Targeting EGFR and HER2 for Molecular Imaging of Cancer

Gong, Haibiao; Sampath, Lakshmi; Kovar, Joy L.; Olive, D. Mike

doi:10.5772/30717

Cited by 5 publications

(4 citation statements)

References 103 publications

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“…18 A toxicity study on IRDye 800CW revealed no observed adverse effects at a dose approximately 10 000 times higher than the projected dose for in vivo imaging. This was the first toxicity study of an NIR dye capable of bioconjugation.…”

Section: Discussionmentioning

confidence: 95%

“…17 A variety of EGFR-binding molecules (including EGF, antibodies, antibody fragments, affibodies, nanobodies and tyrosine kinase inhibitor derivatives) have been employed as tumor imaging agents. 18 In contrast, examples of EGFRvIIItargeted molecular imaging are lacking. In this study, the EGFRspecific affibody (monomeric), panitumumab, and EGF were labeled with IRDye 800CW.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A comparative study of affibody, panitumumab, and EGF for near-infrared fluorescence imaging of EGFR- and EGFRvIII-expressing tumors

Gong

Kovar

Cheung

et al. 2013

Cancer Biology & Therapy

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

A comparative study of affibody, panitumumab, and EGF for near-infrared fluorescence imaging of EGFR- and EGFRvIII-expressing tumors

Gong

Kovar

Cheung

et al. 2013

Cancer Biology & Therapy

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“…Zhao et al [ 130 ] conjugated EGFR-targeting affibody to Ac-Cys label and Alexa680 (Cys-ZEGFR:1907). Affibodies have also been labeled with a fluorine-18 probe and to an iron oxide nanoparticle for PET, optical, and MRI imaging [ 131 , 132 , 133 , 134 , 135 ].…”

Section: Targeting Egfr and Vegfr For Molecular Imagingmentioning

confidence: 99%

Molecular Targeting of Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor Receptor (VEGFR)

et al. 2021

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Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) are two extensively studied membrane-bound receptor tyrosine kinase proteins that are frequently overexpressed in many cancers. As a result, these receptor families constitute attractive targets for imaging and therapeutic applications in the detection and treatment of cancer. This review explores the dynamic structure and structure-function relationships of these two growth factor receptors and their significance as it relates to theranostics of cancer, followed by some of the common inhibition modalities frequently employed to target EGFR and VEGFR, such as tyrosine kinase inhibitors (TKIs), antibodies, nanobodies, and peptides. A summary of the recent advances in molecular imaging techniques, including positron emission tomography (PET), single-photon emission computerized tomography (SPECT), computed tomography (CT), magnetic resonance imaging (MRI), and optical imaging (OI), and in particular, near-IR fluorescence imaging using tetrapyrrolic-based fluorophores, concludes this review.

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“…Recently, Zagoruiko’s group developed a more detailed naphtha reforming kinetic model and elegantly reduced the kinetic parameters of 488 reactions to 39 . Peng and Gomez-Prado proposed a molecular type and homologous series method (MTHS), which characterized the molecular composition of fractions with petroleum molecular type and carbon number information. , Recently, Gong utilized the MTHS method to model the kinetics of diesel hydrotreating and accurately calculated the product yield in an industrial plant . Zhang’s group proposed a structural unit and bond-electron matrix (SU-BEM) framework for modeling the molecular composition of petroleum fractions. , On this basis, Chen et al developed a kinetic model for catalytic oil slurry hydrotreating involving 3827 molecules and 7572 reactions and predicted the key product molecules and reaction temperatures in the reactor .…”

Section: Introductionmentioning

confidence: 99%

Molecular-Level Catalytic Reforming Kinetic Model Based on Modified Structure-Oriented Lumping

Jiang,

Cai,

et al. 2024

Ind. Eng. Chem. Res.

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A kinetic model for the catalytic reforming process was developed at the molecular level. The structure-oriented lumping (SOL) method was modified to fit catalytic reforming, and a structural increment was created to distinguish between the xylene isomers; the xylene isomers are important reforming products. To model the governing chemistry, a reaction network involving 140 molecules and 697 reactions was generated in terms of 16 reaction rules. Then, a mathematical model of the naphtha reforming process was developed and included a reaction kinetic model and a reformer reactor model. The linear free energy relation (LFER) method was used to reduce the kinetic parameters. Experiments under different conditions were conducted to optimize the parameters. The results showed that the calculated values of the product yield and molecular composition were in good agreement with the experimental data. The conversion of hydrocarbon molecules was revealed by calculating the distribution of the molecules in the reactor. Sensitivity analysis was performed to investigate the effect of the reaction temperature on the molecular transformations.

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Targeting EGFR and HER2 for Molecular Imaging of Cancer

Cited by 5 publications

References 103 publications

A comparative study of affibody, panitumumab, and EGF for near-infrared fluorescence imaging of EGFR- and EGFRvIII-expressing tumors

A comparative study of affibody, panitumumab, and EGF for near-infrared fluorescence imaging of EGFR- and EGFRvIII-expressing tumors

Molecular Targeting of Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor Receptor (VEGFR)

Molecular-Level Catalytic Reforming Kinetic Model Based on Modified Structure-Oriented Lumping

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