Targeting Biophysical Cues: a Niche Approach to Study, Diagnose, and Treat Cancer

Zhang, Shirley X.; Liu, Linan; Zhao, Weian

doi:10.1016/j.trecan.2018.02.006

Cited by 22 publications

(16 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[21] Parallel anisotropic orientation of collagen acts as contact guidance for tumor cells, and together with linearization facilitates their migration, tissue invasion, and colonization. [28,29] Unfortunately, the resulting TME microarchitecture with parallel anisotropic alignment, linearization, and crosslinked matrix restricts the access for immune cells and drugs into the tumor, rendering treatment complicated (see Figure 1A). [11,29] In many cases, tumor rejection starts with the infiltration of the tumor cells by immune cells including T cells after the initial cytotoxic T lymphocyte (CTL) response.…”

Section: Ecm Microarchitecture and Stiffness Influence Tumor Infiltra...mentioning

confidence: 99%

“…[28,29] Unfortunately, the resulting TME microarchitecture with parallel anisotropic alignment, linearization, and crosslinked matrix restricts the access for immune cells and drugs into the tumor, rendering treatment complicated (see Figure 1A). [11,29] In many cases, tumor rejection starts with the infiltration of the tumor cells by immune cells including T cells after the initial cytotoxic T lymphocyte (CTL) response. T cells are more successful at infiltrating the restrictive ECM and bypassing obstacles in the ECM than other immune cells.…”

Section: Ecm Microarchitecture and Stiffness Influence Tumor Infiltra...mentioning

confidence: 99%

“…[7][8][9] Solid tumors constitute the majority of all cancers and cancer deaths, and in this respect, because of the vast diversity, are cumbersome to tackle and necessitate research across disciplines. [10] One of the important discoveries in tumor research is that the physical properties of TME play a decisive role in tumor development, antitumor immunity, and response to antitumor therapy in solid Abbreviations: CAF, cancer-associated fibroblast; CTL, cytotoxic T lymphocyte; HIF-1α, hypoxia-inducible factor 1 alpha; IL-10, interleukin 10; PD-1, programmed cell death protein 1; ROS, reactive oxygen species; TAZ, transcriptional coactivator with PDZ-binding motif; TGF-β, tumor growth factor-beta; Treg, regulatory T cell; VEGF, vascular endothelial growth factor; YAP, Yes-associated protein (Nia et al, [12] Lim et al, [18] Zhang et al [29 ]).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The solid tumor microenvironment—Breaking the barrier for T cells

Simsek

Klotzsch

2022

BioEssays

View full text Add to dashboard Cite

The tumor microenvironment (TME) plays a pivotal role in the behavior and development of solid tumors as well as shaping the immune response against them. As the tumor cells proliferate, the space they occupy and their physical interactions with the surrounding tissue increases. The growing tumor tissue becomes a complex dynamic structure, containing connective tissue, vascular structures, and extracellular matrix (ECM) that facilitates stimulation, oxygenation, and nutrition, necessary for its fast growth. Mechanical cues such as stiffness, solid stress, interstitial fluid pressure (IFP), matrix density, and microarchitecture influence cellular functions and ultimately tumor progression and metastasis. In this fight, our body is equipped with T cells as its spearhead against tumors. However, the altered biochemical and mechanical environment of the tumor niche affects T cell efficacy and leads to their exhaustion. Understanding the mechanobiological properties of the TME and their effects on T cells is key for developing novel adoptive tumor immunotherapies.

show abstract

Section: Ecm Microarchitecture and Stiffness Influence Tumor Infiltra...mentioning

confidence: 99%

Section: Ecm Microarchitecture and Stiffness Influence Tumor Infiltra...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The solid tumor microenvironment—Breaking the barrier for T cells

Simsek

Klotzsch

2022

BioEssays

View full text Add to dashboard Cite

show abstract

“…[28][29] Unfortunately, the resulting TME microarchitecture with parallel anisotropic alignment, linearization, and crosslinked matrix restricts the access for immune cells and drugs into the tumor, rendering treatment complicated (see Figure 1A). [11,29] In many cases, tumor rejection starts with the infiltration of the tumor cells by immune cells including T cells after the initial cytotoxic T lymphocyte (CTL) response. T cells are more successful at infiltrating the restrictive ECM and bypassing obstacles in the ECM than other immune cells.…”

Section: Ecm Microarchitecture and Stiffness Influence Tumor Infiltrationmentioning

confidence: 99%

The Solid Tumor Microenvironment - Breaking The Barrier For T Cells<strong> </strong>

Simsek¹,

Klotzsch²

2021

Preprint

View full text Add to dashboard Cite

The tumor microenvironment plays a pivotal role in the behavior and development of solid tumors as well as shaping the immune response against them. As the tumor cells proliferate, the space they occupy and their physical interactions with the surrounding tissue increases. The growing tumor tissue becomes a complex dynamic structure, containing connective tissue, vascular structures, and extracellular matrix that facilitates stimulation, oxygenation, and nutrition, necessary for its fast growth. Mechanical cues such as stiffness, solid stress, interstitial fluid pressure, matrix density, and microarchitecture influence cellular functions and ultimately tumor progression and metastasis. In this fight, our body is equipped with T cells as its spearhead against tumors. However, the altered biochemical and mechanical environment of the tumor niche affects T cell efficacy and leads to their exhaustion. Understanding the mechanobiological properties of the tumor microenvironment and their effects on T cells is key for developing novel adoptive tumor immunotherapies.

show abstract

“…The tissue of breast cancer tumour can be ten times stiffer than the normal breast tissue, and increased breast density is seen in 30% of breast tumors (Lu et al, 2012). The stiffness-sensing capability of cancer and stromal cells influence cell survival and proliferation and provide new insights, so that researchers are able to develop diagnostic methods for cancer formation (Zhang et al, 2018). These diagnostic techniques have the advantage of explaining both mechanical and molecular mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Biophysical properties of cells for cancer diagnosis

Yadav

Barton

Nguyen

2019

Journal of Biomechanics

View full text Add to dashboard Cite

Biophysical properties associated with the microenvironment of a tumour has been recognised as an important modulator for cell behaviour and function. Particularly, tissue rigidity is important during tumour carcinogenesis as it affects the tumour's ability to metastasis. Multiple downstream pathways are affected with a difference in rigidity of the extra cellular matrix. The insight into tumour mechanosignalling represents a promising field that may lead to novel approaches for cancer diagnostics. Measurement of rigidity of the extracellular matrix or the tissue is a potential diagnostics approach for cancer detection.Altered extracellular matrix states persist for a long period of time and have lower heterogeneity compared to protein or genetic markers, therefore are more reliable as biomarkers. On the other hand, measurement of different kinase associated proteins or transcripts provide an early insight into potential transition of cells towards metastasis. Co-localization of transcriptional factors like YAP/TAZ provide an insight to determine if the cells is undergoing metastatic changes. This review explains the unique biophysical properties of the tumour microenvironment that present the potential targets for the diagnosis of cancer.

show abstract

Targeting Biophysical Cues: a Niche Approach to Study, Diagnose, and Treat Cancer

Abstract: Probing the biophysical properties of the tumor niche offers a new perspective in cancer mechanobiology, and supports the development of next-generation diagnostics and therapeutics for cancer, in particular for metastasis.

Cited by 22 publications

References 16 publications

The solid tumor microenvironment—Breaking the barrier for T cells

The solid tumor microenvironment—Breaking the barrier for T cells

The Solid Tumor Microenvironment - Breaking The Barrier For T Cells<strong> </strong>

Biophysical properties of cells for cancer diagnosis

Contact Info

Product

Resources

About