Targeting drug delivery and efficient lysosomal escape for chemo-photodynamic cancer therapy by a peptide/DNA nanocomplex

Wang, Qiusheng; He, Ziyun; Zhu, Hai; Gao, Wenxia; Zhang, Nan; Li, Jing; Yan, Jianqin; He, Bin; Ye, Xueting

doi:10.1039/d1tb02441h

Cited by 23 publications

(12 citation statements)

References 54 publications

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“…Aptamer AS1411 is a guanine-rich oligonucleotide containing 26 bases, it forms stable G-quadruplex dimers and binds with highly expressed nucleolin on the cytomembrane of tumor cells with high affinity and specificity to interfere DNA replication through nucleolin shuttle, thus to inhibit cell proliferation [ 55 ]. The tumor targeting of AS1411 was investigated.…”

Section: Resultsmentioning

confidence: 99%

Gold nanorods/tetrahedral DNA composites for chemo-photothermal therapy

Wang

Zhang

et al. 2022

Regenerative Biomaterials

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Combination therapy is extensively developed for cancer treatment in recent years due to its high efficiency. Herein, we constructed a nanocomposite based on gold nanorods (GNRs) and drug-loaded tetrahedral DNA nanostructures (TDN) for chemo-photothermal combinational therapy. Anti-tumor drug doxorubicin (DOX) was loaded via the insertion within GC base pairs of TDN. The aptamer AS1411 was attached to the apex of TDN (ATDN) to target tumor cells. The DOX-loaded DNA tetrahedron (ATDN-DOX) was compressed by the GNRs coated with PEI (GNRs@ATDN-DOX) to realize the photothermal function and lysosome escape. GNRs under the illumination of 808 nm infrared laser showed high photothermal conversion and stability due to the protection of PEI layer. The drug-loading capacity of ATDN-DOX was as high as 314 DOX molecules in per ATDN. The positive charge of PEI in GNRs@ATDN-DOX nanocomposites was utilized to achieve excellent cell penetration and induce proton sponge effect for lysosomal escape. The nanocomposites presented HeLa and 4T1 cells targeting and resulted in efficient anticancer activity.

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Section: Resultsmentioning

confidence: 99%

Gold nanorods/tetrahedral DNA composites for chemo-photothermal therapy

Wang

Zhang

et al. 2022

Regenerative Biomaterials

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“…AS1411, an aptamer conjugated with nucleolin overexpressed on the surface of cancer cells, was attached to tFNA at one vertex, and was reported to improve the efficiency of cellular endocytosis to deliver therapeutic and imaged tFNA. 58 , 59 , 106 – 109 Similarly, Ma et al adopted an anti-HER2 aptamer carried by tFNAs to target HER2-positive breast cancer cells. These HER2-tFNA complexes mediated the breast carcinoma cell apoptosis and inhibited their growth.…”

Section: Tfnasmentioning

confidence: 99%

“…DOX@tFNA complexes have been shown to effectively enter cells via endocytosis, overcome multidrug resistance, and induce cancer cell apoptosis. 109 , 128 In addition to DOX, other anti-cancer drugs (PTX, 85 platinum, 133 and camptothecin 134 ) can also be encapsulated using tFNAs via intercalation within the DNA double-stranded helix. Traditional Chinese medicine monomers are not widely applied in clinics due to their poor aqueous solubility, low stability, and inadequate cellular and tissue penetration.…”

Section: Tfnasmentioning

confidence: 99%

Advances in regenerative medicine applications of tetrahedral framework nucleic acid-based nanomaterials: an expert consensus recommendation

Lin

Wang

et al. 2022

Int J Oral Sci

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With the emergence of DNA nanotechnology in the 1980s, self-assembled DNA nanostructures have attracted considerable attention worldwide due to their inherent biocompatibility, unsurpassed programmability, and versatile functions. Especially promising nanostructures are tetrahedral framework nucleic acids (tFNAs), first proposed by Turberfield with the use of a one-step annealing approach. Benefiting from their various merits, such as simple synthesis, high reproducibility, structural stability, cellular internalization, tissue permeability, and editable functionality, tFNAs have been widely applied in the biomedical field as three-dimensional DNA nanomaterials. Surprisingly, tFNAs exhibit positive effects on cellular biological behaviors and tissue regeneration, which may be used to treat inflammatory and degenerative diseases. According to their intended application and carrying capacity, tFNAs could carry functional nucleic acids or therapeutic molecules through extended sequences, sticky-end hybridization, intercalation, and encapsulation based on the Watson and Crick principle. Additionally, dynamic tFNAs also have potential applications in controlled and targeted therapies. This review summarized the latest progress in pure/modified/dynamic tFNAs and demonstrated their regenerative medicine applications. These applications include promoting the regeneration of the bone, cartilage, nerve, skin, vasculature, or muscle and treating diseases such as bone defects, neurological disorders, joint-related inflammatory diseases, periodontitis, and immune diseases.

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“…DNA is a flexible and programmable nanomaterial [ 140 ]. A multifunctional up-conversion nanoplatform (UCNP-ApDz-TMPyP 4 ) was designed for combining PDT with gene therapy, whereby an aptamer-DNAzyme (ApDz) was adsorbed via electrostatic interactions [ 141 ].…”

Section: Biomolecule-mimetic Nanomaterials For Ptt and Pdt Applicationsmentioning

confidence: 99%

Biomolecule-mimetic nanomaterials for photothermal and photodynamic therapy of cancers: Bridging nanobiotechnology and biomedicine

Yang

Zhu

et al. 2022

J Nanobiotechnol

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Nanomaterial-based phototherapy has become an important research direction for cancer therapy, but it still to face some obstacles, such as the toxic side effects and low target specificity. The biomimetic synthesis of nanomaterials using biomolecules is a potential strategy to improve photothermal therapy (PTT) and photodynamic therapy (PDT) techniques due to their endowed biocompatibility, degradability, low toxicity, and specific targeting. This review presents recent advances in the biomolecule-mimetic synthesis of functional nanomaterials for PTT and PDT of cancers. First, we introduce four biomimetic synthesis methods via some case studies and discuss the advantages of each method. Then, we introduce the synthesis of nanomaterials using some biomolecules such as DNA, RNA, protein, peptide, polydopamine, and others, and discuss in detail how to regulate the structure and functions of the obtained biomimetic nanomaterials. Finally, potential applications of biomimetic nanomaterials for both PTT and PDT of cancers are demonstrated and discussed. We believe that this work is valuable for readers to understand the mechanisms of biomimetic synthesis and nanomaterial-based phototherapy techniques, and will contribute to bridging nanotechnology and biomedicine to realize novel highly effective cancer therapies.

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Targeting drug delivery and efficient lysosomal escape for chemo-photodynamic cancer therapy by a peptide/DNA nanocomplex

Abstract: A peptide/DNA nanocomplex was developed to targeted delivering chemotherapeutics and photosensitizer to cancer cells for efficient combination therapy. Chemotherapeutic drug doxorubicin (DOX) and photosensitizer 5, 10, 15, 20-tetra (1-methylpyridine-4-yl) porphyrin...

Cited by 23 publications

References 54 publications

Gold nanorods/tetrahedral DNA composites for chemo-photothermal therapy

Gold nanorods/tetrahedral DNA composites for chemo-photothermal therapy

Advances in regenerative medicine applications of tetrahedral framework nucleic acid-based nanomaterials: an expert consensus recommendation

Biomolecule-mimetic nanomaterials for photothermal and photodynamic therapy of cancers: Bridging nanobiotechnology and biomedicine

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