Targeting delivery of synergistic dual drugs with elastic PEG-modified multi-functional nanoparticles for hepatocellular carcinoma therapy

Gao, Xiujun; Zhang, Jiawei; He, Zhuanxia; Chang, Luchen; Jian, Zhihan; Liu, Liyan; Liu, Ying; Hu, Chunhong; Wei, Xi

doi:10.1016/j.ijpharm.2022.121567

Cited by 8 publications

(3 citation statements)

References 33 publications

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“…Both C/DCNB+US and C/DCNB groups show statistically significant differences from the control group, and the results indicate that C/DCNB had good anti-tumor ability. The significant statistical difference between C/DNB and C/DCNB further demonstrate that the surface modified PEG of C/DCNB reduced the clearance ability of reticuloendothelial system (RES) 31 and enhanced drug accumulation in tumors. A significant statistical difference between C/DCNB+US and C/DCNB further confirmed that ultrasound stimulation effectively enhances the anti-tumor capability of C/DCNB.…”

Section: Resultsmentioning

confidence: 91%

Dual-Drug Loaded Nanobubbles Combined with Sonodynamic and Chemotherapy for Hepatocellular Carcinoma Therapy

Guo,

Wang,

Chen

et al. 2024

IJN

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Purpose Chemotherapy remains the primary therapeutic approach for advanced Hepatocellular Carcinoma (HCC). The therapeutic effect of chemotherapy is limited and the toxic side effects are serious. The aim of this study is to develop a nanobubble that is ultrasonically responsive to reduce the toxic side effects of direct chemotherapy. Methods We developed curcumin/doxorubicin-cis-aconitic anhydride-polyethylene glycol nanobubble (C/DCNB) surface modified with acid-sensitive polyethylene glycol (PEG). And it is loaded with curcumin (CUR) and doxorubicin (DOX), as liposomes at the nanoscale for diagnosis and therapy of tumors. Results In this study, the acid-sensitive PEG on the surface layer of nanobubbles serves to stabilize them in the blood circulatory system and in normal tissues, while peeling off in the acidic tumor microenvironment (pH 6.8). C/DCNB can identify tumor sites through contrast-enhanced ultrasound (CEUS). And ultrasound-mediated nanobubbles promote permeability of the tumor vascular, thus improving the enhanced permeability and retention (EPR) effects in the tumor, leading to the accumulation of nanobubbles in the tumor. After endocytosis of nanobubbles, drugs are released and curcumin generates reactive oxygen species (ROS) under ultrasound conditions. CUR can enhance the sensitivity of tumor cells to DOX by inhibiting the expression of P-glycoprotein. In vitro and vivo experiments demonstrate that C/DCNB can facilitate contrast-enhanced ultrasound imaging while simultaneously delivering drugs, enabling both imaging and treatment. Conclusion The combination of C/DCNB and ultrasound provides an effective strategy for improving the efficiency of HCC therapy and imaging.

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Section: Resultsmentioning

confidence: 91%

Dual-Drug Loaded Nanobubbles Combined with Sonodynamic and Chemotherapy for Hepatocellular Carcinoma Therapy

Guo,

Wang,

Chen

et al. 2024

IJN

Self Cite

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“…pH-sensitive nanostructures can be employed for co-delivery of sorafenib and Tim3-siRNA to provide gene-/chemo-therapy [95] . Increased blood circulation time and promoted retention at tumor tissue are other benefits of using nanoparticles in HCC therapy [96] . Moreover, ferroptosis and apoptosis can be induced upon using nanostructures in HCC therapy [94] .…”

Section: Hepatocellular Carcinoma: An Overviewmentioning

confidence: 99%

Multifunctional and stimuli-responsive liposomes in hepatocellular carcinoma diagnosis and therapy

Samaei,

Daryab,

Gholami

et al. 2024

Translational Oncology

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“…Hepatocellular carcinoma is the most prevalent of primary tumors and a common malignant tumor ( 1 ), which greatly threatens human health. With the development of a therapeutic strategy, the current therapy of primary hepatocellular tumor mainly depends on the comprehensiveness of treatment ( 2 , 3 ), which includes surgery, interventional therapy, targeted therapy, and immune therapy ( 4 ). A gallium-based alloy is an admixture with liquid status under room temperature and is high profile in biomedical engineering fields due to its excellent properties encompassing bio-compatibility, controllability ( 5 , 6 ), high conductivity, and good thermal conductivity ( 7 , 8 ).…”

Section: Introductionmentioning

confidence: 99%

Liquid metal injected from interstitial channels for inhibiting subcutaneous hepatoma growth and improving MRI/MAT image contrast

Yang

Xia

et al. 2022

Front. Oncol.

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ObjectiveLiquid metal (LM) nowadays is considered a new biomedical material for medical treatment. The most common application of LM in medical therapy is taking LM as a carrier for oncology therapeutics. However, the feasibility and direct effect of LM in tumor treatment are still unknown, and how to delineate the negative resection margin (NRM) of the tumor is also a crucial problem in surgery. We aimed to inject LM into interstitial channels of extremities of mice to overlay the surface of the primary tumor to investigate the effect of LM on inhibiting tumor growth and highlight the NRM of the tumor.MethodsIn this study, all 50 BALB/c-nude female mice were used to construct the transplanted HepG2-type hepatocellular carcinoma model. One week after the establishment of the model, the mice were divided into three groups, named LM group, PBS group and Control group by injecting different liquid materials into the forelimb interstitial channel of the mice. T2WI image on MRI and Magneto-acoustic tomography (MAT) were used to show the distribution of LM and PBS in vivo. The group comparisons of tumor growth and blood tests were evaluated by one-way ANOVA and post-hoc analysis. And the biocompatibility of LM to BALB/c nude mice was evaluated by histopathological analysis of LM group and control group.ResultsThe volume change ratio of tumor was significantly lower in LM group than in PBS and Control group after 10 days of grouping. Compared with PBS and Control group, the main indexes of blood tests in LM group were significantly lower and close to normal level. In addition, the distribution of LM in vivo could be clearly observed under T2WI anatomic images and the crossprofile of the tumor in MAT. LM also has a obvious contrast in MRI T2WI and enhanced the amplitude of imaging signal in MAT.ConclusionLM may inhibit the growth of transplanted hepatoma tumor through tumor encapsulation. In vivo, tumor imaging and LM distribution imaging were achieved by MRI T2WI, which verified that LM injected with interstitial injection made the NRM of tumor more prominent and had the potential of being MRI contrast agent. At the same time, LM could also be a new conductive medium to improve the imaging quality of MAT. Moreover, LM performed mild biocompatibility.

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Targeting delivery of synergistic dual drugs with elastic PEG-modified multi-functional nanoparticles for hepatocellular carcinoma therapy

Cited by 8 publications

References 33 publications

Dual-Drug Loaded Nanobubbles Combined with Sonodynamic and Chemotherapy for Hepatocellular Carcinoma Therapy

Dual-Drug Loaded Nanobubbles Combined with Sonodynamic and Chemotherapy for Hepatocellular Carcinoma Therapy

Multifunctional and stimuli-responsive liposomes in hepatocellular carcinoma diagnosis and therapy

Liquid metal injected from interstitial channels for inhibiting subcutaneous hepatoma growth and improving MRI/MAT image contrast

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