Targeting CD44 receptor-positive lung tumors using polysaccharide-based nanocarriers: Influence of nanoparticle size and administration route

Jeannot, Victor; Mazzaferro, Silvia; Lavaud, J.; Vanwonterghem, Laetitia; Henry, Maxime; Arboléas, Mélanie; Vollaire, Julien; Josserand, Véronique; Coll, Jean‐Luc; Lecommandoux, Sébastien; Schatz, Christophe; Hurbin, Amandine

doi:10.1016/j.nano.2015.11.018

Cited by 53 publications

(57 citation statements)

References 33 publications

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“…[11][12][13] In this context, we previously developed glycopolypeptide-based nanocarriers [14][15][16] that combined the natural polysaccharide hyaluronan, known for its relative affinity toward CD44 receptors that are up-regulated on some cancer cells and involved in tumor growth, progression and metastasis, and poly( -benzyl-L-glutamate) (PBLG), a biodegradable polypeptide characterized by an ordered secondary structure (α-helix). [17,18] These nanoparticles (NP) showed active targeting of CD44-overexpressing lung tumor cells in vitro and in vivo, [19] suggesting that they could be used as a targeted drug-delivery system.…”

Section: Introductionmentioning

confidence: 99%

Anti-tumor efficacy of hyaluronan-based nanoparticles for the co-delivery of drugs in lung cancer

Jeannot

Gauche

Mazzaferro

et al. 2018

Journal of Controlled Release

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Combinations of therapeutic agents could synergistically enhance the response of lung cancer cells. Co-delivery systems capable of transporting chemotherapeutics with different physicochemical properties and with the simultaneous release of drugs remain elusive. Here, we assess the ability of nanoparticles of 30-nm diameter obtained from the self-assembly of hyaluronan-based copolymer targeting CD44 receptors to encapsulate both gefitinib and vorinostat for effective combinational lung cancer treatment. Drug loading was performed by nanoprecipitation. Drug release experiments showed a slow release of both drugs after 5 days. Using two- and three-dimensional lung adenocarcinoma cell cultures, we observed that the nanoparticles were mostly found at the periphery of the CD44-expressing spheroids. These drug-loaded nanoparticles were as cytotoxic as free drugs in the two- and three-dimensional systems and toxicity was due to apoptosis induction. In mouse models, intravenous injection of hyaluronan-based nanoparticles showed a selective delivery to subcutaneous CD44-overexpressing tumors, despite a significant liver capture. In addition, the systemic toxicity of the free drugs was reduced by their co-delivery using the nanoparticles. Finally, intrapulmonary administration of drug-loaded nanoparticles, to avoid a possible hepatic toxicity due to their accumulation in the liver, showed a stronger inhibition of orthotopic lung tumor growth compared to free drugs. In conclusion, hyaluronan-based nanoparticles provide active targeting partially mediated by CD44, less-toxic drug release and improved antitumor efficiency.

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Section: Introductionmentioning

confidence: 99%

Anti-tumor efficacy of hyaluronan-based nanoparticles for the co-delivery of drugs in lung cancer

Jeannot

Gauche

Mazzaferro

et al. 2018

Journal of Controlled Release

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“…Also, the particle comprise of single crystal due to the close comparison between XRD results and TEM micrographs. Based on many studies, nanoparticles size of 25-50 nm is the optimum range to avoid RES sequestering and to have a superior cellular uptake [40][41][42][43][44]. Here, the size obtained demonstrated that the nanoparticles size is in this ideal range and has a potential for effective drug and gene transportation.…”

Section: Resultsmentioning

confidence: 73%

Synthesis of Superparamagnetic Hydroxyapatite Core-Shell Nanostructure by a Rapid Sol-Gel Route

Yusoff

Salimi

Jamlos

2017

e-J. Surf. Sci. Nanotech.

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Magnetic transportation of therapeutic agents to the infected site in the body promises a superb platform for cancer treatment. To increase the safety profile and to stay clear from the agglomeration issue, core shell structure of magnetite-hydroxyapatite (Fe3O4-HAp) nanoparticles was developed. Fe3O4 as the core was synthesised by coprecipitation method which then coated with HAp layer through the sol-gel technique to maintain its high crystalline property. Optimum process parameters were applied during the fabrication process to yield small nanocomposites. The results show that HAp retained its phase purity and molecular structure even with the addition of Fe3O4 as analysed by XRD and FTIR. The FESEM and TEM micrographs show a magnificent monodispersed distribution of functionalised Fe3O4-HAp nanoparticles with the size of around 36 nm. EDXRF result confirmed the Ca/P ratio of 1.63, close to the value of main inorganic material of human bones (HAp) and possessed the superparamagnetic properties with saturation magnetisation of 23.274 emu/g as displayed by VSM curves. Thus, the dual affinity of the magnetic Fe3O4 and excellent biocompatibility HAp offer a synergetic effect as the drug or gene delivery vehicle to stealthy localize in infection site.

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“…In order for the nanoparticle to exhibit selectivity for the lung, it is necessary to obtain small nanoparticles, smaller than 10 nm, and the composition of the nanoparticle also becomes important to obtain stable nanosystems that do not present toxicity when administered in the body (33)(34) .…”

Section: Resultsmentioning

confidence: 99%

Nanoparticles in the Use of Natural Products for the Treatment of Lung Cancer

et al. 2019

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Objetivo: Realizar un estudio bibliográfico sobre el uso de nanopartículas en el transporte de productos naturales para el tratamiento del cáncer de pulmón. Métodos: Se realizó una revisión bibliográfica utilizando los descriptores “Nanoparticles”, “Biological Products” y “Lung Neoplasms”, a través de las bases de datos ScienceDirect, PubMed y SciELO, en el período comprendido entre 2009 y 2018. Resultados: Después del análisis de los artículos de acuerdo con los criterios de inclusión, obtuvimos 31 artículos, de los cuales 25.81% hacían referencia a productos naturales en el tratamiento del cáncer de pulmón, el 29.03% a nanopartículas en el tratamiento del cáncer de pulmón y un 45.16 % a nanopartículas como agentes transportadores de productos naturales para el tratamiento del cáncer de pulmón. Conclusión: El uso de nanopartículas permite el transporte de productos naturales, aumentando sus propiedades terapéuticas contra las células de cáncer de pulmón, además de disminuir los efectos secundarios de estos agentes altamente tóxicos.

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Targeting CD44 receptor-positive lung tumors using polysaccharide-based nanocarriers: Influence of nanoparticle size and administration route

Cited by 53 publications

References 33 publications

Anti-tumor efficacy of hyaluronan-based nanoparticles for the co-delivery of drugs in lung cancer

Anti-tumor efficacy of hyaluronan-based nanoparticles for the co-delivery of drugs in lung cancer

Synthesis of Superparamagnetic Hydroxyapatite Core-Shell Nanostructure by a Rapid Sol-Gel Route

Nanoparticles in the Use of Natural Products for the Treatment of Lung Cancer

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