Targeting DNA Methylation in the Adult Brain through Diet

Allison, Joseph; Kaliszewska, Aleksandra; Uceda, Sara; Reiriz, Manuel; Arias, Natalia

doi:10.3390/nu13113979

Cited by 27 publications

(13 citation statements)

References 257 publications

(288 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, growing efforts are being placed to influence in the epigenetic mechanisms involved in the development of different psychiatric disorders, including MDD ( 15 , 16 ). Diet is a promising modulator of several epigenetic mechanisms in the entire organism, also in the brain, where it modulates the expression of several genes involved in the function of this organ ( 17 – 19 ). The patient with depression is frequently co-affected by malnutrition.…”

Section: Introductionmentioning

confidence: 99%

Nutrition, Epigenetics, and Major Depressive Disorder: Understanding the Connection

et al. 2022

View full text Add to dashboard Cite

Major depressive disorder (MDD) is a complex, multifactorial disorder of rising prevalence and incidence worldwide. Nearly, 280 million of people suffer from this leading cause of disability in the world. Moreover, patients with this condition are frequently co-affected by essential nutrient deficiency. The typical scene with stress and hustle in developed countries tends to be accompanied by eating disorders implying overnutrition from high-carbohydrates and high-fat diets with low micronutrients intake. In fact, currently, coronavirus disease 2019 (COVID-19) pandemic has drawn more attention to this underdiagnosed condition, besides the importance of the nutritional status in shaping immunomodulation, in which minerals, vitamins, or omega 3 polyunsaturated fatty acids (ω-3 PUFA) play an important role. The awareness of nutritional assessment is greater and greater in the patients with depression since antidepressant treatments have such a significant probability of failing. As diet is considered a crucial environmental factor, underlying epigenetic mechanisms that experience an adaptation or consequence on their signaling and expression mechanisms are reviewed. In this study, we included metabolic changes derived from an impairment in cellular processes due to lacking some essential nutrients in diet and therefore in the organism. Finally, aspects related to nutritional interventions and recommendations are also addressed.

show abstract

Section: Introductionmentioning

confidence: 99%

Nutrition, Epigenetics, and Major Depressive Disorder: Understanding the Connection

et al. 2022

View full text Add to dashboard Cite

show abstract

“…[20][21][22] Initial data suggest that they may provide useful biomarkers at the interface between the environment and aging biology. 41 However, little is known about how these measures relate to cognitive aging and dementia or the extent to which they are shaped by environmental exposures, such as diet. Our findings, showing associations of the DunedinPACE epigenetic clock with dietary exposure and dementia, suggest that this DNAm measure can provide a tool to better understand how environmental factors, such as diet, may contribute to brain aging.…”

Section: Discussionmentioning

confidence: 99%

“…DNA methylation clocks that aim to measure processes of biological aging have emerged as novel measures of risk for aging‐related diseases, including dementia 20–22 . Initial data suggest that they may provide useful biomarkers at the interface between the environment and aging biology 41 . However, little is known about how these measures relate to cognitive aging and dementia or the extent to which they are shaped by environmental exposures, such as diet.…”

Section: Discussionmentioning

confidence: 99%

Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study

Thomas,

Ryan,

Caspi

et al. 2024

Annals of Neurology

View full text Add to dashboard Cite

ObjectivePeople who eat healthier diets are less likely to develop dementia, but the biological mechanism of this protection is not well understood. We tested the hypothesis that healthy diet protects against dementia because it slows the pace of biological aging.MethodsWe analyzed Framingham Offspring Cohort data. We included participants ≥60 years‐old, free of dementia and having dietary, epigenetic, and follow‐up data. We assessed healthy diet as long‐term adherence to the Mediterranean‐Dash Intervention for Neurodegenerative Delay diet (MIND, over 4 visits spanning 1991–2008). We measured the pace of aging from blood DNA methylation data collected in 2005–2008 using the DunedinPACE epigenetic clock. Incident dementia and mortality were defined using study records compiled from 2005 to 2008 visit through 2018.ResultsOf n = 1,644 included participants (mean age 69.6, 54% female), n = 140 developed dementia and n = 471 died over 14 years of follow‐up. Greater MIND score was associated with slower DunedinPACE and reduced risks for dementia and mortality. Slower DunedinPACE was associated with reduced risks for dementia and mortality. In mediation analysis, slower DunedinPACE accounted for 27% of the diet‐dementia association and 57% of the diet‐mortality association.InterpretationFindings suggest that slower pace of aging mediates part of the relationship of healthy diet with reduced dementia risk. Monitoring pace of aging may inform dementia prevention. However, a large fraction of the diet‐dementia association remains unexplained and may reflect direct connections between diet and brain aging that do not overlap other organ systems. Investigation of brain‐specific mechanisms in well‐designed mediation studies is warranted. ANN NEUROL 2024

show abstract

“…Evidence continues to demonstrate that the gut microbiota is particularly implicated in brain physiology and behavior, affecting host mental health [ 16 , 17 , 18 ]. New advances on the techniques for its analyses have allowed for knowing deeply the gut microbiome on different human conditions (age- or healthy-related) [ 19 , 20 , 21 ]; however, a “gold standard” reference of a human gut microbiota composition is not yet known. What is known is that the imbalance of the gut microbiota composition or functions can affect physiological homeostasis and alter the signals from the gut to brain, negatively influencing brain health or vice versa [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

The Therapeutic Role of Exercise and Probiotics in Stressful Brain Conditions

Martínez-Guardado

Arboleya

Grijota

et al. 2022

IJMS

Self Cite

View full text Add to dashboard Cite

Oxidative stress has been recognized as a contributing factor in aging and in the progression of multiple neurological disorders such as Parkinson’s disease, Alzheimer’s dementia, ischemic stroke, and head and spinal cord injury. The increased production of reactive oxygen species (ROS) has been associated with mitochondrial dysfunction, altered metal homeostasis, and compromised brain antioxidant defence. All these changes have been reported to directly affect synaptic activity and neurotransmission in neurons, leading to cognitive dysfunction. In this context two non-invasive strategies could be employed in an attempt to improve the aforementioned stressful brain status. In this regard, it has been shown that exercise could increase the resistance against oxidative stress, thus providing enhanced neuroprotection. Indeed, there is evidence suggesting that regular physical exercise diminishes BBB permeability as it reinforces antioxidative capacity, reduces oxidative stress, and has anti-inflammatory effects. However, the differential effects of different types of exercise (aerobic exhausted exercise, anaerobic exercise, or the combination of both types) and the duration of physical activity will be also addressed in this review as likely determinants of therapeutic efficacy. The second proposed strategy is related to the use of probiotics, which can also reduce some biomarkers of oxidative stress and inflammatory cytokines, although their underlying mechanisms of action remain unclear. Moreover, various probiotics produce neuroactive molecules that directly or indirectly impact signalling in the brain. In this review, we will discuss how physical activity can be incorporated as a component of therapeutic strategies in oxidative stress-based neurological disorders along with the augmentation of probiotics intake.

show abstract

Targeting DNA Methylation in the Adult Brain through Diet

Cited by 27 publications

References 257 publications

Nutrition, Epigenetics, and Major Depressive Disorder: Understanding the Connection

Nutrition, Epigenetics, and Major Depressive Disorder: Understanding the Connection

Diet, Pace of Biological Aging, and Risk of Dementia in the Framingham Heart Study

The Therapeutic Role of Exercise and Probiotics in Stressful Brain Conditions

Contact Info

Product

Resources

About