Targeting BTK in B Cell Malignancies: From Mode of Action to Resistance Mechanisms
Samir Mouhssine,
Nawar Maher,
Bassam Francis Matti
et al.
Abstract:The B cell receptor (BCR) signaling pathway plays a crucial role in B cell development and contributes to the pathogenesis of B cell neoplasms. In B cell malignancies, the BCR is constitutively active through both ligand-dependent and ligand-independent mechanisms, resulting in continuous Bruton tyrosine kinase (BTK) signaling activation, which provides a survival and proliferation advantage to the neoplastic clone. Among B cell malignancies, those in which the most significant results were obtained by treatme… Show more
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