Targeting cancer-associated fibroblasts through inhibition of protein synthesis to abrogate resistance to chemotherapies in pancreatic cancer

Cancer-associated fibroblasts treated with cisplatin facilitates chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathway

“…As a major component of tumor stroma, cancer-associated fibroblasts (CAF) contribute to tumor invasion and metastasis through paracrine factors in different types of cancers such as prostate carcinoma5, breast cancer6 and colorectal cancer7. Multiple research have also indicated that CAF can augment cancer cells’ resistance to chemotherapy agents in breast cancer8, pancreatic cancer9 and head and neck squamous cell carcinoma10. Lung adenocarcinoma is one of the most CAF-rich cancers.…”