 and DNMT3B, subsequently leading to induced demethylation of cyclin D2 gene promoter and expression in cancer cells (Hsu et al 2011).…”

Section: Phytochemicals Modulating the Epigenetic Alterations Of Dna mentioning

confidence: 99%

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Phytochemicals in cancer prevention: modulating epigenetic alterations of DNA methylation

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et al. 2019

Phytochem Rev

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Cancer can take many years to develop from initiation to progression. The long period of development might represent an opportunity to use multi-functional, multi-targeted preventive drugs to block or reverse tumorigenesis. One path to cancer prevention could be to target and reverse the early epigenetic alterations. Unlike genetic mutations, they are potentially reversible and can be restored to their normal state. Epidemiological studies have revealed the close link between rich diets in bioactive compounds and the low incidence of different types of cancer. Thus, the study regarding the impact of bioactive nutrients on the epigenome has become widespread, with focus on the modulation of epigenetic mechanisms of gene expression, such as genomic DNA methylation. Following altered activity and expression of DNA methyl transferases and ten-eleven translocation enzymes, different types of cancers exert local DNA hypermethylation of gene promoters of tumor suppressor genes or of non-coding RNAs (microRNAs and long-noncoding RNAs), as well as global hypomethylation. Recently, the potential of phytochemicals to modulate epigenetic events in human health has become evident, although specific molecular mechanisms are still unclear. Phytochemicals and other bioactive dietary compounds can restore global and gene-specific promoter DNA methylation patterns by reactivating DNA methyltransferases or by providing the provision of methyl groups. Several natural products, such as EGCG, curcumin, sulforaphane, have shown DNMT inhibitory activity, but this property needs more in-depth investigations. This review focuses on the impact of modified DNA methylation pattern on early carcinogenesis and summarizes the effects/mechanism of phytochemical interventions on this type of epigenetic alterations.

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Section: Phytochemicals Modulating the Epigenetic Alterations Of Dna mentioning

confidence: 79%

Section: Phytochemicals Modulating the Epigenetic Alterations Of Dna mentioning

confidence: 99%

Section: Phytochemicals Modulating the Epigenetic Alterations Of Dna mentioning

confidence: 99%

Section: Phytochemicals Modulating the Epigenetic Alterations Of Dna mentioning

confidence: 99%

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Phytochemicals in cancer prevention: modulating epigenetic alterations of DNA methylation

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Enciu

Tarcomnicu³

et al. 2019

Phytochem Rev

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“…Various doses of these nutrients were reported in in vitro studies. Additional preclinical and clinical data are needed for clinical application of these nutrients (KHAN, et al 2018).…”

Section: Epigenetics and Dietmentioning

confidence: 99%

Epigenetics in disease etiopathogenesis

Glavaški

Stankov

2019

Genetika

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2019): Epigenetics in disease etiopathogenesis.-Genetika, Vol 51, No.3, 975-994. The term epigenetics refers to heritable changes in gene expression that are not caused by modifications in DNA sequence. Epigenetic changes are DNA methylation, histone modifications, nucleosome positioning, and non-coding RNA (including microRNA) mediated modifications. Epigenetic mechanisms are involved in malignant diseases, imprinting defects, and some hereditary diseases. Recent research explained the role of epigenetic disorders in infections, autoimmune, neurodegenerative and bone diseases, as well as in psoriasis, endometriosis, and polycystic ovary syndrome. Epigenetic modifications have a potential clinical application as diagnostic and prognostic biomarkers, and also as therapeutic targets in oncology, endocrinology, cardiology, and neuropsychiatry. Stress, anxiety, depression, emotions and many other psychological factors may affect epigenetic mechanisms. Influence of preconception parental stress exposure transmits to the next generation through epigenetic changes, as direct results of prenatal and postnatal environmental factors. Epigenetic changes identify environmental factors which affect health and cause disease onset. Milk is the sophisticated system of communication between mother and infant, operating via epigenetic mechanisms. Lifelong consumption of bovine milk causes epigenetic disorders. Recent studies provide important information about the role of bioactive dietary nutrients which modify DE SARIO, A. (2009): Clinical and molecular overview of inherited disorders resulting from epigenomic dysregulation. Eur. J. Med. Genet., 52(6): 363-372.

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Biological Dogmas in Relation to the Origin of Evolutionary Novelties

Tatemoto

Guerrero-Bosagna

2018

Origin and Evolution of Biodiversity

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Targeting epigenome with dietary nutrients in cancer: Current advances and future challenges

Cited by 22 publications

References 188 publications

Phytochemicals in cancer prevention: modulating epigenetic alterations of DNA methylation

Phytochemicals in cancer prevention: modulating epigenetic alterations of DNA methylation

Epigenetics in disease etiopathogenesis

Biological Dogmas in Relation to the Origin of Evolutionary Novelties

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