Targeting cellular metabolism in head and neck cancer precision medicine era: A promising strategy to overcome therapy resistance

Lin, Xiaohu; Zhou, Wenkai; Liu, Zheqi; Cao, Wei; Lin, Chengzhong

doi:10.1111/odi.14411

Cited by 6 publications

(3 citation statements)

References 203 publications

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“…However, if the formation of distant metastasis occurs, it is also associated with a very poor prognosis [10][11][12]. Several pathways have been suggested to be involved in acquired and intrinsic resistance development, dissemination, and recurrence of HNSCC and have been recently reviewed in [2,13,14]. Here, we highlight the current knowledge of the process of epithelial-mesenchymal transition (EMT) in HNSCC.…”

Section: Introductionmentioning

confidence: 99%

Transcription Factors and Markers Related to Epithelial–Mesenchymal Transition and Their Role in Resistance to Therapies in Head and Neck Cancers

Pawlicka,

Gumbarewicz,

Błaszczak

et al. 2024

Cancers

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Head and neck cancers (HNCs) are heterogeneous and aggressive tumors of the upper aerodigestive tract. Although various histological types exist, the most common is squamous cell carcinoma (HNSCC). The incidence of HNSCC is increasing, making it an important public health concern. Tumor resistance to contemporary treatments, namely, chemo- and radiotherapy, and the recurrence of the primary tumor after its surgical removal cause huge problems for patients. Despite recent improvements in these treatments, the 5-year survival rate is still relatively low. HNSCCs may develop local lymph node metastases and, in the most advanced cases, also distant metastases. A key process associated with tumor progression and metastasis is epithelial–mesenchymal transition (EMT), when poorly motile epithelial tumor cells acquire motile mesenchymal characteristics. These transition cells can invade different adjacent tissues and finally form metastases. EMT is governed by various transcription factors, including the best-characterized TWIST1 and TWIST2, SNAIL, SLUG, ZEB1, and ZEB2. Here, we highlight the current knowledge of the process of EMT in HNSCC and present the main protein markers associated with it. This review focuses on the transcription factors related to EMT and emphasizes their role in the resistance of HNSCC to current chemo- and radiotherapies. Understanding the role of EMT and the precise molecular mechanisms involved in this process may help with the development of novel anti-cancer therapies for this type of tumor.

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Section: Introductionmentioning

confidence: 99%

Transcription Factors and Markers Related to Epithelial–Mesenchymal Transition and Their Role in Resistance to Therapies in Head and Neck Cancers

Pawlicka,

Gumbarewicz,

Błaszczak

et al. 2024

Cancers

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“…Although the early stage of SCC predisposes better than the advanced stage, there is still a mortality rate of 13% to 30%. The diagnosis appears to be closely related to perineural distance from SCC ("negative perineural invasion") [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Precision Medicine in Oral Health and Diseases: A Systematic Review

Malcangi

Patano

Guglielmo

et al. 2023

JPM

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Precision medicine (PM) is personalized medicine that can develop targeted medical therapies for the individual patient, in which “omics” sciences lead to an integration of data that leads to highly predictive models of the functioning of the individual biological system. They enable rapid diagnosis, assessment of disease dynamics, identification of targeted treatment protocols, and reduction of costs and psychological stress. “Precision dentistry” (DP) is one promising application that need further investigation; the purpose of this paper is therefore to give physicians an overview of the knowledge they need to enhance treatment planning and patient response to therapy. A systematic literature review was conducted on the PubMed, Scopus, and Web of Science databases by analyzing the articles examining the role of precision medicine in dentistry. PM aims to shed light on cancer prevention strategies, by identifying risk factors, and on malformations such as orofacial cleft. Another application is pain management by repurposing drugs created for other diseases to target biochemical mechanisms. The significant heritability of traits regulating bacterial colonization and local inflammatory responses is another result of genomic research, and is useful for DP in the field of caries and periodontitis. This approach may also be useful in the field of orthodontics and regenerative dentistry. The possibility of creating an international network of databases will lead to the diagnosis, prediction, and prevention of disease outbreaks, providing significant economic savings for the world’s health care systems.

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“…Moreover, high glycolytic activity measured based on 18F-FDG positron-emission tomography was a negative prognostic factor for HNSCC patients [10]. Thus, metabolic pathways are now considered potential targets of HNSCC therapy [11,12].…”

Section: Introductionmentioning

confidence: 99%

PRI-724 and IWP-O1 Wnt Signaling Pathway Inhibitors Modulate the Expression of Glycolytic Enzymes in Tongue Cancer Cell Lines

Kleszcz,

Paluszczak,

Belka

et al. 2023

CIMB

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The dysregulation of energetic metabolism is one of the hallmarks of cancer cells. Indeed, the growth of head and neck squamous cell carcinoma (HNSCC) cells depends heavily on glycolytic activity, which can be considered a potential therapeutic target. Wnt signaling is one of the pathways that undergoes upregulation in HNSCC. Our previous studies have shown that Wnt signaling inhibitors—PRI-724 and IWP-O1—attenuate tongue SCC survival and reduce glucose uptake and lactate release. The aim of this research was to further evaluate the possible mechanisms of the previously observed effects. We assessed the effect of PRI-724 and IWP-O1 on the expression of selected glycolytic enzymes: phosphofructokinase M, pyruvate kinase M2, and lactate dehydrogenase. Relative transcript expression was assessed by real-time PCR, and protein levels by Western blot. Moreover, clinical data concerning mRNA and protein expression, gene promoter methylation, and HNSCC patients’ survival time were analyzed by the UALCAN tool, and protein–protein interaction was assessed using the STRING database. Experimental and bioinformatic data confirmed the relation between Wnt signaling and glycolytic enzymes in tongue cancer cells and HNSCC clinical samples. Overall, the inhibition of glucose metabolism by Wnt signaling inhibitors is a promising mode of action against tongue cancer cells.

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Targeting cellular metabolism in head and neck cancer precision medicine era: A promising strategy to overcome therapy resistance

Cited by 6 publications

References 203 publications

Transcription Factors and Markers Related to Epithelial–Mesenchymal Transition and Their Role in Resistance to Therapies in Head and Neck Cancers

Transcription Factors and Markers Related to Epithelial–Mesenchymal Transition and Their Role in Resistance to Therapies in Head and Neck Cancers

Precision Medicine in Oral Health and Diseases: A Systematic Review

PRI-724 and IWP-O1 Wnt Signaling Pathway Inhibitors Modulate the Expression of Glycolytic Enzymes in Tongue Cancer Cell Lines

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