Targeting Cellular Signaling Pathways in Breast Cancer Stem Cells and its Implication for Cancer Treatment

Pires, Bruno R. B.; Amorim, Ísis Salviano Soares de; Souza, Layane Duarte e; Rodrigues, Juliana Alves; Mencalha, André Luiz

doi:10.21873/anticanres.11151

Cited by 49 publications

(54 citation statements)

References 101 publications

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“…57 Suppression of GSK3b (a negative regulator of the Wnt pathway) was sufficient to diminish the stem cell features of breast cancer cells. 58 Wnt/b-catenin signaling also contributes to EMT and metastasis in breast cancer. Deyet al found that the patients identified by the Wnt/ b-catenin classifier had a greater risk of lung metastasis in TNBC.…”

Section: Wnt/b-catenin Signaling Pathwaymentioning

confidence: 99%

“…It is noted that concomitant dysregulation of Hh, Notch, and Wnt signaling pathways has been observed in cancer, suggesting their potential cooperation in promoting tumor development and metastasis. 58,[91][92][93][94] Co-activation of both Hh and Wnt pathways in clinical TNBC samples is associated with shorter recurrence-free and overall survival. 93 Consistent with this finding, nuclear b-catenin has been shown to increase Gli1 transcriptional activity in other cancer types.…”

Section: Hedgehog Signaling Pathwaymentioning

confidence: 99%

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Breast cancer lung metastasis: Molecular biology and therapeutic implications

Jin

Han

Siegel

et al. 2018

Cancer Biology & Therapy

207

164

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Distant metastasis accounts for the vast majority of deaths in patients with cancer. Breast cancer exhibits a distinct metastatic pattern commonly involving bone, liver, lung, and brain. Breast cancer can be divided into different subtypes based on gene expression profiles, and different breast cancer subtypes show preference to distinct organ sites of metastasis. Luminal breast tumors tend to metastasize to bone while basal-like breast cancer (BLBC) displays a lung tropism of metastasis. However, the mechanisms underlying this organ-specific pattern of metastasis still remain to be elucidated. In this review, we will summarize the recent advances regarding the molecular signaling pathways as well as the therapeutic strategies for treating breast cancer lung metastasis.

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Section: Wnt/b-catenin Signaling Pathwaymentioning

confidence: 99%

Section: Hedgehog Signaling Pathwaymentioning

confidence: 99%

Breast cancer lung metastasis: Molecular biology and therapeutic implications

Jin

Han

Siegel

et al. 2018

Cancer Biology & Therapy

207

164

View full text Add to dashboard Cite

show abstract

“…This is driven by the activation of the epithelia-to-mesenchymal transition (EMT) program, strongly involved in the dissemination of car-cinoma cells to distant tissues, through the deregulation of signaling pathways as Wnt/β-catenin, and conferred to CSC resistance to therapeutic agents [86, 87]. BC stem cells (BCSC), represent a small population of cells within the tumor mass exhibiting stem cell-like characteristics and have emerged as being responsible for tumor development, recurrence and MBC [88]. At the molecular level, these cells are characterized by the CD44+/CD24− phenotype and by the activation of signaling pathways, particularly those linked to the stem cell phenotype, such as nuclear factor-kappa beta (NF-κB), signal transducer and activator of transcription 3 (STAT3), Wnt/β catenin, Hedgehog, and NOTCH.…”

Section: Cancer Stem Cells and Therapeutic Implicationsmentioning

confidence: 99%

“…Indeed, the LGK974, a porcupine inhibitor, which blocks Wnt palmitoylation [93], and PRI-724, CAMP responsive element binding protein(CREB)/catenin antagonist [94], have shown interesting results and are in phase I trial for breast cancer and other solid tumors. Some other inhibitors targeting NOTCH, NF-κB, STAT3 have shown their anti-tumor activity in vitro and in vivo models [88]. Clinical trials with inhibitors are only in their early stages.…”

Section: Cancer Stem Cells and Therapeutic Implicationsmentioning

confidence: 99%

Precision medicine in breast cancer: reality or utopia?

et al. 2017

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Many cancers, including breast cancer, have demonstrated prognosis and support advantages thanks to the discovery of targeted therapies. The advent of these new approaches marked the rise of precision medicine, which leads to improve the diagnosis, prognosis and treatment of cancer. Precision medicine takes into account the molecular and biological specificities of the patient and their tumors that will influence the treatment determined by physicians. This new era of medicine is accessible through molecular genetics platforms, the development of high-speed sequencers and means of analysis of these data. Despite the spectacular results in the treatment of cancers including breast cancer, described in this review, not all patients however can benefit from this new strategy. This seems to be related to the many genetic mutations, which may be different from one patient to another or within the same patient. It comes to give new impetus to the research—both from a technological and biological point of view—to make the hope of precision medicine accessible to all.

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“…Several signaling pathways are involved in generation and maintenance of CSCs, including the embryonic signaling cascades NOTCH, Wnt and Hh as well as the interleukin-6 (IL-6)-JAK/STAT cascade and the mTOR pathway (for detailed pathway descriptions see[5,83,84]). Of note, these embryonic signaling pathways are also involved in basic cholangiocyte differentiation[85].…”

Section: Relevance Of Stemness Pathways In Biliary Tract Cancer Stem mentioning

confidence: 99%

Biliary tract cancer stem cells - translational options and challenges

Mayr

Ocker

Ritter

et al. 2017

WJG

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Management of biliary tract cancer remains challenging. Tumors show high recurrence rates and therapeutic resistance, leading to dismal prognosis and short survival. The cancer stem cell model states that a tumor is a heterogeneous conglomerate of cells, in which a certain subpopulation of cells - the cancer stem cells - possesses stem cell properties. Cancer stem cells have high clinical relevance due to their potential contributions to development, progression and aggressiveness as well as recurrence and metastasis of malignant tumors. Consequently, reliable identification of as well as pharmacological intervention with cancer stem cells is an intensively investigated and promising research field. The involvement of cancer stem cells in biliary tract cancer is likely as a number of studies demonstrated their existence and the obvious clinical relevance of several established cancer stem cell markers in biliary tract cancer models and tissues. In the present article, we review and discuss the currently available literature addressing the role of putative cancer stem cells in biliary tract cancer as well as the connection between known contributors of biliary tract tumorigenesis such as oncogenic signaling pathways, micro-RNAs and the tumor microenvironment with cancer stem cells.

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Targeting Cellular Signaling Pathways in Breast Cancer Stem Cells and its Implication for Cancer Treatment

Cited by 49 publications

References 101 publications

Breast cancer lung metastasis: Molecular biology and therapeutic implications

Breast cancer lung metastasis: Molecular biology and therapeutic implications

Precision medicine in breast cancer: reality or utopia?

Biliary tract cancer stem cells - translational options and challenges

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