Targeting ARG2 as a novel therapeutic approach for cancer

Grzybowski, Marcin; Pęczkowicz-Szyszka, J.; Wolska, P.; Stańczak, Paulina Seweryna; Welzer, M.; Nikolaev, E. N.; Błaszczyk, Roman; Borek, Bartłomiej; Dzięgielewski, M.; Gzik, Anna; Nowicka, Julita; Brzezińska, J.; Jędrzejczak, Karol; Chrzanowski, Julian; Gołębiowski, Adam; Olczak, Jacek; Dzwonek, Karolina; Dobrzański, Paweł

doi:10.1093/annonc/mdz268.100

Cited by 4 publications

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“…Because an increase in C13‐labeled arginine and its downstream metabolites was observed, the authors suggested an increased uptake of arginine and ornithine synthesis by arginase 2 (ARG2) occurred at the S‐G2‐M phase of cell cycle 111 . In keeping with the finding, knockdown of ARG2 in cancer cells causes reduced cell proliferation 111,112 . ARG2 knockdown also reduced the expression of p21 via the decrease in endothelial nitric oxide synthase 113 .…”

Section: Amino Acid Metabolism Purine and Pyrimidine Metabolism And C...mentioning

confidence: 78%

“…111 In keeping with the finding, knockdown of ARG2 in cancer cells causes reduced cell proliferation. 111,112 ARG2 knockdown also reduced the expression of p21 via the decrease in endothelial nitric oxide synthase. 113 In contrast, ASS promoter methylation is an important oncogenic event in myxofibrosarcoma, and ASS deficiency can promote tumor growth, migration and angiogenesis.…”

Section: Amino Acid Metabolismmentioning

confidence: 90%

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Out of the cycle: Impact of cell cycle aberrations on cancer metabolism and metastasis

Cheung

Hui

Wong

et al. 2022

Intl Journal of Cancer

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The use of cell cycle inhibitors has necessitated a better understanding of the cell cycle in tumor biology to optimize the therapeutic approach. Cell cycle aberrations are common in cancers, and it is increasingly acknowledged that these aberrations exert oncogenic effects beyond the cell cycle. Multiple facets such as cancer metabolism, immunity and metastasis are also affected, all of which are beyond the effect of cell proliferation alone. This review comprehensively summarized the important recent findings and advances in these interrelated processes. In cancer metabolism, cell cycle regulators can modulate various pathways in aerobic glycolysis, glucose uptake and gluconeogenesis, mainly through transcriptional regulation and kinase activities. Amino acid metabolism is also regulated through cell cycle progression. On cancer metastasis, metabolic plasticity, immune evasion, tumor microenvironment adaptation and metastatic site colonization are intricately related to the cell cycle, with distinct regulatory mechanisms at each step of invasion and dissemination. Throughout the synthesis of current understanding, knowledge gaps and limitations in the literature are also highlighted, as are new therapeutic approaches such as combinational therapy and challenges in tackling emerging targeted therapy resistance. A greater understanding of how the cell cycle modulates diverse aspects of cancer biology can hopefully shed light on identifying new molecular targets by harnessing the vast potential of the cell cycle.

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