Targeting anoikis resistance as a strategy for cancer therapy

Wang, Yumin; Cheng, Sihang; Fleishman, Joshua S.; Chen, Jichao; Tang, Hailin; Chen, Zhe-Sheng; Chen, Wenkuan; Ding, Mingchao

doi:10.1016/j.drup.2024.101099

Drug Resistance Updates

2024

DOI: 10.1016/j.drup.2024.101099

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Targeting anoikis resistance as a strategy for cancer therapy

Yumin Wang,

Sihang Cheng,

Joshua S. Fleishman

et al.

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2024

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Cited by 2 publications

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Anoikis in cell fate, physiopathology, and therapeutic interventions

Mei,

Jiang,

Tian

et al. 2024

MedComm

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The extracellular matrix (ECM) governs a wide spectrum of cellular fate processes, with a particular emphasis on anoikis, an integrin‐dependent form of cell death. Currently, anoikis is defined as an intrinsic apoptosis. In contrast to traditional apoptosis and necroptosis, integrin correlates ECM signaling with intracellular signaling cascades, describing the full process of anoikis. However, anoikis is frequently overlooked in physiological and pathological processes as well as traditional in vitro research models. In this review, we summarized the role of anoikis in physiological and pathological processes, spanning embryonic development, organ development, tissue repair, inflammatory responses, cardiovascular diseases, tumor metastasis, and so on. Similarly, in the realm of stem cell research focused on the functional evolution of cells, anoikis offers a potential solution to various challenges, including in vitro cell culture models, stem cell therapy, cell transplantation, and engineering applications, which are largely based on the regulation of cell fate by anoikis. More importantly, the regulatory mechanisms of anoikis based on molecular processes and ECM signaling will provide new strategies for therapeutic interventions (drug therapy and cell‐based therapy) in disease. In summary, this review provides a systematic elaboration of anoikis, thus shedding light on its future research.

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Anoikis in cell fate, physiopathology, and therapeutic interventions

Mei,

Jiang,

Tian

et al. 2024

MedComm

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Implication of Capillary Morphogenesis Gene 2 (CMG2) in the Disease Progression and Peritoneal Metastasis of Pancreatic Cancer

Fang,

Bunston,

et al. 2024

Cancers

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Capillary morphogenesis gene 2 (CMG2) mediates cell–matrix interactions to facilitate cell adhesion and migration. CMG2 has been implicated in the disease progression of breast cancer, prostate cancer and gastric cancer. The present study aims to determine the role of CMG2 in the disease progression and peritoneal metastasis of pancreatic cancer. Pancreatic tumour samples were collected from Peking University Cancer Hospital. CMG2 expression was determined using quantitative PCR. After the creation of knockdown and overexpression of CMG2 in pancreatic cancer cells, the effect of CMG2 on several cell functions and adhesion to the peritoneum was examined. Potential pathways regulated by CMG2 were found via proteomics analysis and drug tests. CMG2 was upregulated in pancreatic cancer tissues and associated with a poor prognosis. CMG2 was increased in metastatic lesions and those primary tumours with distant metastases. CMG2 promotes cell–cell, cell–matrix and cell–hyaluronic acid adhesion, which may be mediated by epidermal growth factor receptor (EGFR) and focal adhesion kinase (FAK) pathway activation.

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Targeting anoikis resistance as a strategy for cancer therapy

Cited by 2 publications

References 353 publications

Anoikis in cell fate, physiopathology, and therapeutic interventions

Anoikis in cell fate, physiopathology, and therapeutic interventions

Implication of Capillary Morphogenesis Gene 2 (CMG2) in the Disease Progression and Peritoneal Metastasis of Pancreatic Cancer

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