Targeting CD56 with an antibody–drug conjugate in Merkel cell carcinoma

Abstract

AD more than 11-fold. 1 From a clinical point of view, this is highly important: AD is not just a skin disease but has been shown to be a systemic disease associating with several comorbidities besides other atopic diseases already in children and adolescents. 5,6 As the risk for comorbidities increases with disease severity, it is important to recognize the individuals at highest risk as early as possible. 7 Perhaps in the next decade we will even have the possibility to prevent these comorbidities by treating moderate-to-severe AD with new treatment modalities or by focusing on factors that increase the risk of AD. Nakamura and coworkers found that polysensitization and lack of breastfeeding were specific risk factors for persistent AD. A previous birth cohort study has also shown that early childhood factors can have a protective effect against allergic sensitization that persists into adulthood. 8 Nevertheless, more longitudinal studies are needed to find the factors that are most useful in AD prevention.