Targeting DSS-induced ulcerative colitis: evaluating the therapeutic potential of WPI–stachyose conjugates

Abstract

The pursuit for food-based alternatives to conventional therapies for ulcerative colitis (UC) demands immediate attention. In prior investigations, we synthesized WPI-stachyose conjugates through the Maillard reaction, identifying them as functional...

Stachyose Exerts Anticolitis Efficacy by Re-balancing Treg/Th17 and Activating the Butyrate-Derived PPARγ Signaling Pathway

“…He et al demonstrated that oral administration of STA at a dose of 1,500 mg/kg body weight modulates gut microbiota and alleviates DSS-induced acute colitis in mice . Furthermore, Wang et al confirmed that the amelioration of colitis symptoms by STA at a dose of 1,000 mg/kg body weight was closely associated with the restoration of gut microbiota and metabolites . Currently, further investigation is necessary to explore the impact of dosage and purity on the efficacy of STA in UC therapy as well as to find causal evidence between therapy and gut microbiota.…”

“…24 Furthermore, Wang et al confirmed that the amelioration of colitis symptoms by STA at a dose of 1,000 mg/kg body weight was closely associated with the restoration of gut microbiota and metabolites. 25 Currently, further investigation is necessary to explore the impact of dosage and purity on the efficacy of STA in UC therapy as well as to find causal evidence between therapy and gut microbiota. In this study, three different concentrations of STA (200, 400, and 600 mg/kg body weight) were utilized to demonstrate a dose-dependent alleviation of colitis symptoms (Figure 2).…”