Targeting cancer through recently developed purine clubbed heterocyclic scaffolds: An overview

Copper Catalyzed Three-Component Ullmann C–S Coupling in PEG for the Synthesis of 6-Aryl/alkylthio-purines

“…Purine ring, well-known as the core structure of adenine and guanine in RNA and DNA, is ubiquitous in living creatures, − also privileged scaffold for drug discovery. , Structurally modified purine derivatives, especially substitution at C6-position with various atom linkages including C-, − N-, − O-, , P-, and S-, − usually exhibit vast kind of biological activity, for example, purine derivatives with S6-substitutions possess bioactivity in antiviral, − immunosuppression, , anticancer, antimalarial, and enzyme inhibition. , Some representative biologically active thiopurines and thiopurine nucleosides are shown in Figure : 6-methylmercaptopurine riboside is very effective to canine distemper and Zika viruses; , very recently in 2022, Cloturin has been approved to have activity against SARS-CoV-2; NMSP provided effective inhibition on HepG2 cancer cells; NBTI is a potent inhibitor for protein ENT1; benzoyl mercaptopurine was identified as a new chemical prototype for CDC7 inhibitor; some 6-substituted thiopurines have been widely used as clinical drugs, such as Azathioprine are used to treat hematological malignancies, rheumatism, solid organ transplantation, and inflammatory bowel disease …”

Synthesis of novel pyrimido[4,5‐b]quinolines as potential anticancer agents and HER2 inhibitors

“…Heterocycle‐based compounds are privileged scaffolds in anticancer drug discovery as they can easily target various metabolic pathways and cellular process in cancer pathology (Amewu et al, 2021; Chaurasiya et al, 2023; Lang et al, 2020). One of the most advantageous heterocycles is pyrimido[4,5‐ b ]quinoline which has been investigated in the recent years as a pharmacophore with versatile pharmacological activities in addition to anticancer activity (Abbas et al, 2011; Alqasoumi et al, 2010; Eghtedari et al, 2022; Ghorab et al, 2009, 2012; El‐Gazzar et al, 2009; Panchabhai et al, 2021).…”

Synthesis of novel pyrimido[4,5‐b]quinoline derivatives as dual EGFR/HER2 inhibitors as anticancer agents

“…Heterocycle-based molecules are favored scaffolds in the development of anticancer drugs, as they can easily target several metabolic pathways and cellular processes in cancer development. [20][21][22] Pyrimidoquinoline, one of the most favorable heterocycles, has recently been studied as a pharmacophore with a variety of pharmacological actions in addition to anticancer activity. [23][24][25][26][27][28][29] The anticancer effectiveness of quinoline moieties has been the subject of numerous investigations.…”