Targeting bacterial degradation machinery as an antibacterial strategy
Radoslav Petkov,
Amy H. Camp,
Rivka L. Isaacson
et al.
Abstract:The exploitation of a cell's natural degradation machinery for therapeutic purposes is an exciting research area in its infancy with respect to bacteria. Here, we review current strategies targeting the ClpCP system, which is a proteolytic degradation complex essential in the biology of many bacterial species of scientific interest. Strategies include using natural product antibiotics or acyldepsipeptides to initiate the up- or down-regulation of ClpCP activity. We also examine exciting recent forays into BacP… Show more
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