2023
DOI: 10.1038/s41698-023-00407-7
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Targeting CDK1 in cancer: mechanisms and implications

Abstract: Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as promising candidate targets for cancer treatment. These proteins complexed with cyclins play a critical role in cell cycle progression. Most CDKs demonstrate substantially higher expression in cancer tissues compared with normal tissues and, according to the TCGA database, correlate with survival rate in multiple cancer types. Deregulation of CDK1 has been shown to be closely associated with tumorigenesis. CDK1 activation plays a… Show more

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Cited by 35 publications
(21 citation statements)
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References 329 publications
(211 reference statements)
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“…Both DLT and RBV were found to be the frontier candidates based on their binding scores, especially towards the CDK1 target receptor (PDB ID:5HQ0); therefore, they were selected for further investigation. CDK1 is an integral and indispensable protein for cell cycle progression (Saito et al., 2016; Wang et al., 2023).…”
Section: Resultsmentioning
confidence: 99%
“…Both DLT and RBV were found to be the frontier candidates based on their binding scores, especially towards the CDK1 target receptor (PDB ID:5HQ0); therefore, they were selected for further investigation. CDK1 is an integral and indispensable protein for cell cycle progression (Saito et al., 2016; Wang et al., 2023).…”
Section: Resultsmentioning
confidence: 99%
“…CDK1 is unique among these CDKs as it plays a pivotal role in cell cycle progression by promoting G2/M phase transition and G1/S phase transition, and also G1 progression. Inhibition of CDK1 expression and activation effectively suppresses the function of many cancer cells [29]. The six conserved proteins (MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7) form a hexameric complex as a DNA helicase, playing a crucial role in the initiation of DNA replication.…”
Section: Discussionmentioning
confidence: 99%
“…CDK 4/6 inhibitors within the CDK4 (INK4)-retinoblastoma (Rb) pathway govern the regulatory phases of the cell cycle, specifically orchestrating progression from G1 (pre-DNA synthesis) to S (DNA synthesis) ( Hamilton and Infante, 2016 ). CDK 4/6 assumes a pivotal role in overseeing the transition from G1 to S through its interaction with D-type cyclins, thereby inducing the phosphorylation of Rb ( Wang et al, 2023 ). Elevated cyclin-dependent kinase 4/6 activity ensues from mutations in CDK 4/6, the depletion of CDK regulators, and the heightened expression of D-type cycling—all converging to instigate the proliferation of cancer cells.…”
Section: Discussionmentioning
confidence: 99%