Targeting autonomic nervous system as a biomarker of well-ageing in the prevention of stroke

Barthélémy, Jean‐Claude; Pichot, Vincent; Hupin, David; Berger, Mathieu; Celle, Sébastien; Mouhli, Lytissia; Bäck, Magnus; Lacour, Jean‐René; Roche, Frédéric

doi:10.3389/fnagi.2022.969352

Cited by 10 publications

(16 citation statements)

References 238 publications

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“…ANS is a component of the peripheral nervous system that regulates the involuntary physiological process of our body, in particular involving blood pressure and heart rate. An ANS dysregulation i.e., increased activity of sympathetic tone and/or less parasympathetic tone at rest reveals a body homeostasis dysfunction and can predict cardiovascular and metabolic illnesses and is directly correlated with mortality in several diseases (81). Also, autonomic dysfunction, i.e., increased activity of sympathetic tone and/or less parasympathetic tone at rest, is associated with physical deconditioning and/or with chronic fatigue (82), since these two entities are very often linked.…”

Section: Measuring Autonomic Dysfunctionmentioning

confidence: 99%

Section: Measuring Objective Fatigability Resistance: How?mentioning

confidence: 99%

“…The main cardiopulmonary parameters recorded are exercise duration (in min), maximal aerobic power (in W), maximal heart rate (in bpm), oxygen uptake (VO 2 , in L/min) at the first ventilatory threshold (VO 2 at VT1) and at maximal exercise (VO 2 peak). Autonomic function is assessed by a resting ECG recording beforehand [with baroreflex sensitivity and heart rate variability (HRV) measurements] ( 81 ) and by heart rate recovery immediately following the CPET ( 88 ).…”

Section: Measuring Objective Fatigability Resistance: How?mentioning

confidence: 99%

“…The increase or decrease in blood pressure and the corresponding lengthening or shortening response of the following R-R interval. The average slope of these regressions is considered as the index of baroreflex sensitivity (in ms/mmHg) ( 18 , 81 ). For instance, Vigo et al ( 89 ) suggested that reduced aerobic fitness, autonomic dysfunction, and feelings of fatigue represented the hallmark of the clinical phenotype of breast cancer survivors.…”

Section: Measuring Objective Fatigability Resistance: How?mentioning

confidence: 99%

“…Also, Bertisch et al ( 90 ) reported that baroreflex sensitivity was ∼20% lower in patients with sleep disorders compared to healthy controls. (ii) HRV indices measured from short (15 min) ( 91 ) or longer ( 24h-ECG holter ) ECG recordings ( 81 ), using HRV analysis software [e.g., ( 92 )]. The main time domain indices are the standard deviation of NN intervals, the root mean square of successive RR interval differences (RMSSD) and percentage of successive RR intervals that differ by more than 50 ms (pNN50) ( Table 1 ).…”

Section: Measuring Objective Fatigability Resistance: How?mentioning

confidence: 99%

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Measuring objective fatigability and autonomic dysfunction in clinical populations: How and why?

Millet

Bertrand

Lapole

et al. 2023

Front. Sports Act. Living

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Fatigue is a major symptom in many diseases, often among the most common and severe ones and may last for an extremely long period. Chronic fatigue impacts quality of life, reduces the capacity to perform activities of daily living, and has socioeconomical consequences such as impairing return to work. Despite the high prevalence and deleterious consequences of fatigue, little is known about its etiology. Numerous causes have been proposed to explain chronic fatigue. They encompass psychosocial and behavioral aspects (e.g., sleep disorders) and biological (e.g., inflammation), hematological (e.g., anemia) as well as physiological origins. Among the potential causes of chronic fatigue is the role of altered acute fatigue resistance, i.e. an increased fatigability for a given exercise, that is related to physical deconditioning. For instance, we and others have recently evidenced that relationships between chronic fatigue and increased objective fatigability, defined as an abnormal deterioration of functional capacity (maximal force or power), provided objective fatigability is appropriately measured. Indeed, in most studies in the field of chronic diseases, objective fatigability is measured during single-joint, isometric exercises. While those studies are valuable from a fundamental science point of view, they do not allow to test the patients in ecological situations when the purpose is to search for a link with chronic fatigue. As a complementary measure to the evaluation of neuromuscular function (i.e., fatigability), studying the dysfunction of the autonomic nervous system (ANS) is also of great interest in the context of fatigue. The challenge of evaluating objective fatigability and ANS dysfunction appropriately (i.e.,. how?) will be discussed in the first part of the present article. New tools recently developed to measure objective fatigability and muscle function will be presented. In the second part of the paper, we will discuss the interest of measuring objective fatigability and ANS (i.e. why?). Despite the beneficial effects of physical activity in attenuating chronic fatigue have been demonstrated, a better evaluation of fatigue etiology will allow to personalize the training intervention. We believe this is key in order to account for the complex, multifactorial nature of chronic fatigue.

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Section: Measuring Autonomic Dysfunctionmentioning

confidence: 99%

Section: Measuring Objective Fatigability Resistance: How?mentioning

confidence: 99%

Section: Measuring Objective Fatigability Resistance: How?mentioning

confidence: 99%

Section: Measuring Objective Fatigability Resistance: How?mentioning

confidence: 99%

Section: Measuring Objective Fatigability Resistance: How?mentioning

confidence: 99%

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Measuring objective fatigability and autonomic dysfunction in clinical populations: How and why?

Millet

Bertrand

Lapole

et al. 2023

Front. Sports Act. Living

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Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies

Giunta,

Xia,

Pelliccioni

et al. 2023

GeroScience

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Inflammaging refers to the age-related low grade, sterile, chronic, systemic, and long-lasting subclinical, proinflammatory status, currently recognized as the main risk factor for development and progression of the most common age-related diseases (ARDs). Extensive investigations were focused on a plethora of proinflammatory stimuli that can fuel inflammaging, underestimating and partly neglecting important endogenous anti-inflammaging mechanisms that could play a crucial role in such age-related proinflammatory state. Studies on autonomic nervous system (ANS) functions during aging highlighted an imbalance toward an overactive sympathetic nervous system (SNS) tone, promoting proinflammatory conditions, and a diminished parasympathetic nervous system (PNS) activity, playing anti-inflammatory effects mediated by the so called cholinergic anti-inflammatory pathway (CAP). At the molecular level, CAP is characterized by signals communicated via the vagus nerve (with the possible involvement of the splenic nerves) through acetylcholine release to downregulate the inflammatory actions of macrophages, key players of inflammaging. Notably, decreased vagal function and increased burden of activated/senescent macrophages (macrophaging) probably precede the development of several age-related risk factors and diseases, while increased vagal function and reduced macrophaging could be associated with relevant reduction of risk profiles. Hypothalamic–pituitary–adrenal axis (HPA axis) is another pathway related to ANS promoting some anti-inflammatory response mainly through increased cortisol levels. In this perspective review, we highlighted that CAP and HPA, representing broadly “anti-inflammaging” mechanisms, have a reduced efficacy and lose effectiveness in aged people, a phenomenon that could contribute to fuel inflammaging. In this framework, strategies aimed to re-balance PNS/SNS activities could be explored to modulate systemic inflammaging especially at an early subclinical stage, thus increasing the chances to reach the extreme limit of human lifespan in healthy status.

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The interactive effects of psychosocial stress and diet composition on health in primates

Shively

Frye

Negrey

et al. 2023

Neuroscience & Biobehavioral Reviews

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Targeting autonomic nervous system as a biomarker of well-ageing in the prevention of stroke

Abstract: Targeting autonomic nervous system as a biomarker of well-ageing in the prevention of stroke.

Cited by 10 publications

References 238 publications

Measuring objective fatigability and autonomic dysfunction in clinical populations: How and why?

Measuring objective fatigability and autonomic dysfunction in clinical populations: How and why?

Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies

The interactive effects of psychosocial stress and diet composition on health in primates

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