Targeting epigenetics and lncRNAs in liver disease: From mechanisms to therapeutics

Peng, Xiaofei; Huang, Shifeng; Chen, Lingjuan; Xu, Lili; Ye, Wen-Chu

doi:10.1016/j.phrs.2021.105846

Cited by 9 publications

(6 citation statements)

References 285 publications

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“…Lipid accumulation is a critical step for lipid-laden foam cells formation, and a characteristic of atherosclerotic lesions throughout all stages of lipid-related diseases, such as fatty liver disease, obesity, myocardial infarction (MI), and atherosclerosis ( 11 , 12 ). Our findings illustrated that the lncRNA H19 overexpression elevated lipid accumulation and its knockdown lowered lipid accumulation in THP-1-derived macrophages treated with ox-LDL, implying that lncRNA is important for lipid accumulation.…”

Section: Discussionmentioning

confidence: 99%

“…Long non-coding RNAs (lncRNAs), which are non-proteincoding transcripts surpassing 200 nucleotides in length, have a vital function in regulating gene expression (7,8). Aberrant expression of lncRNA is strongly correlated with lipid accumulation and atherosclerosis (9)(10)(11)(12). LncRNA H19, located on chromosome 11p15.5 in humans, is a canonical paternally imprinted and maternally expressed gene (13).…”

Section: Introductionmentioning

confidence: 99%

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The Pathogenic Role of Long Non-coding RNA H19 in Atherosclerosis via the miR-146a-5p/ANGPTL4 Pathway

Huang

Zhao

Peng

et al. 2021

Front. Cardiovasc. Med.

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The abnormally expressed long non-coding RNA (lncRNA) H19 has a crucial function in the development and progression of cardiovascular disease; however, its role in atherosclerosis is yet to be known. We aimed to examine the impacts of lncRNA H19 on atherogenesis as well as the involved mechanism. The outcomes from this research illustrated that the expression of lncRNA H19 was elevated in mouse blood and aorta with lipid-loaded macrophages and atherosclerosis. Adeno-associated virus (AAV)-mediated lncRNA H19 overexpression significantly increased the atherosclerotic plaque area in apoE−/− mice supplied with a Western diet. The upregulation of lncRNA H19 decreased the miR-146a-5p expression but increased the levels of ANGPTL4 in mouse blood and aorta and THP-1 cells. Furthermore, lncRNA H19 overexpression promoted lipid accumulation in oxidized low-density lipoprotein (ox-LDL)-induced THP-1 macrophages. However, the knockdown of lncRNA H19 served as a protection against atherosclerosis in apoE−/− mice and lowered the accumulation of lipids in ox-LDL-induced THP-1 macrophages. lncRNA H19 promoted the expression of ANGPTL4 via competitively binding to miR-146a-5p, thus promoting lipid accumulation in atherosclerosis. These findings altogether demonstrated that lncRNA H19 facilitated the accumulation of lipid in macrophages and aggravated the progression of atherosclerosis through the miR-146a-5p/ANGPTL4 pathway. Targeting lncRNA H19 might be an auspicious therapeutic approach for preventing and treating atherosclerotic disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Pathogenic Role of Long Non-coding RNA H19 in Atherosclerosis via the miR-146a-5p/ANGPTL4 Pathway

Huang

Zhao

Peng

et al. 2021

Front. Cardiovasc. Med.

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“…The N-term tails of histone core proteins are enriched with arginine and lysine residues and undergo covalent post-transcriptional modifications. This structure of chromatin together with histone modifications determines the ability of interaction between DNA and transcription factors [ 23 ]. Depending on the histone type, amino acid residue and chemical functional group (methyl group (methylation), acetyl group (acetylation), phosphate group (phosphorylation), ubiquitin (ubiquitinylation), SUMO (sumoylation), hydrophobic isoprene polymers (isoprenylation), glycosyl group (glycosylation), etc.)…”

Section: Histone Modifications and Ncrnas: The Theorymentioning

confidence: 99%

“…As a result, the bonds between DNA and histones are weakened following chromatin decondensation and transcription activation [ 193 ]. Histone proteins have structural and functional roles almost in all nuclear processes, and its aberrations are associated with such diseases as tumors, liver injury, viral hepatitis and Alzheimer’s disease [ 23 , 194 ].…”

Section: Histone Modifications and Ncrnas: The Theorymentioning

confidence: 99%

“…They are over 200 nucleotides in length, located in the nucleus or cytoplasm, rarely encode proteins, are less conservative among species and usually demonstrate cell- and tissue-specific expression patterns. A number of studies confirmed the important role of lncRNAs in the regulation of transcription, translation, splicing, cell growth and differentiation, apoptosis, cell cycle, dosage compensation, imprinting, pluripotency and control of chromatin structure and modifications [ 1 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Histone Modifications and Non-Coding RNAs: Mutual Epigenetic Regulation and Role in Pathogenesis

Bure

Немцова

Кузнецова

2022

IJMS

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In the last few years, more and more scientists have suggested and confirmed that epigenetic regulators are tightly connected and form a comprehensive network of regulatory pathways and feedback loops. This is particularly interesting for a better understanding of processes that occur in the development and progression of various diseases. Appearing on the preclinical stages of diseases, epigenetic aberrations may be prominent biomarkers. Being dynamic and reversible, epigenetic modifications could become targets for a novel option for therapy. Therefore, in this review, we are focusing on histone modifications and ncRNAs, their mutual regulation, role in cellular processes and potential clinical application.

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Modulating the Expression of Exercise-induced lncRNAs: Implications for Cardiovascular Disease Progression

Yu,

Zhang

2024

J. of Cardiovasc. Trans. Res.

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Targeting epigenetics and lncRNAs in liver disease: From mechanisms to therapeutics

Cited by 9 publications

References 285 publications

The Pathogenic Role of Long Non-coding RNA H19 in Atherosclerosis via the miR-146a-5p/ANGPTL4 Pathway

The Pathogenic Role of Long Non-coding RNA H19 in Atherosclerosis via the miR-146a-5p/ANGPTL4 Pathway

Histone Modifications and Non-Coding RNAs: Mutual Epigenetic Regulation and Role in Pathogenesis

Modulating the Expression of Exercise-induced lncRNAs: Implications for Cardiovascular Disease Progression

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