Targeting dysregulated intracellular immunometabolism within synovial microenvironment in rheumatoid arthritis with natural products
Shengtao Hu,
Ye Lin,
Yuanyuan Tang
et al.
Abstract:Immunometabolism has been an emerging hotspot in the fields of tumors, obesity, and atherosclerosis in recent decades, yet few studies have investigated its connection with rheumatoid arthritis (RA). In principle, intracellular metabolic pathways upstream regulated by nutrients and growth factors control the effector functions of immune cells. Dynamic communication and hypermetabolic lesions of immune cells within the inflammatory synovial microenvironment contributes to the development and progression of RA. … Show more
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