Targeting Apoptosis, Advanced Glycation End Products and Transforming Growth Factor-β1 by Biguanides and Resveratrol to Ameliorate Experimentally-induced Diabetic Nephropathy

Kabel, Ahmed M.

doi:10.24218/jod.2015.1

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…Ciddi et al showed that 10 mg/kg/d of oral RSV supplementation for 3 weeks reduced AGE formation in diabetic rats . Kabel et al demonstrated that oral administration of RSV (5 mg/kg/d) alone or in combination with metformin for 8 weeks considerably decreased AGE formation in a rat model of STZ‐induced diabetic nephropathy . Yılmaz et al found a significant reduction in the levels of plasma AGE in MGO‐treated rats received 10 mg/kg of RSV via injection compared to the control group .…”

Section: Resultsmentioning

confidence: 99%

“…33 Kabel et al demonstrated that oral administration of RSV (5 mg/kg/d) alone or in combination with metformin for 8 weeks considerably decreased AGE formation in a rat model of STZ-induced diabetic nephropathy. 35 Yılmaz et al found a significant reduction in the levels of plasma AGE in MGO-treated rats received 10 mg/kg of RSV via injection compared to the control group. 24 The authors also stated that treatment with RSV reduced the productions of protein carbonyl and advanced oxidation protein products.…”

Section: Effect Of Rsv On the Generation Of Agesmentioning

confidence: 97%

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The impact of resveratrol on toxicity and related complications of advanced glycation end products: A systematic review

et al. 2019

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Accumulation of advanced glycation end products (AGEs) promotes the generation of free radicals, which leads to chronic oxidative stress predisposing to chronic oxidative stress, inflammation, and related diseases. This systematic review aimed to determine the effect of resveratrol (RSV) on AGE‐induced toxicity and its deleterious consequences. A comprehensive search was performed through literature were published until December 2018 using relevant keywords. The databases that were used for the search were PubMed, Scopus, Embase, ProQuest, and Google Scholar. A total of 29 eligible studies were found and included in the review for the analysis. Except one, all studies showed suppressing effects for RSV on the production of AGEs or receptor for advanced glycation end products (RAGE) and its detrimental consequences including oxidative stress, inflammatory response, cellular immune reactions, insulin response, and atherosclerosis. RSV exerts its effects through influencing RAGE, nuclear factor kappa B (NF‐κB), peroxisome proliferator‐activated receptor (PPAR) γ, and transforming growth factor (TGF)‐β activities. This review suggests that RSV has got potential to decrease AGEs toxicity and inhibit the AGE‐induced complications. More clinical trials are suggested to evaluate the beneficial effect of RSV on AGEs in chronic metabolic diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Effect Of Rsv On the Generation Of Agesmentioning

confidence: 97%

The impact of resveratrol on toxicity and related complications of advanced glycation end products: A systematic review

et al. 2019

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“…erefore, targeting myocardial apoptosis may be an effective target for patients with diabetic cardiomyopathy. H9c2 cardiomyocytes are a cell line derived from an embryonic rat heart whose biological functions are similar to those of primary cardiomyocytes [28]. Nevertheless, it is unclear whether RES can protect the H9c2 cells from HG-stimulated damage.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Inhibits High Glucose-Induced H9c2 Cardiomyocyte Hypertrophy and Damage via RAGE-Dependent Inhibition of the NF-κB and TGF-β1/Smad3 Pathways

Zhu

Yang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Hyperglycaemia is associated with the development of cardiac vascular disease. Resveratrol (RES) is a naturally occurring polyphenolic compound that possesses many biological properties, including anti-inflammatory properties and antioxidation functions. Our study aimed to explore the RES’s protective roles on high glucose (HG)-induced H9c2 cells and the underlying mechanisms. Small-molecule inhibitors, western blotting (WB), as well as reverse-transcription PCR (RT-PCR) were employed to investigate the mechanisms underlying HG-induced damage in H9c2 cells. RES (40 μg/mL) treatment significantly alleviated HG-induced cardiac hypertrophy and cardiac dysfunction. RES abated the HG‐induced increase in the levels of extracellular matrix (ECM) components and inflammatory cytokines, reducing ECM accumulation and inflammatory responses. Additionally, RES administration prevented HG‐induced mitochondrion‐mediated cardiac apoptosis of myocardial cells. In terms of mechanisms, we demonstrated that RES ameliorated the HG‐induced overexpression of receptor for advanced glycation endproducts (RAGE) and downregulation of NF-κB signalling. Moreover, RES inhibited HG‐induced cardiac fibrosis by inhibiting transforming growth factor beta 1 (TGF‐β1)/Smad3‐mediated ECM synthesis in cultured H9c2 cardiomyocytes. Further studies revealed that the effects of RES against HG‐induced upregulation of NF-κB and TGF‐β1/Smad3 pathways were similar to those of FPS-ZM1, a RAGE inhibitor. Collectively, the results implied that RES might help alleviate HG‐induced cardiotoxicity via RAGE‐dependent downregulation of the NF-κB and TGF‐β/Smad3 pathways. This study provided evidence that RES can be developed as a promising cardioprotective drug.

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Quantitative modeling for prediction of thermodynamic properties of some pyridine derivatives using molecular descriptors and genetic algorithm‐multiple linear regressions

Hajibabaei

Shafiei

Abdoli‐Senejani

2019

J Chinese Chemical Soc

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Pyridines are compounds with a wide range of biological activities and they are the basis of several groups of drugs. In this study, the relationship between molecular descriptors and the thermal energy (E th kJ/mol), heat capacity (C v J/molK), entropy (S J/mol K), enthalpy of formation (ΔH f kJ/mol), and Gibbs free energy (ΔG kJ/mol) of pyridine derivatives is studied. These properties were calculated at the Hartree-Fock level of theory and 6-311G* G basis sets by Gaussian 09 software. The chemical structures of 171 pyridine derivatives were drawn by the Gauss View 05 program.The genetic algorithm-multiple linear regression (GA-MLR) and backward methods-were used to select the suitable descriptors and also for predicting the thermodynamic properties of pyridine derivatives. The correlations between the molecular descriptors in the best models were discussed by the Pearson coefficient correlation and collinearity statistics. The predictive powers of the GA-MLR models are studied using leave-one-out (LOO) cross-validation and external test set. The best quantitative structure-property relationship (QSPR) models are obtained based on the statistical parameters, such as R 2 , Q 2 LOO, and RMSE values for the data sets. The predictive ability of the GA-MLR models with two-three selected molecular descriptors was found to be satisfactory and could be used for modeling and predicting of the mentioned properties of nontested pyridine derivatives. K E Y W O R D S QSPR, pyridine derivatives, leave-one-out cross-validation, genetic algorithm-multiple linear regression

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Targeting Apoptosis, Advanced Glycation End Products and Transforming Growth Factor-β1 by Biguanides and Resveratrol to Ameliorate Experimentally-induced Diabetic Nephropathy

Cited by 5 publications

References 30 publications

The impact of resveratrol on toxicity and related complications of advanced glycation end products: A systematic review

The impact of resveratrol on toxicity and related complications of advanced glycation end products: A systematic review

Resveratrol Inhibits High Glucose-Induced H9c2 Cardiomyocyte Hypertrophy and Damage via RAGE-Dependent Inhibition of the NF-κB and TGF-β1/Smad3 Pathways

Quantitative modeling for prediction of thermodynamic properties of some pyridine derivatives using molecular descriptors and genetic algorithm‐multiple linear regressions

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