Targeting bile salt homeostasis in biliary diseases
David C. Trampert,
Roni F. Kunst,
Stan F.J. van de Graaf
Abstract:Purpose of review
Advances in the understanding of bile salt synthesis, transport and signalling show the potential of modulating bile salt homeostasis as a therapeutic strategy in cholestatic liver diseases. Here, recent developments in (pre)clinical research in this field is summarized and discussed.
Recent findings
Inhibition of the apical sodium-dependent bile salt transporter (ASBT) and Na+-taurocholate cotransporting polypeptide (NTCP) seems effec… Show more
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