2024
DOI: 10.1186/s12935-023-03206-z
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Targeting cholesterol impairs cell invasion of all breast cancer types

Mauriane Maja,
Marie Verfaillie,
Patrick Van Der Smissen
et al.

Abstract: Background Breast cancer clinical outcome relies on its intrinsic molecular subtype and mortality is almost exclusively due to metastasis, whose mechanism remains unclear. We recently revealed the specific contribution of plasma membrane cholesterol to the invasion of malignant MCF10CAIa but not premalignant MCF10AT and normal MCF10A cell lines in 2D, through invadopodia formation and extracellular matrix (ECM) degradation. In the present study, we address the impact of breast cancer subtypes, … Show more

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